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Global Bone Graft Substitutes Market Analysis and Forecast 2022-2030

Report ID:576Healthcare245 pages

Bone Graft Substitutes Market Statistics

The global bone graft substitute market is likely to exhibit a growth rate of 6.3% from 2022 to 2030. The market is expected to observe an estimated value of USD 4.94 billion by 2030 as against its previous valuation of USD 3.06 billion in 2022.

The increasing trend of various bone diseases such as osteoporosis, arthritis, and other joint disorder are anticipated to drive the global bone graft substitute market in the coming years.

Increasing Cases of Osteonecrosis to Strengthen Bone Graft Substitutes Market

Osteonecrosis is a rare disease where the bone death of a particular area happens due to lack of blood supply. It is also known as Avascular Necrosis alternatively, leading to damage of femoral head and eventual collapse of the bone. This often goes unnoticed in the initial stage unless the patient gets totally crippled. However, if the diagnosis happens on the right time, the core depression with bone grafting is considered as the first stage in the line of treatments.

So far osteonecrosis affected a nominal percentage of people, hence it falls under the category of rare diseases. However, since the outbreak of the covid pandemic, the world is witnessing a surge in the number of osteonecrosis patients population. Although, there are several causes for osteonecrosis such as previous history, smoking, alcohol, steroids, and idiopathic. However, most cases that are emerging post-pandemic are due to steroids as line of treatment to combat covid cases. Therefore, there may be significant growth opportunities for the global bone graft substitute market.

Global Bone Graft Substitutes Market Share By Region Type

Better Technologies to Drive the Bone Graft Substitutes Market

The bone grafting either uses patient’s bone from other part of the body as a material or sources through artificial, synthetic substitutes. With the advent of technology in the healthcare, bone grafts substitutes have been classified into materials used in them such as-

Allograft- they are either used as a single material or in combination with other materials.

Cell-based- it involves the use of cells to help generate new tissue and combined as support matrix, such as mesenchymal stem cells.

Ceramic based bone graft substitute involves calcium sulphate, calcium phosphate, and bioglass either used as a single material or in combination, such as OsteoSet, ProOsteon. The shelf life of ceramic bone grafting as far as artificial substitutes is concerned.

Polymer graft uses both types of materials, degradable and non-degradable either in individually or in combination.

All these technologies in the orthopedic sector have given an ample choice to the patients, depending on the age and lifestyle of the patient the material will be decided by the surgeon, thus likely to boost the growth of the global bone graft substitutes market.

However, the high cost of surgery and bone grafts substitutes materials is expected to restraint the global bone graft substitute market during the forecast period.

Nevertheless, the growing geriatric population with bone and joint diseases may strengthen the global bone graft substitute market in the coming years.

Data Points Market Insights
Market Value 2022 US$ 3.06 billion
Market Value 2030 US$ 4.94 billion
Market Growth Rate 2020-2026 6.3%
Top Regional Market Asia Pacific
Key Players TBF Tissue Engineering, OST Development, AlloSource,Medtronic Orthofix Holdings, Inc. Wright Medical Group N.V., GeistlichPharma AG, Stryker Corporation, Biobank DePuySynthes, Inc., Baxter, Nuvasive, Inc.
Segment- Material Type Outlook (Allograft, Synthetic)
Application Outlook (Craniomaxillofacial, Dental, LongBone, Spinal Fusion, Foot & Ankle)

Osteoconductivity to Augment Allograft Segment

Based on material type, the global bone graft substitute market allograft, synthetics, composites, polymers, and bone morphogenic proteins. However, the allograft material is likely to dominate the material segment. The growth can be credited to osteoconductivity features of the allograft as it helps in clinical success by further helping in stable bone-implant formation. Furthermore, the allografts would not need any bones for surgery, this ensures faster healing, pushing the global bone graft substitutes market to expand in the years to come.

The synthetic segment will continue to grow over the forecast period due to lesser risk of infection and disease transmission, further the synthetic segment is divided into – ceramics, polymers, Bone Morphogenic Proteins (BMP). However, the ceramic material is expected to drive the bone graft substitutes market in the coming years.

In terms of applications, the global bone graft substitute market is segmented into- joint reconstruction, foot and ankle, spinal fusion, long bone, dental, and craniomaxillofacial. However, the dental graft segment is anticipated to bring forth lucrative growth opportunities for the bone graft substitutes market. Availability of advanced techniques is leading to the growing adoption of dental implants procedures, thus may boost the growth opportunities for dental bone grafts during the forecast period.

On the other hand, joint reconstruction segment is anticipated to grow moderately due to rising number of joint replacement surgeries such as shoulder replacement, hip replacement, and knee replacement. The growth of this segment can be attributed to rising cases of arthritis, avascular necrosis, and increasing geriatric population with bone degeneration.

The global bone graft market is further segmented into hospitals and speciality clinics, on the basis of end-users. But the hospital segment is expected to register the highest CAGR during the forecast period. The growth of this segment is attributable to the availability of all the facilities such as skilled orthopaedists, surgery needs, beds, etc under one roof for arthroplasty procedures and replacement surgeries.

Regional Outlook

In terms of regional growth, Asia Pacific is anticipated to hold a lion’s share in the global bone graft substitute market, owing to growing medical tourism, increasing patient pool, availability of skilled surgeons and rising adoption of advanced bone grafts.

Simultaneously, North America is expected to witness a huge growth during the forecast period, the growth in this region can be credited to increasing geriatric population, rising adoption of advanced bone grafts substitutes, further the availability of robotic surgeries, and presence of prominent market players etc.

Europe is emerging as a lucrative market due to the growing adoption of advanced bone graft substitutes, the rising prevalence of joint and bone surgeries.

Competitive Landscape

In Feb 2022, MTF Biologics awarded more than nine researchers with a grant of USD 1 million to accelerate innovation in tissue transplants and support allograft research.

In Feb 2022, Orthofix, a global leader in orthopaedics and spine devices announced the launch of Opus™ BA, a synthetic bioactive bone graft for the treatment of lumbar spine and cervical fusion procedures.

In April 2022, NuVasive, a global provider of minimally invasive procedures in spine solutions announced the NuVasive Simplify® Cervical Disc (Simplify Disc) two-level investigation device exemption approved by Food and Drug Administration published in the Journal of Neurosurgery: Spine

In March 2022, Medtronic Plc, a world leader in healthcare technology introduced its first patient implantable TITAN 2, a pivotal study to study and evaluate the efficacy of the implantable device in tibial neuromodulation for bladder incontinence.

Following are some of the prominent players in the global bone graft substitutes market-

  • Wright Medical Group N.V.
  • GeistlichPharma AG
  • Stryker Corporation
  • Biobank
  • DePuySynthes, Inc.
  • Baxter
  • Nuvasive, Inc.
  • TBF Tissue Engineering
  • OST Devloppement
  • AlloSource
  • Medtronic
  • Orthofix Holdings, Inc.

Material Type Outlook (Revenue, USD Billion)

Allograft

  • Demineralized Bone Matrix
  • Others

Synthetic

  • Ceramics
  • HAP
  • β-TCP
  • α-TCP
  • Bi-phasic Calcium Phosphates (BCP)
  • Others
  • Polymers
  • Bone Morphogenic Proteins (BMP)
  • Composites

Application Outlook (Revenue, USD Billion)

  • Craniomaxillofacial
  • Dental
  • Long Bone
  • Spinal Fusion
  • Foot & Ankle
  • Joint Reconstruction

Regional Outlook

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa (MEA)

Frequently Asked Questions

  • What would be the valuation of the global bone graft substitutes market by the end of forecast period?

The estimated market value of the bone graft substitute is expected to reach USD 4.94 billion by 2030

  • Which end-user segment will dominate during the forecast period?

The forecast period of the global bone graft substitute market would be from 2022 to 2030

  • What are the factors that will drive the global bone graft substitute market?

Prevalence of diseases such as arthritis, osteoporosis, and other bone degeneration are expected to be the major drivers in the global bone graft market.

  • How would be the market growth of bone graft substitute market over the forecast years?

The global bone graft market is expected to register growth of CAGR 6.3% over the forecast period.

Table Of Content

1. Executive Summary
1.1. Global Market Outlook
1.2. Demand-side Trends
1.3. Supply-side Trends
1.4. Technology Roadmap Analysis
1.5. Analysis and Recommendations

2. Market Overview
2.1. Market Coverage / Taxonomy
2.2. Market Definition / Scope / Limitations

3. Market Background
3.1. Market Dynamics
3.1.1. Drivers
3.1.2. Restraints
3.1.3. Opportunity
3.1.4. Trends
3.2. Scenario Forecast
3.2.1. Demand in Optimistic Scenario
3.2.2. Demand in Likely Scenario
3.2.3. Demand in Conservative Scenario
3.3. Opportunity Map Analysis
3.4. Product Life Cycle Analysis
3.5. Supply Chain Analysis
3.6. Investment Feasibility Matrix
3.7. Value Chain Analysis
3.8. PESTLE and Porter’s Analysis
3.9. Regulatory Landscape
3.9.1. By Key Regions
3.9.2. By Key Countries
3.10. Regional Parent Market Outlook
3.11. Production and Consumption Statistics
3.12. Import and Export Statistics

4. Global Bone Graft Substitutes Market Analysis 2017-2021 and Forecast, 2022-2032
4.1. Historical Market Size Value (US$ Mn) & Volume (Units) Analysis, 2017-2021
4.2. Current and Future Market Size Value (US$ Mn) & Volume (Units) Projections, 2022-2032
4.2.1. Y-o-Y Growth Trend Analysis
4.2.2. Absolute $ Opportunity Analysis

5. Global Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Material Type Outlook
5.1. Introduction / Key Findings
5.2. Historical Market Size Value (US$ Mn) & Volume (Units) Analysis By Material Type Outlook, 2017-2021
5.3. Current and Future Market Size Value (US$ Mn) & Volume (Units) Analysis and Forecast By Material Type Outlook, 2022-2032
5.3.1. Allograft
5.3.1.1. Demineralized Bone Matrix
5.3.1.2. Others
5.3.2. Synthetic
5.3.2.1. Ceramics
5.3.2.3. HAP
5.3.2.3. β-TCP
5.3.2.4. α-TCP
5.3.2.5. Bi-phasic Calcium Phosphates (BCP)
5.3.2.6. Others
5.3.2.7. Polymers
5.3.2.8. Bone Morphogenic Proteins (BMP)
5.3.2.9. Composites
5.4. Y-o-Y Growth Trend Analysis By Material Type Outlook, 2017-2021
5.5. Absolute $ Opportunity Analysis By Material Type Outlook, 2022-2032

6. Global Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Application Outlook
6.1. Introduction / Key Findings
6.2. Historical Market Size Value (US$ Mn) & Volume (Units) Analysis By Application Outlook, 2017-2021
6.3. Current and Future Market Size Value (US$ Mn) & Volume (Units) Analysis and Forecast By Application Outlook, 2022-2032
6.3.1. Craniomaxillofacial
6.3.2. Dental
6.3.3. Long Bone
6.3.4. Spinal Fusion
6.3.5. Foot & Ankle
6.3.6. Joint Reconstruction
6.4. Y-o-Y Growth Trend Analysis By Application Outlook, 2017-2021
6.5. Absolute $ Opportunity Analysis By Application Outlook, 2022-2032

7. Global Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Region
7.1. Introduction
7.2. Historical Market Size Value (US$ Mn) & Volume (Units) Analysis By Region, 2017-2021
7.3. Current Market Size Value (US$ Mn) & Volume (Units) Analysis and Forecast By Region, 2022-2032
7.3.1. North America
7.3.2. Latin America
7.3.3. Europe
7.3.4. East Asia
7.3.5. South Asia
7.3.6. Oceania
7.3.7. MEA
7.4. Market Attractiveness Analysis By Region

8. North America Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Country
8.1. Historical Market Size Value (US$ Mn) & Volume (Units) Trend Analysis By Market Taxonomy, 2017-2021
8.2. Market Size Value (US$ Mn) & Volume (Units) Forecast By Market Taxonomy, 2022-2032
8.2.1. By Country
8.2.1.1. U.S.
8.2.1.2. Canada
8.2.2. By Material Type Outlook
8.2.3. By Application Outlook
8.3. Market Attractiveness Analysis
8.3.1. By Country
8.3.2. By Material Type Outlook
8.3.3. By Application Outlook
8.4. Key Takeaways

9. Latin America Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Country
9.1. Historical Market Size Value (US$ Mn) & Volume (Units) Trend Analysis By Market Taxonomy, 2017-2021
9.2. Market Size Value (US$ Mn) & Volume (Units) Forecast By Market Taxonomy, 2022-2032
9.2.1. By Country
9.2.1.1. Brazil
9.2.1.2. Mexico
9.2.1.3. Argentina
9.2.1.4. Chile
9.2.1.5. Peru
9.2.1.6. Rest of Latin America
9.2.2. By Material Type Outlook
9.2.3. By Application Outlook
9.3. Market Attractiveness Analysis
9.3.1. By Country
9.3.2. By Material Type Outlook
9.3.3. By Application Outlook
9.4. Key Takeaways

10. Europe Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Country
10.1. Historical Market Size Value (US$ Mn) & Volume (Units) Trend Analysis By Market Taxonomy, 2017-2021
10.2. Market Size Value (US$ Mn) & Volume (Units) Forecast By Market Taxonomy, 2022-2032
10.2.1. By Country
10.2.1.1. Germany
10.2.1.2. Italy
10.2.1.3. France
10.2.1.4. U.K.
10.2.1.5. Spain
10.2.1.6. Russia
10.2.1.7. BENELUX
10.2.1.8. Rest of Europe
10.2.2. By Material Type Outlook
10.2.3. By Application Outlook
10.3. Market Attractiveness Analysis
10.3.1. By Country
10.3.2. By Material Type Outlook
10.3.3. By Application Outlook
10.4. Key Takeaways

11. East Asia Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Country
11.1. Historical Market Size Value (US$ Mn) & Volume (Units) Trend Analysis By Market Taxonomy, 2017-2021
11.2. Market Size Value (US$ Mn) & Volume (Units) Forecast By Market Taxonomy, 2022-2032
11.2.1. By Country
11.2.1.1. China
11.2.1.2. Japan
11.2.1.3. South Korea
11.2.2. By Material Type Outlook
11.2.3. By Application Outlook
11.3. Market Attractiveness Analysis
11.3.1. By Country
11.3.2. By Material Type Outlook
11.3.3. By Application Outlook
11.4. Key Takeaways

12. South Asia Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Country
12.1. Historical Market Size Value (US$ Mn) & Volume (Units) Trend Analysis By Market Taxonomy, 2017-2021
12.2. Market Size Value (US$ Mn) & Volume (Units) Forecast By Market Taxonomy, 2022-2032
12.2.1. By Country
12.2.1.1. India
12.2.1.2. Thailand
12.2.1.3. Malaysia
12.2.1.4. Indonesia
12.2.1.5. Rest of South Asia
12.2.2. By Material Type Outlook
12.2.3. By Application Outlook
12.3. Market Attractiveness Analysis
12.3.1. By Country
12.3.2. By Material Type Outlook
12.3.3. By Application Outlook
12.4. Key Takeaways

13. Oceania Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Country
13.1. Historical Market Size Value (US$ Mn) & Volume (Units) Trend Analysis By Market Taxonomy, 2017-2021
13.2. Market Size Value (US$ Mn) & Volume (Units) Forecast By Market Taxonomy, 2022-2032
13.2.1. By Country
13.2.1.1. Australia
13.2.1.2. New Zealand
13.2.2. By Material Type Outlook
13.2.3. By Application Outlook
13.3. Market Attractiveness Analysis
13.3.1. By Country
13.3.2. By Material Type Outlook
13.3.3. By Application Outlook
13.4. Key Takeaways

14. MEA Bone Graft Substitutes Market Analysis 2017-2021 and Forecast 2022-2032, By Country
14.1. Historical Market Size Value (US$ Mn) & Volume (Units) Trend Analysis By Market Taxonomy, 2017-2021
14.2. Market Size Value (US$ Mn) & Volume (Units) Forecast By Market Taxonomy, 2022-2032
14.2.1. By Country
14.2.1.1. GCC
14.2.1.2. Rest of MEA
14.2.2. By Material Type Outlook
14.2.3. By Application Outlook
14.3. Market Attractiveness Analysis
14.3.1. By Country
14.3.2. By Material Type Outlook
14.3.3. By Application Outlook
14.4. Key Takeaways

15. Key Countries Bone Graft Substitutes Market Analysis
15.1. U.S.
15.1.1. Pricing Analysis
15.1.2. Market Share Analysis, 2021
15.1.2.1. By Material Type Outlook
15.1.2.2. By Application Outlook
15.2. Canada
15.2.1. Pricing Analysis
15.2.2. Market Share Analysis, 2021
15.2.2.1. By Material Type Outlook
15.2.2.2. By Application Outlook
15.3. Brazil
15.3.1. Pricing Analysis
15.3.2. Market Share Analysis, 2021
15.3.2.1. By Material Type Outlook
15.3.2.2. By Application Outlook
15.4. Mexico
15.4.1. Pricing Analysis
15.4.2. Market Share Analysis, 2021
15.4.2.1. By Material Type Outlook
15.4.2.2. By Application Outlook
15.5. Argentina
15.5.1. Pricing Analysis
15.5.2. Market Share Analysis, 2021
15.5.2.1. By Material Type Outlook
15.5.2.2. By Application Outlook

16. Market Structure Analysis
16.1. Competition Dashboard
16.2. Competition Benchmarking
16.3. Market Share Analysis of Top Players
16.3.1.  By Regional
16.3.2.  By Material Type Outlook
16.3.3.  By Application Outlook

17. Competition Analysis
17.1. Competition Deep Dive
17.1.1. Wright Medical Group N.V.
17.1.1.1. Overview
17.1.1.2. Product Portfolio
17.1.1.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.1.4. Sales Footprint
17.1.1.5. Strategy Overview
17.1.1.5.1. Marketing Strategy
17.1.1.5.2. Product Strategy
17.1.1.5.3. Channel Strategy
17.1.2. GeistlichPharma AG
17.1.2.1. Overview
17.1.2.2. Product Portfolio
17.1.2.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.2.4. Sales Footprint
17.1.2.5. Strategy Overview
17.1.2.5.1. Marketing Strategy
17.1.2.5.2. Product Strategy
17.1.2.5.3. Channel Strategy
17.1.3. Stryker Corporation
17.1.3.1. Overview
17.1.3.2. Product Portfolio
17.1.3.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.3.4. Sales Footprint
17.1.3.5. Strategy Overview
17.1.3.5.1. Marketing Strategy
17.1.3.5.2. Product Strategy
17.1.3.5.3. Channel Strategy
17.1.4. Biobank
17.1.4.1. Overview
17.1.4.2. Product Portfolio
17.1.4.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.4.4. Sales Footprint
17.1.4.5. Strategy Overview
17.1.4.5.1. Marketing Strategy
17.1.4.5.2. Product Strategy
17.1.4.5.3. Channel Strategy
17.1.5. DePuySynthes, Inc.
17.1.5.1. Overview
17.1.5.2. Product Portfolio
17.1.5.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.5.4. Sales Footprint
17.1.5.5. Strategy Overview
17.1.5.5.1. Marketing Strategy
17.1.5.5.2. Product Strategy
17.1.5.5.3. Channel Strategy
17.1.6. Baxter
17.1.6.1. Overview
17.1.6.2. Product Portfolio
17.1.6.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.6.4. Sales Footprint
17.1.6.5. Strategy Overview
17.1.6.5.1. Marketing Strategy
17.1.6.5.2. Product Strategy
17.1.6.5.3. Channel Strategy
17.1.7. Nuvasive, Inc.
17.1.7.1. Overview
17.1.7.2. Product Portfolio
17.1.7.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.7.4. Sales Footprint
17.1.7.5. Strategy Overview
17.1.7.5.1. Marketing Strategy
17.1.7.5.2. Product Strategy
17.1.7.5.3. Channel Strategy
17.1.8. TBF Tissue Engineering
17.1.8.1. Overview
17.1.8.2. Product Portfolio
17.1.8.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.8.4. Sales Footprint
17.1.8.5. Strategy Overview
17.1.8.5.1. Marketing Strategy
17.1.8.5.2. Product Strategy
17.1.8.5.3. Channel Strategy
17.1.9. OST Devloppement
17.1.9.1. Overview
17.1.9.2. Product Portfolio
17.1.9.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.9.4. Sales Footprint
17.1.9.5. Strategy Overview
17.1.9.5.1. Marketing Strategy
17.1.9.5.2. Product Strategy
17.1.9.5.3. Channel Strategy
17.1.10. AlloSource
17.1.10.1. Overview
17.1.10.2. Product Portfolio
17.1.10.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.10.4. Sales Footprint
17.1.10.5. Strategy Overview
17.1.10.5.1. Marketing Strategy
17.1.10.5.2. Product Strategy
17.1.10.5.3. Channel Strategy
17.1.11. Medtronic
17.1.11.1. Overview
17.1.11.2. Product Portfolio
17.1.11.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.11.4. Sales Footprint
17.1.11.5. Strategy Overview
17.1.11.5.1. Marketing Strategy
17.1.11.5.2. Product Strategy
17.1.11.5.3. Channel Strategy
17.1.12. Orthofix Holdings, Inc.
17.1.12.1. Overview
17.1.12.2. Product Portfolio
17.1.12.3. Profitability by Market Segments (Product/Age /Sales Channel/Region)
17.1.12.4. Sales Footprint
17.1.12.5. Strategy Overview
17.1.12.5.1. Marketing Strategy
17.1.12.5.2. Product Strategy
17.1.12.5.3. Channel Strategy

18. Assumptions & Acronyms Used

19. Research Methodology

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