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Respiratory Tract Infections Drug Development Pipeline Review, 2018

Published By :

GBI Research

Published Date : Jul 2018

Category :

Pharmaceutical

No. of Pages : 153 Pages

Respiratory Tract Infections Drug Development Pipeline Review, 2018

Summary

This report provides an overview of the pipeline landscape for respiratory tract infections. It provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for tuberculosis, diphtheria and pertussis (whooping cough), and features dormant and discontinued products.

Tuberculosis, commonly known as TB, is a bacterial infection that can spread through the lymph nodes and bloodstream to any organ in the body. It is most often found in the lungs. The symptoms of tuberculosis range from no symptoms (latent tuberculosis) to symptoms of active disease. Symptoms include overall sensation of feeling unwell; cough, possibly with bloody mucus, fatigue, shortness of breath, weight loss and pain in the chest. There are 206 products in development for this indication.

Diphtheria is a bacterial infection that affects the membranes of the throat and nose. If left untreated, diphtheria can cause severe damage to kidneys, nervous system, and heart. Symptoms include sore throat and hoarseness, swollen glands (enlarged lymph nodes) in neck, nasal discharge, fever and chills and malaise. Treatment includes antitoxins and antibiotics. There are 31 products in development for this indication.

Pertussis is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis. Symptoms include runny nose, nasal congestion, sneezing, red, watery eyes and dry cough. Treatment includes antibiotics. There are 40 products in development for this indication.

Molecular targets acted on by products in development for respiratory tract infections include bacterial proteins and toxins. Companies operating in this pipeline space include Beijing Minhai Biotechnology, Sanofi and GlaxoSmithKline.

Scope

- Which companies are the most active within each pipeline?
- Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
- To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
- What are the most important R&D milestones and data publications to have happened in this disease area?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication and a comprehensive picture of recent updates and milestones for each
- Analyze the companies, institutions and universities currently operating in the pipeline and the products being fielded by each of these
- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration

1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 5
1.2 List of Figures 7
2 Introduction 8
2.1 Respiratory Tract Infections Report Coverage 8
2.2 Tuberculosis - Overview 8
2.3 Diphtheria - Overview 8
2.4 Pertussis (Whooping Cough) - Overview 8
3 Therapeutics Development 9
3.1 Tuberculosis 9
3.2 Diphtheria 25
3.3 Pertussis (Whooping Cough) 32
4 Therapeutics Assessment 40
4.1 Tuberculosis 40
4.2 Diphtheria 49
4.3 Pertussis (Whooping Cough) 53
5 Companies Involved in Therapeutics Development 58
5.1 Tuberculosis 58
5.2 Diphtheria 86
5.3 Pertussis (Whooping Cough) 94
6 Dormant Projects 105
6.1 Tuberculosis 105
6.2 Diphtheria 112
6.3 Pertussis (Whooping Cough) 114
7 Discontinued Products 117
7.1 Tuberculosis 117
7.2 Diphtheria 117
7.3 Pertussis (Whooping Cough) 117
8 Product Development Milestones 118
8.1 Tuberculosis 118
8.2 Diphtheria 129
8.3 Pertussis (Whooping Cough) 138
9 Appendix 152
9.1 Methodology 152
9.2 Coverage 152
9.3 Secondary Research 152
9.4 Primary Research 152
9.5 Expert Panel Validation 152
9.6 Contact Us 153
9.7 Disclaimer 153

1.1 List of Tables
Table 1: Number of Products under Development for Tuberculosis 9
Table 2: Number of Products under Development by Companies Tuberculosis 11
Table 3: Number of Products under Development by Universities/Institutes Tuberculosis 14
Table 4: Products under Development by Companies Tuberculosis 16
Table 5: Products under Development by Universities/Institutes Tuberculosis 21
Table 6: Number of Products under Development for Diphtheria 25
Table 7: Number of Products under Development by Companies Diphtheria 27
Table 8: Number of Products under Development by Universities/Institutes Diphtheria 28
Table 9: Products under Development by Companies Diphtheria 29
Table 10: Products under Development by Universities/Institutes Diphtheria 31
Table 11: Number of Products under Development for Pertussis (Whooping Cough) 32
Table 12: Number of Products under Development by Companies Pertussis (Whooping Cough) 34
Table 13: Number of Products under Development by Universities/Institutes Pertussis (Whooping Cough) 35
Table 14: Products under Development by Companies Pertussis (Whooping Cough) 36
Table 15: Products under Development by Universities/Institutes Pertussis (Whooping Cough) 39
Table 16: Number of Products by Stage and Target Tuberculosis 41
Table 17: Number of Products by Stage and Mechanism of Action Tuberculosis 44
Table 18: Number of Products by Stage and Route of Administration Tuberculosis 47
Table 19: Number of Products by Stage and Molecule Type Tuberculosis 48
Table 20: Number of Products by Stage and Target Diphtheria 50
Table 21: Number of Products by Stage and Route of Administration Diphtheria 51
Table 22: Number of Products by Stage and Molecule Type Diphtheria 53
Table 23: Number of Products by Stage and Target Pertussis (Whooping Cough) 54
Table 24: Number of Products by Stage and Mechanism of Action Pertussis (Whooping Cough) 54
Table 25: Number of Products by Stage and Route of Administration Pertussis (Whooping Cough) 56
Table 26: Number of Products by Stage and Molecule Type Pertussis (Whooping Cough) 57
Table 27: Tuberculosis - Pipeline by Abera Bioscience AB 58
Table 28: Tuberculosis - Pipeline by AGILeBiotics BV 58
Table 29: Tuberculosis - Pipeline by Akshaya Bio Inc 59
Table 30: Tuberculosis - Pipeline by Archivel Farma SL 59
Table 31: Tuberculosis - Pipeline by AstraZeneca Plc 60
Table 32: Tuberculosis - Pipeline by Aucta Pharmaceuticals LLC 60
Table 33: Tuberculosis - Pipeline by BioLingus AG 61
Table 34: Tuberculosis - Pipeline by Bioversys AG 61
Table 35: Tuberculosis - Pipeline by Celgene Corp 62
Table 36: Tuberculosis - Pipeline by Chongqing Zhifei Biological Products Co Ltd 62
Table 37: Tuberculosis - Pipeline by Consegna Pharma Inc 63
Table 38: Tuberculosis - Pipeline by Crestone Inc 63
Table 39: Tuberculosis - Pipeline by Daiichi Sankyo Co Ltd 64
Table 40: Tuberculosis - Pipeline by Demuris Ltd 64
Table 41: Tuberculosis - Pipeline by Eisai Co Ltd 65
Table 42: Tuberculosis - Pipeline by Eli Lilly and Co 65
Table 43: Tuberculosis - Pipeline by EpiVax Inc 66
Table 44: Tuberculosis - Pipeline by Evotec AG 66
Table 45: Tuberculosis - Pipeline by FIT Biotech Oy 67
Table 46: Tuberculosis - Pipeline by GangaGen Inc 67
Table 47: Tuberculosis - Pipeline by GC Pharma 68
Table 48: Tuberculosis - Pipeline by GlaxoSmithKline Plc 68
Table 49: Tuberculosis - Pipeline by Globeimmune Inc 69
Table 50: Tuberculosis - Pipeline by Hager Biosciences LLC 69
Table 51: Tuberculosis - Pipeline by Hsiri Therapeutics LLC 70
Table 52: Tuberculosis - Pipeline by Immodulon Therapeutics Ltd 70
Table 53: Tuberculosis - Pipeline by Immunitor Inc 71

1.2 List of Figures
Figure 1: Number of Products under Development for Tuberculosis 9
Figure 2: Number of Products under Development by Companies Tuberculosis 10
Figure 3: Number of Products under Development by Universities/Institutes Tuberculosis 13
Figure 4: Number of Products under Development for Diphtheria 25
Figure 5: Number of Products under Development by Companies Diphtheria 26
Figure 6: Number of Products under Development by Universities/Institutes Diphtheria 28
Figure 7: Number of Products under Development for Pertussis (Whooping Cough) 32
Figure 8: Number of Products under Development by Companies Pertussis (Whooping Cough) 33
Figure 9: Number of Products under Development by Universities/Institutes Pertussis (Whooping Cough) 35
Figure 10: Number of Products by Top 10 Targets Tuberculosis 40
Figure 11: Number of Products by Stage and Top 10 Targets Tuberculosis 40
Figure 12: Number of Products by Top 10 Mechanism of Actions Tuberculosis 43
Figure 13: Number of Products by Stage and Top 10 Mechanism of Actions Tuberculosis 43
Figure 14: Number of Products by Routes of Administration Tuberculosis 46
Figure 15: Number of Products by Stage and Routes of Administration Tuberculosis 46
Figure 16: Number of Products by Top 10 Molecule Types Tuberculosis 47
Figure 17: Number of Products by Stage and Top 10 Molecule Types Tuberculosis 48
Figure 18: Number of Products by Targets Diphtheria 49
Figure 19: Number of Products by Stage and Targets Diphtheria 49
Figure 20: Number of Products by Routes of Administration Diphtheria 50
Figure 21: Number of Products by Stage and Routes of Administration Diphtheria 51
Figure 22: Number of Products by Molecule Types Diphtheria 52
Figure 23: Number of Products by Stage and Molecule Types Diphtheria 52
Figure 24: Number of Products by Targets Pertussis (Whooping Cough) 53
Figure 25: Number of Products by Stage and Targets Pertussis (Whooping Cough) 54
Figure 26: Number of Products by Routes of Administration Pertussis (Whooping Cough) 55
Figure 27: Number of Products by Stage and Routes of Administration Pertussis (Whooping Cough) 55
Figure 28: Number of Products by Top 10 Molecule Types Pertussis (Whooping Cough) 56
Figure 29: Number of Products by Stage and Molecule Types Pertussis (Whooping Cough) 57

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