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Pain Drug Development Pipeline Review, 2017

Published By :

GBI Research

Published Date : Jul 2017

Category :

Pharmaceutical

No. of Pages : 229 Pages

Pain Drug Development Pipeline Review, 2017

Summary

This report provides an overview of the pain pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for Osteoarthritis Pain, Migraine pain and Neuropathic Pain, therefore covering a number of the most difficult-to-treat chronic and acute pain subtypes.

Osteoarthritis pain is the most common symptom associated with osteoarthritis which causes disruption of the cartilage. This further leads to rubbing of the bones against each other stimulating pain. Migraine is a disorder characterized by repeated attacks of severe headache. A migraine headache causes throbbing or pulsating pain, usually on only one side of the head. These headaches are often associated with nausea, vomiting, and extreme sensitivity to light and sound. Finally neuropathic pain, or neuralgia, is a condition in which the sensory system is affected. It is commonly accompanied by tissue injury, in which the nerve fibres could be damaged resulting in the generation of abnormal signals. However, it is exhibited in a range of diseases and has no specific identifiable cause.

The size of these pipelines ranges from 62 products in osteoarthritis pain to 249 in neuropathic pain. Within osteoarthritis pain, prostaglandin G/H synthases 1 and 2 and the nerve growth factor receptors are being studied by the most pipeline products; while the prostaglandin receptors are frequently targeted by already approved marketed products, the nerve growth factor receptors are not.

In migraine, it is the 5-hydroxytryptamine (serotonin) receptors 1D and 1B which are being most frequently studied, again reflecting the composition of the market for this indication. However, the calcitonin gene related peptide and its receptor, also very frequently targeted, are not yet present in the migraine market. Finally, the favoured targets of neuropathic pain are the sodium channel protein type 9 (Nav1.9) and the mu type opioid receptor. While the latter is already heavily targeted in the pain market, the former is not.

Scope

- Which companies are the most active within the pipeline for pain therapeutics?
- Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
- To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
- What are the most important R&D milestones and data publications to have happened in the field of pain therapeutics?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration
Table of Contents
GBI Research Report Guidance 2
Executive Summary 3
Table of Contents 4
List of Tables 5
List of Figures 11
Introduction 12
GBI Research Report Coverage 12
Osteoarthritis Pain - Overview 12
Migraine - Overview 12
Neuropathic Pain - Overview 12
Therapeutics Development 13
Osteoarthritis Pain 13
Migraine 20
Neuropathic Pain 28
Therapeutics Assessment 45
Osteoarthritis Pain 45
Migraine 55
Neuropathic Pain 65
Companies Involved in Therapeutics Development 78
Osteoarthritis Pain 78
Migraine 98
Neuropathic Pain 117
Dormant Projects 177
Osteoarthritis Pain 177
Migraine 179
Neuropathic Pain 182
Discontinued Products 191
Osteoarthritis Pain 191
Migraine 192
Neuropathic Pain 193
Product Development Milestones 196
Osteoarthritis Pain 196
Migraine 206
Neuropathic Pain 217
Appendix 228
Methodology 228
Coverage 228
Secondary Research 228
Primary Research 228
Expert Panel Validation 228
Contact Us 228
Disclaimer 229

List of Tables
Number of Products under Development for Osteoarthritis Pain 13
Number of Products under Development by Companies, Osteoarthritis Pain 15
Number of Products under Development by Universities/Institutes, Osteoarthritis Pain 17
Products under Development by Companies, Osteoarthritis Pain 18
Products under Development by Universities/Institutes, Osteoarthritis Pain 19
Number of Products under Development for Migraine 20
Number of Products under Development by Companies, Migraine 22
Number of Products under Development by Universities/Institutes, Migraine 24
Products under Development by Companies, Migraine 25
Products under Development by Universities/Institutes, Migraine 27
Number of Products under Development for Neuropathic Pain 28
Number of Products under Development by Companies, Neuropathic Pain 30
Number of Products under Development by Universities/Institutes, Neuropathic Pain 35
Products under Development by Companies, Neuropathic Pain 36
Products under Development by Universities/Institutes, Neuropathic Pain 43
Number of Products by Stage and Target, Osteoarthritis Pain 46
Number of Products by Stage and Mechanism of Action, Osteoarthritis Pain 49
Number of Products by Stage and Route of Administration, Osteoarthritis Pain 52
Number of Products by Stage and Molecule Type, Osteoarthritis Pain 54
Number of Products by Stage and Target, Migraine 56
Number of Products by Stage and Mechanism of Action, Migraine 59
Number of Products by Stage and Route of Administration, Migraine 62
Number of Products by Stage and Molecule Type, Migraine 64
Number of Products by Stage and Target, Neuropathic Pain 66
Number of Products by Stage and Mechanism of Action, Neuropathic Pain 70
Number of Products by Stage and Route of Administration, Neuropathic Pain 75
Number of Products by Stage and Molecule Type, Neuropathic Pain 77
Osteoarthritis Pain - Pipeline by AbbVie Inc 78
Osteoarthritis Pain - Pipeline by Addex Therapeutics Ltd 78
Osteoarthritis Pain - Pipeline by Allergan Plc 79
Osteoarthritis Pain - Pipeline by Ampio Pharmaceuticals Inc 79
Osteoarthritis Pain - Pipeline by Antibe Therapeutics Inc 80
Osteoarthritis Pain - Pipeline by Aralez Pharmaceuticals Inc 80
Osteoarthritis Pain - Pipeline by Arena Pharmaceuticals Inc 81
Osteoarthritis Pain - Pipeline by Array BioPharma Inc 81
Osteoarthritis Pain - Pipeline by Astellas Pharma Inc 82
Osteoarthritis Pain - Pipeline by Axsome Therapeutics Inc 82
Osteoarthritis Pain - Pipeline by BELLUS Health Inc 83
Osteoarthritis Pain - Pipeline by Boehringer Ingelheim GmbH 83
Osteoarthritis Pain - Pipeline by Cara Therapeutics Inc 84
Osteoarthritis Pain - Pipeline by Chromocell Corp 84
Osteoarthritis Pain - Pipeline by Eli Lilly and Company 85
Osteoarthritis Pain - Pipeline by Elite Pharmaceuticals Inc 85
Osteoarthritis Pain - Pipeline by Eupraxia Pharmaceuticals Inc 86
Osteoarthritis Pain - Pipeline by Flexion Therapeutics Inc 86
Osteoarthritis Pain - Pipeline by Genzyme Corp 87
Osteoarthritis Pain - Pipeline by GlaxoSmithKline Plc 87
Osteoarthritis Pain - Pipeline by Grunenthal GmbH 88
Osteoarthritis Pain - Pipeline by Iroko Pharmaceuticals LLC 88
Osteoarthritis Pain - Pipeline by Marina Biotech Inc 89
Osteoarthritis Pain - Pipeline by Medestea Research & Production SpA 89
Osteoarthritis Pain - Pipeline by MedImmune LLC 90
Osteoarthritis Pain - Pipeline by Merck & Co Inc 90
Osteoarthritis Pain - Pipeline by Nuvo Pharmaceuticals Inc 91
Osteoarthritis Pain - Pipeline by Ono Pharmaceutical Co Ltd 91
Osteoarthritis Pain - Pipeline by Pfizer Inc 92
Osteoarthritis Pain - Pipeline by Phosphagenics Ltd 92
Osteoarthritis Pain - Pipeline by ProteoThera Inc 93
Osteoarthritis Pain - Pipeline by pSivida Corp 93
Osteoarthritis Pain - Pipeline by Purdue Pharma LP 94
Osteoarthritis Pain - Pipeline by Regeneron Pharmaceuticals Inc 94
Osteoarthritis Pain - Pipeline by Rottapharm Biotech Srl 95
Osteoarthritis Pain - Pipeline by Shionogi & Co Ltd 95
Osteoarthritis Pain - Pipeline by Symic Biomedical Inc 96
Osteoarthritis Pain - Pipeline by Taiwan Liposome Company Ltd 96
Osteoarthritis Pain - Pipeline by Vertex Pharmaceuticals Inc 97
Osteoarthritis Pain - Pipeline by Zynerba Pharmaceuticals Inc 97
Migraine - Pipeline by 4P Therapeutics LLC 98
Migraine - Pipeline by Achelios Therapeutics Inc 98
Migraine - Pipeline by Acorda Therapeutics Inc 99
Migraine - Pipeline by Alder Biopharmaceuticals Inc 99
Migraine - Pipeline by Allergan Plc 100
Migraine - Pipeline by Amgen Inc 100
Migraine - Pipeline by Aralez Pharmaceuticals Inc 101
Migraine - Pipeline by Astellas Pharma Inc 101
Migraine - Pipeline by Avanir Pharmaceuticals Inc 102
Migraine - Pipeline by Biofrontera AG 102
Migraine - Pipeline by BioHealthonomics Inc 103
Migraine - Pipeline by Charleston Laboratories Inc 103
Migraine - Pipeline by Corium International Inc 104
Migraine - Pipeline by Eli Lilly and Company 104
Migraine - Pipeline by Impel NeuroPharma Inc 105
Migraine - Pipeline by InKemia IUCT Group SA 105
Migraine - Pipeline by InStar Technologies AS 106
Migraine - Pipeline by Ionis Pharmaceuticals Inc 106
Migraine - Pipeline by Klaria Pharma Holding AB 107
Migraine - Pipeline by Medestea Research & Production SpA 107
Migraine - Pipeline by Merck & Co Inc 108
Migraine - Pipeline by Monosol Rx LLC 108
Migraine - Pipeline by NAL Pharmaceuticals Ltd 109
Migraine - Pipeline by Promius Pharma LLC 109
Migraine - Pipeline by RedHill Biopharma Ltd 110
Migraine - Pipeline by Revance Therapeutics Inc 110
Migraine - Pipeline by Shin Nippon Biomedical Laboratories Ltd 111
Migraine - Pipeline by Suda Ltd 111
Migraine - Pipeline by Teva Pharmaceutical Industries Ltd 112
Migraine - Pipeline by TheraJect Inc 112
Migraine - Pipeline by Tonix Pharmaceuticals Holding Corp 113
Migraine - Pipeline by Trevena Inc 113
Migraine - Pipeline by Trigemina Inc 114
Migraine - Pipeline by TrioxBio Inc 114
Migraine - Pipeline by Vertex Pharmaceuticals Inc 115
Migraine - Pipeline by Xenon Pharmaceuticals Inc 115
Migraine - Pipeline by Zosano Pharma Corp 116
Neuropathic Pain - Pipeline by 2-BBB Medicines BV 117
Neuropathic Pain - Pipeline by AbbVie Inc 117
Neuropathic Pain - Pipeline by Abide Therapeutics Inc 118
Neuropathic Pain - Pipeline by Acadia Pharmaceuticals Inc 118
Neuropathic Pain - Pipeline by Achelios Therapeutics Inc 119
Neuropathic Pain - Pipeline by Aevi Genomic Medicine Inc 119
Neuropathic Pain - Pipeline by Affectis Pharmaceuticals AG 120
Neuropathic Pain - Pipeline by Amura Holdings Ltd 120
Neuropathic Pain - Pipeline by AnaBios Corp 121
Neuropathic Pain - Pipeline by Anavex Life Sciences Corp 121
Neuropathic Pain - Pipeline by AngioChem Inc 122
Neuropathic Pain - Pipeline by Apollo Endosurgery Inc 122
Neuropathic Pain - Pipeline by Aptinyx Inc 123
Neuropathic Pain - Pipeline by Arena Pharmaceuticals Inc 123
Neuropathic Pain - Pipeline by Asahi Kasei Pharma Corp 124
Neuropathic Pain - Pipeline by Astellas Pharma Inc 124
Neuropathic Pain - Pipeline by AstraZeneca Plc 125
Neuropathic Pain - Pipeline by Aucta Pharmaceuticals LLC 125
Neuropathic Pain - Pipeline by BCI Pharma 126
Neuropathic Pain - Pipeline by BCN Peptides SA 126
Neuropathic Pain - Pipeline by Biogen Inc 127
Neuropathic Pain - Pipeline by Biomar Microbial Technologies 127
Neuropathic Pain - Pipeline by Bionomics Ltd 128
Neuropathic Pain - Pipeline by Bristol-Myers Squibb Company 128
Neuropathic Pain - Pipeline by Can-Fite BioPharma Ltd 129
Neuropathic Pain - Pipeline by Cara Therapeutics Inc 129
Neuropathic Pain - Pipeline by Cavion LLC 130
Neuropathic Pain - Pipeline by Celgene Corp 130
Neuropathic Pain - Pipeline by Cerecor Inc 131
Neuropathic Pain - Pipeline by Chromocell Corp 131
Neuropathic Pain - Pipeline by Circuit Therapeutics Inc 132
Neuropathic Pain - Pipeline by CLL Pharma SA 132
Neuropathic Pain - Pipeline by Colby Pharmaceutical Company 133
Neuropathic Pain - Pipeline by ConSynance Therapeutics Inc 133
Neuropathic Pain - Pipeline by ContraVir Pharmaceuticals Inc 134
Neuropathic Pain - Pipeline by Crinetics Pharmaceuticals Inc 134
Neuropathic Pain - Pipeline by Cytogel Pharma LLC 135
Neuropathic Pain - Pipeline by Daewoong Pharmaceutical Co Ltd 135
Neuropathic Pain - Pipeline by Daiichi Sankyo Company Ltd 136
Neuropathic Pain - Pipeline by Develco Pharma Schweiz AG 136
Neuropathic Pain - Pipeline by Dompe Farmaceutici SpA 137
Neuropathic Pain - Pipeline by Eisai Co Ltd 137
Neuropathic Pain - Pipeline by Eli Lilly and Company 138
Neuropathic Pain - Pipeline by Endece LLC 138
Neuropathic Pain - Pipeline by Evec Inc 139
Neuropathic Pain - Pipeline by Genecode AS 139
Neuropathic Pain - Pipeline by GL Pharm Tech Corp 140
Neuropathic Pain - Pipeline by Glenmark Pharmaceuticals Ltd 140
Neuropathic Pain - Pipeline by Glialogix Inc 141
Neuropathic Pain - Pipeline by Grunenthal GmbH 141
Neuropathic Pain - Pipeline by GW Pharmaceuticals Plc 142
Neuropathic Pain - Pipeline by Hydra Biosciences Inc 142
Neuropathic Pain - Pipeline by Immune Pharmaceuticals Inc 143
Neuropathic Pain - Pipeline by InMed Pharmaceuticals Inc 143
Neuropathic Pain - Pipeline by Intec Pharma ltd 144
Neuropathic Pain - Pipeline by Integral Molecular Inc 144
Neuropathic Pain - Pipeline by Intellipharmaceutics International Inc 145
Neuropathic Pain - Pipeline by Jeil Pharmaceutical Co Ltd 145
Neuropathic Pain - Pipeline by Jiangsu Hengrui Medicine Co Ltd 146
Neuropathic Pain - Pipeline by Jiangsu Nhwa Pharmaceutical Corp Ltd 146
Neuropathic Pain - Pipeline by Johnson & Johnson 147
Neuropathic Pain - Pipeline by JT Pharmaceuticals Inc 147
Neuropathic Pain - Pipeline by Knopp Biosciences LLC 148
Neuropathic Pain - Pipeline by Kolon Life Science Inc 148
Neuropathic Pain - Pipeline by KPI Therapeutics Inc 149
Neuropathic Pain - Pipeline by Lexicon Pharmaceuticals Inc 149
Neuropathic Pain - Pipeline by Lohocla Research Corp 150
Neuropathic Pain - Pipeline by Mapi Pharma Ltd 150
Neuropathic Pain - Pipeline by MD Biosciences GmbH 151
Neuropathic Pain - Pipeline by Medestea Research & Production SpA 151
Neuropathic Pain - Pipeline by Medifron DBT Co Ltd 152
Neuropathic Pain - Pipeline by MEDRx Co Ltd 152
Neuropathic Pain - Pipeline by Medy-Tox Inc 153
Neuropathic Pain - Pipeline by Merck & Co Inc 153
Neuropathic Pain - Pipeline by Mitsubishi Tanabe Pharma Corp 154
Neuropathic Pain - Pipeline by Mundipharma International Ltd 154
Neuropathic Pain - Pipeline by Nanomerics Ltd 155
Neuropathic Pain - Pipeline by Neurim Pharmaceuticals Ltd 155
Neuropathic Pain - Pipeline by Neurocentrx Pharma Ltd 156
Neuropathic Pain - Pipeline by NeuroCycle Therapeutics GmbH 156
Neuropathic Pain - Pipeline by NeurOp Inc 157
Neuropathic Pain - Pipeline by Newron Pharmaceuticals SpA 157
Neuropathic Pain - Pipeline by Nippon Chemiphar Co Ltd 158
Neuropathic Pain - Pipeline by NoNO Inc 158
Neuropathic Pain - Pipeline by Novaremed Ltd 159
Neuropathic Pain - Pipeline by Novartis AG 159
Neuropathic Pain - Pipeline by Omeros Corp 160
Neuropathic Pain - Pipeline by Orion Oyj 160
Neuropathic Pain - Pipeline by Patagonia Pharmaceuticals LLC 161
Neuropathic Pain - Pipeline by PeriphaGen Inc 161
Neuropathic Pain - Pipeline by Pfizer Inc 162
Neuropathic Pain - Pipeline by Pharmaleads SA 162
Neuropathic Pain - Pipeline by Phosphagenics Ltd 163
Neuropathic Pain - Pipeline by Prismic Pharmaceuticals Inc 163
Neuropathic Pain - Pipeline by RaQualia Pharma Inc 164
Neuropathic Pain - Pipeline by Re-Pharm Ltd 164
Neuropathic Pain - Pipeline by Reata Pharmaceuticals Inc 165
Neuropathic Pain - Pipeline by Relmada Therapeutics Inc 165
Neuropathic Pain - Pipeline by Revance Therapeutics Inc 166
Neuropathic Pain - Pipeline by Rottapharm Biotech Srl 166
Neuropathic Pain - Pipeline by Saniona AB 167
Neuropathic Pain - Pipeline by Scilex Pharmaceuticals Inc 167
Neuropathic Pain - Pipeline by Shionogi & Co Ltd 168
Neuropathic Pain - Pipeline by SK Biopharmaceuticals Co Ltd 168
Neuropathic Pain - Pipeline by Sunovion Pharmaceuticals Inc 169
Neuropathic Pain - Pipeline by Syntrix Biosystems Inc 169
Neuropathic Pain - Pipeline by Takeda Pharmaceutical Company Ltd 170
Neuropathic Pain - Pipeline by Teva Pharmaceutical Industries Ltd 170
Neuropathic Pain - Pipeline by Theranexus SAS 171
Neuropathic Pain - Pipeline by Toray Industries Inc 171
Neuropathic Pain - Pipeline by Torrent Pharmaceuticals Ltd 172
Neuropathic Pain - Pipeline by Trevena Inc 172
Neuropathic Pain - Pipeline by Virobay Inc 173
Neuropathic Pain - Pipeline by VistaGen Therapeutics Inc 173
Neuropathic Pain - Pipeline by Vitality Biopharma Inc 174
Neuropathic Pain - Pipeline by Yooyoung Pharm Co Ltd 174
Neuropathic Pain - Pipeline by Yuhan Corp 175
Neuropathic Pain - Pipeline by Yungjin Pharm Co Ltd 175
Neuropathic Pain - Pipeline by Zynerba Pharmaceuticals Inc 176
Osteoarthritis Pain - Dormant Projects 177
Migraine - Dormant Projects 179
Neuropathic Pain - Dormant Projects 182
Osteoarthritis Pain - Discontinued Products 191
Migraine - Discontinued Products 192
Neuropathic Pain - Discontinued Products 193

List of Figures
Number of Products under Development for Osteoarthritis Pain 13
Number of Products under Development by Companies, Osteoarthritis Pain 14
Number of Products under Development by Universities/Institutes, Osteoarthritis Pain 17
Number of Products under Development for Migraine 20
Number of Products under Development by Companies, Migraine 21
Number of Products under Development by Universities/Institutes, Migraine 24
Number of Products under Development for Neuropathic Pain 28
Number of Products under Development by Companies, Neuropathic Pain 29
Number of Products under Development by Universities/Institutes, Neuropathic Pain 34
Number of Products by Top 10 Targets, Osteoarthritis Pain 45
Number of Products by Stage and Top 10 Targets, Osteoarthritis Pain 45
Number of Products by Top 10 Mechanism of Actions, Osteoarthritis Pain 48
Number of Products by Stage and Top 10 Mechanism of Actions, Osteoarthritis Pain 48
Number of Products by Routes of Administration, Osteoarthritis Pain 51
Number of Products by Stage and Routes of Administration, Osteoarthritis Pain 51
Number of Products by Molecule Types, Osteoarthritis Pain 53
Number of Products by Stage and Molecule Types, Osteoarthritis Pain 53
Number of Products by Top 10 Targets, Migraine 55
Number of Products by Stage and Top 10 Targets, Migraine 55
Number of Products by Top 10 Mechanism of Actions, Migraine 58
Number of Products by Stage and Top 10 Mechanism of Actions, Migraine 58
Number of Products by Top 10 Routes of Administration, Migraine 61
Number of Products by Stage and Top 10 Routes of Administration, Migraine 61
Number of Products by Molecule Types, Migraine 63
Number of Products by Stage and Molecule Types, Migraine 63
Number of Products by Top 10 Targets, Neuropathic Pain 65
Number of Products by Stage and Top 10 Targets, Neuropathic Pain 65
Number of Products by Top 10 Mechanism of Actions, Neuropathic Pain 69
Number of Products by Stage and Top 10 Mechanism of Actions, Neuropathic Pain 69
Number of Products by Top 10 Routes of Administration, Neuropathic Pain 74
Number of Products by Stage and Top 10 Routes of Administration, Neuropathic Pain 74
Number of Products by Top 10 Molecule Types, Neuropathic Pain 76
Number of Products by Stage and Top 10 Molecule Types, Neuropathic Pain 76

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