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Protein Expression: Global Markets

Published By :

BCC Research

Published Date : Feb 2019

Category :

Biotechnology

No. of Pages : 154 Pages

Protein Expression Market: A Snapshot

Protein expression is an umbrella term used to describe the way proteins are modified, synthesized, and regulated in living organisms. The term also refers to technique used in the production of proteins.  The manufacturing of recombinant protein depends on using cellular machinery. 

Protein expression market products provide important applications for a wide variety of industries. These are particularly prominent in industrial fermentation. It is used in the creation of insulin by biopharmaceutical companies to treat diabetes. Additionally, it is also used for the creation of enzymes. 

Enzymes are used in the medical industry for treating various basic ailments such as eating disorders to critical illnesses within the blood circulation system. Enzymes are quite popular in industrial applications as well. Enzymes are widely used in agriculture, food industry, and cosmetic industry to speed up product manufacturing and control quality. Due to rising demand for enzymes in production, it continues to remain a key application in the protein expression market. 

Protein expression market products are derived from bacteria, yeast, mammalian cells, baculovirus. Recently, the use of filamentous fungi is also becoming increasingly appealing. Protein expression techniques are facing increased scrutiny world over as traces of impurities cannot be completely ruled out in final products. Hence, technique Innovation promises more applications in food and beverage sector for players in the protein expression market.  

Many manufacturers in the protein expression market work with cloned DNA. The technique is the oldest and most celebrated protein expression technique today. It empowers a cell to host a foreign gene to produce high level proteins. E.coli is a widely used host cell. This technique promises many commercial opportunities and increases the supply multifold to increase the binding strength of the foreign agent to aid transcription. 

Report Highlights

The global market for protein expression should grow from $1.8 billion in 2017 to $3.1 billion by 2022 at a compound annual growth rate (CAGR) of 11.3% from 2017 through 2022.

Summary

Protein expression is a technique where three processestranslation, transcription and posttranslational modificationplay a vital role in the various applications, including biologics production, therapeutic protein production and research application. There are three types of recombinant protein expression methods. These include in vivo protein expression, in vitro protein expression and chemical protein synthesis. It is critical to have access to a variety of expression tools to ensure the successful expression of the required target protein.

Based on the functional need in the host cell, proteins can be modified, regulated and synthesized in different living organisms. These proteins need a specific intracellular environment to achieve the required secondary and tertiary structures. Some proteins also require post-translational modifications or insertion into a cellular membrane to attain the proper functioning of the protein. In addition, the production of some proteins could also be toxic for the well-being of the host. Hence, there is no single solution for the successful production of different types of recombinant proteins.

In this report, the protein expression market is studied through different perspectives. The market is analyzed through the products and their applications in the treatment of several chronic diseases. The protein expression market is categorized into six types based on system type: prokaryotic expression system, mammalian cell expression system, insect cell expression system, yeast cell expression system, cell-free expression system and algal-based expression system. The prokaryotic expression system registered a revenue of REDACTED in 2016 and is poised to increase at a compound annual growth rate (CAGR) of REDACTED throughout the forecast period. Its revenue is projected to reach REDACTED by 2022.

The global market for protein expression based on products and services is segmented into five categories: reagents, expression vectors, competent cells, instruments and services. The reagents segment has dominated the global market for protein expression and is anticipated to do so during the forecast period. This segment accounted for a revenue of REDACTED in 2016, registering a CAGR of REDACTED; this revenue is expected to reach nearly REDACTED by 2022.

By geography, the global market for protein expression is divided into North America, Europe, Asia-Pacific and the Rest of World (ROW). North America held the largest market share in 2016 and accounted for REDACTED, growing at the CAGR of REDACTED during the analysis period. It is anticipated that market will reach nearly REDACTED by 2022. Europe held the second-largest market share of the protein expression market globally. It accounted for REDACTED in 2016 and is expected to reach REDACTED by 2022 at a CAGR of REDACTED. The Asia-Pacific market accounted for REDACTED in 2016 and is expected to reach REDACTED by 2022 at a CAGR of REDACTED. ROW includes Brazil, Saudi Arabia, and South Africa. The ROW protein expression market accounted for REDACTED in 2016 and is expected to reach REDACTED by 2022 at a CAGR of REDACTED.

Report Scope:

This research report presents an in-depth analysis of the global market for protein expression by system type, products and services, applications, end users and regional markets. The report includes key protein expression systems that are incorporated in several therapeutic treatment methods. It discusses the role of supply chain members from manufacturers to researchers. The report provides an in-depth analysis of key companies operating in the global market for protein expression. A patent analysis focuses on describing technological trends across periods of time and regions, such as the U.S., Europe and Japan.

The protein expression market is mainly segmented into the following system types: prokaryotic expression systems, mammalian cell expression systems, insect cell expression systems, yeast expression systems, cell-free expression systems and algal-based expression systems. This market is further segmented based on products and services into reagents, expression vectors, competent cells, instruments and services. The market study details end users and applications, and ongoing activity in the research and development area. The market is segmented by region into North America, Europe, Asia-Pacific and the rest of the world (ROW). Companies profiled in this report include Thermo Fisher Scientific Inc., Merck KGaA, Promega Corp., Agilent Technologies, GenScript, Takara Holdings Inc., Bio-Rad Laboratories Inc., Qiagen N.V., Lonza and others.

Report Includes:

- 45 data tables 34 additional tables
- An overview and in-depth analysis of the global markets for protein expression technologies
- Analyses of global market trends with data from 2016 and 2017, and projections of compound annual growth rates (CAGRs) through 2022
- Discussion on perfusion approaches and supporting practices such as continuous bio manufacturing, and digital and model-based controls
- Identification of key market dynamics and the factors impacting the global market for protein expression and its sub-segments
- Regional dynamics of the global protein expression market and analysis of trends and opportunities in major regions covering North America, Europe, Asia-Pacific and the rest of the world (ROW)
- A relevant patent analysis focuses on describing technological trends across periods of time and regions, such as the U.S., Europe and Japan
- Detailed analysis of the cloning technologies, production of recombinant proteins and problems associated with protein production
- Assessment of major stakeholders, product portfolios and recent developments and the competitive landscape among market leaders
- Company profiles of leading global payers, including Agilent Technologies, Bio-Rad Laboratories Inc., Merck KGaA, Promega Corp., GenScript, Thermo Fisher Scientific Inc., and Qiagen N.V.

Table of Contents
Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources and Methodology
Intended Audience
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Market and Technology Background
Market Definition
Protein Expression Market Overview
Choice of Cell Type
Choice of Plasmid
Choice of Cell Expression System
Introduction to Protein Expression Systems
Protein Synthesis Machinery
What is Protein Expression?
How Proteins Are Made
Transcription and Translation
Perfusion Approaches and Supporting Practices (e.g., Continuous Bio Manufacturing and Digital and Model-based Controls)
Post-translational Modification
Cloning Technologies
Constitutive and Inducible Promoters Commonly Used in Recombinant Protein Expression Systems
Production of Recombinant Proteins
Recombinant Protein Expression Methods
Why Produce Proteins Recombinantly?
Comparison of Expression Systems
Post-translational Processing
Problems Associated with the Production of Protein
Loss of Expression
Ongoing Clinical Trials for Protein Expression
Market Dynamics
Drivers
Restraints
Opportunities
Chapter 4 Global Market for Protein Expression Systems by Type
Introduction
Constitutive and Inducible Promoters Commonly Used in Recombinant Protein Expression Systems
Characteristics of Various Recombinant Protein Expression Systems
Prokaryotic Expression Systems
Promoters
E. coli Systems
Other Prokaryotic Expression Systems
Mammalian Cell Expression Systems
Mammalian Expression Vectors Characteristics
Chinese Hamster Ovary (CHO) Systems
Other Mammalian Cell Systems
Insect Cell Expression Systems
Baculovirus Systems
Yeast Expression Systems
K. Lactis Systems
Saccharomyces Systems
Pichia Systems
Cell-Free Expression Systems
Algal-Based Expression Systems
Chapter 5 Global Market for Protein Expression by Products and Services
Overview
Reagents
Acids and Bases
Acrylamides
Buffers/Buffer Salts
Cell Lysis
Detergents
General Reagents
Labware
Protease Inhibitors
Solvents
Expression Vectors
Commonly Used Expression Hosts
Competent Cells
Instruments
Bioreactor Systems
Services
Protein Expression Services
Benefits
Specific Services Provided by Organizations
Chapter 6 Global Market for Protein Expression by Application
Introduction
Medicine
Research
Biotechnology
Therapeutic
Traditional Recombinant and Newer Cell Therapies including Stem Cell
Industrial
Research
Chapter 7 Global Market for Protein Expression by End User
Overview
Pharmaceutical and Biotechnology Companies
Academic Research Institutes
Contract Research Organizations
Others
Chapter 8 Global Market for Protein Expression by Region
North America
U.S.
Canada
Mexico
Europe
U.K.
Germany
France
Rest of Europe
Asia-Pacific
China
Japan
Australia
India
South Korea
Taiwan
Rest of Asia
ROW
Brazil
Saudi Arabia
South Africa
Others
Chapter 9 Government Regulations
General Manufacturing Guidelines
Control of Starting/Source Materials
Expression Vector and Host Cell
Cell Bank System
Cell Culture Medium/Other Materials
Control of the Manufacturing Process
Cell Culture
Purification
Control of Drug Substance and Drug Product
Characterization
Routine Control
Chapter 10 Patent Review
Patent Analysis
Patents and Patent Applications Filed by Institutions
Chapter 11 Competitive Landscape
Acquisition
Thermo Fisher Scientific Acquired Affymetrix
Product Launches
Chapter 12 Company Profiles
ABNOVA (TAIWAN) CORP.
ACCELAGEN INC.
AGILENT TECHNOLOGIES INC.
BIOMATIK
BIO-RAD LABORATORIES INC.
DOMAINEX LTD.
ENZO LIFE SCIENCES INC.
EXON BIOSYSTEMS
GENSCRIPT
LONZA GROUP AG
LUCIGEN CORP.
MERCK KGAA
NEW ENGLAND BIOLABS INC.
NOVOPROTEIN SCIENTIFIC INC.
ORIGENE TECHNOLOGIES INC.
OXFORD EXPRESSION TECHNOLOGIES LTD.
PROMEGA CORP.
PROTEOGENIX INC.
QIAGEN INC.
R&D SYSTEMS INC.
SINO BIOLOGICAL INC.
SYNGENE
SYNTHETIC GENOMICS INC.
TAKARA HOLDINGS, INC.
THERMO FISHER SCIENTIFIC INC.
Chapter 13 Appendix: Uses of Protein Expressions Systems

List of Table

List of Tables
Summary Table : Global Market for Protein Expression, by Region, Through 2022
Table 1 : Advantages and Disadvantages of Protein Expression Systems
Table 2 : Prokaryotes vs. Eukaryotes Protein Synthesis
Table 3 : Comparison of Expression Systems
Table 4 : Ongoing Clinical Trials (List 1)
Table 5 : Ongoing Clinical Trials (List 2)
Table 6 : Global Market for Protein Expression Systems, by Type, Through 2022
Table 7 : Comparison of Protein Expression Systems and Their Respective Advantages and Disadvantages
Table 8 : Uses of Constitutive and Inducible Promoters in Recombinant Protein Expression Systems
Table 9 : Advantages, Challenges and Most Common Applications of Protein Expression Systems
Table 10 : Global Market for Prokaryotic Expression Systems, by Region, Through 2022
Table 11 : Overview of E. coli Promoter Systems Useful for Heterologous Protein Production
Table 12 : Bacterial Strains for Protein Expression
Table 13 : Global Market for Mammalian Cell Expression System, by Region, Through 2022
Table 14 : Global Market for Insect Cell Expression Systems, by Region, Through 2022
Table 15 : Global Market for Yeast Expression System, by Region, Through 2022
Table 16 : Global Market for Cell-Free Systems, by Region, Through 2022
Table 17 : Global Market for Algal Expression Systems, by Region, Through 2022
Table 18 : Global Market for Protein Expression, by Products and Services, Through 2022
Table 19 : Global Market for Reagents, by Region, Through 2022
Table 20 : Products: Acids and Bases
Table 21 : Products: Acrylamides
Table 22 : Products: Buffers/Buffer Salts
Table 23 : Products: Cell Lysis
Table 24 : Products: Detergents
Table 25 : Products: General Reagents
Table 26 : Products: Labware
Table 27 : Products: Protease Inhibitors
Table 28 : Products: Solvents
Table 29 : Global Market for Vector Products, by Region, Through 2022
Table 30 : Characteristics of the Commonly Used Expression Hosts
Table 31 : Global Market for Competent Cells Products, by Region, Through 2022
Table 32 : Features of Component Cells
Table 33 : Global Market for Instruments, by Region, Through 2022
Table 34 : Global Market for Services, by Region, Through 2022
Table 35 : Specific Services Provided by Organizations
Table 36 : GenScript Services by Category of Protein Expression
Table 37 : Global Market for Protein Expression, by Application, Through 2022
Table 38 : Global Market for Therapeutic Applications, by Region, Through 2022
Table 39 : Global Market for Industrial Applications, by Region, Through 2022
Table 40 : Global Market for Research Applications, by Region, Through 2022
Table 41 : Global Market for Protein Expression, by End User, Through 2022
Table 42 : Global Market for Pharmaceutical End Users of Protein Expression, by Region, Through 2022
Table 43 : Global Market for Academic Research Institute End Users of Protein Expression, by Region, Through 2022
Table 44 : Global Market for Contract Research Organization End Users of Protein Expression, by Region, Through 2022
Table 45 : Global Market for Other End Users of Protein Expression, by Region, Through 2022
Table 46 : Global Market for Protein Expression, by Region, Through 2022
Table 47 : North American Market for Protein Expression, by Country, Through 2022
Table 48 : North American Market for Protein Expression, by Products, Through 2022
Table 49 : North American Market for Protein Expression Systems, by Type, Through 2022
Table 50 : North American Market for Protein Expression, by Application, Through 2022
Table 51 : North American Market for Protein Expression, by End User, Through 2022
Table 52 : European Market for Protein Expression, by Country, Through 2022
Table 53 : European Market for Protein Expression, by Products and Services, Through 2022
Table 54 : European Market for Protein Expression Systems, by Type, Through 2022
Table 55 : European Market for Protein Expression, by Application, Through 2022
Table 56 : European Market for Protein Expression, by End User, Through 2022
Table 57 : Asia-Pacific Market for Protein Expression, by Country, Through 2022
Table 58 : Asia-Pacific Market for Protein Expression, by Products and Services, Through 2022
Table 59 : Asia-Pacific Market for Protein Expression Systems, by Type, Through 2022
Table 60 : Asia-Pacific Market for Protein Expression, by Application, Through 2022
Table 61 : Asia-Pacific Market for Protein Expression, by End User, Through 2022
Table 62 : ROW Market for Protein Expression, by Country, Through 2022
Table 63 : ROW Market for Protein Expression, by Products and Services, Through 2022
Table 64 : ROW Market for Protein Expression Systems, by Type, Through 2022
Table 65 : ROW Market for Protein Expression, by Application, Through 2022
Table 66 : ROW Market for Protein Expression, by End User, Through 2022
Table 67 : Significant U.S. Patents and Patent Applications on Protein Expression, 2015-2018
Table 68 : Significant European Patents and Patent Applications on Protein Expression, 2015-2018
Table 69 : Significant Japanese Patents and Patent Applications on Protein Expression, 2015-2018
Table 70 : U.S. Patents Filed on Protein Expression Technologies by Institutions, 2015-2018
Table 71 : Abnova (Taiwan) Corp. Products
Table 72 : Biomatik Products
Table 73 : GenScript Products
Table 74 : Lucigen Products
Table 75 : Protein Production Service in HEK293 Cells
Table 76 : Protein Production Service in E. coli Cells
Table 77 : Protein Production Service in Insect Cell Culture/Baculovirus Expression
Table 78 : CHO Cell Transient Transfection Service

List of Chart

List of Figures
Summary Figure : Global Market for Protein Expression, by Region, 2016-2022
Figure 1 : Protein Expression Workflow
Figure 2 : Share of Clinical Trials Performed for Protein Expression, by Region, 2009-2018
Figure 3 : Patents Shares of Protein Expression Technologies, by Region, 2015-2018

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