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MicroRNA Research Tools, Diagnostics and Therapeutics: Global Markets

Published By :

BCC Research

Published Date : Sep 2017

Category :

Biotechnology

No. of Pages : 155 Pages


The global market for induced pluripotent stem cells (iPSCs) reached $2.1 billion in 2016. The market should reach $3.6 billion in 2021, increasing at a compound annual growth rate (CAGR) of 11.6% from 2016 through 2021.
The U.S. market for iPSCs reached over $1.0 billion in 2016. The market should reach $1.8 billion in 2021, increasing at a CAGR of 11.3% from 2016 through 2021.
Asia-Pacific market for iPSCs reached $449 million in 2016. The market should reach $854 million in 2021, increasing at a CAGR of 12.3% from 2016 through 2021.
Table of Contents Table of Contents Table of Contents Table of Contents Table of Contents Table of Contents
Chapter 1: Introduction ......................................................................................... 2
Study Goals and Objectives........................................................................................................................... 2
Reasons for Doing This Study ........................................................................................................................ 2
Scope of Report ............................................................................................................................................. 3
Information Sources ...................................................................................................................................... 3
Methodology ................................................................................................................................................. 4
Geographic Breakdown ................................................................................................................................. 4
Analyst's Credentials ..................................................................................................................................... 8
Related BCC Research Reports...................................................................................................................... 8
Chapter 2: Summary and Highlights ..................................................................... 10
Chapter 3: Market and Technology Background ................................................. 14
Some Related Terms ................................................................................................................................... 14
Eukaryotes ............................................................................................................................................... 14
Genes ....................................................................................................................................................... 14
Genetic Engineering ................................................................................................................................ 14
Prokaryotes ............................................................................................................................................. 14
Transcription ........................................................................................................................................... 14
Translation ............................................................................................................................................... 14
Introduction ................................................................................................................................................ 14
Overview ................................................................................................................................................. 15
Background Genetic Material ................................................................................................................... 15
Types of RNA ............................................................................................................................................... 16
Messenger RNA (mRNA).......................................................................................................................... 17
Ribosomal RNA (rRNA) ............................................................................................................................ 17
Transfer RNA (tRNA) ................................................................................................................................ 17
MicroRNAs (miRNA) ................................................................................................................................ 17
Small Interfering RNAs (siRNA) ................................................................................................................ 17
Small Nucleolar RNA (snoRNA) ................................................................................................................ 17
History of MicroRNA Research Tools .......................................................................................................... 18
Biogenesis of MicroRNA .......................................................................................................................... 19
The Function of MicroRNA ...................................................................................................................... 21
MicroRNAs Associated with Human Diseases ......................................................................................... 21
Role of microRNAs In Various Diseases ................................................................................................... 24
Applications of MicroRNA ........................................................................................................................... 25
Research Tools......................................................................................................................................... 25
MicroRNA in Therapeutics ...................................................................................................................... 26
More on MicroRNA in Therapeutics ........................................................................................................ 28
MicroRNA in Diagnostics ......................................................................................................................... 29
MicroRNA Service Providers .................................................................................................................... 31
MicroRNA Tools and Technologies ............................................................................................................. 32
MiRNA Isolation Tools ............................................................................................................................. 33
MiRNA Microarray Tools ......................................................................................................................... 33
Reverse TranscriptionQuantitative PCR (RTqPCR) .............................................................................. 34
NextGeneration Sequencing ................................................................................................................. 35
MicroRNA Fluorescence in Situ Hybridization (miRNA FISH) .................................................................. 35
Bioinformatics: Applications in MicroRNA Research .............................................................................. 36
Computational Tools ................................................................................................................................... 36
miRanda ................................................................................................................................................... 36
MiRanda mirSVR .................................................................................................................................... 37
TargetScan ............................................................................................................................................... 37
DIANAmicro TCDS ................................................................................................................................ 37
MirTarget2 ............................................................................................................................................... 37
rna22GUI ............................................................................................................................................. 37
TargetMiner ............................................................................................................................................. 37
SVMicrO ................................................................................................................................................... 38
Probability of Interaction by Target Accessibility (PITA) ......................................................................... 38
RNAhybrid ............................................................................................................................................... 38
MicroRNA Databases .................................................................................................................................. 38
miRBase Database ................................................................................................................................... 38
DeepBase ................................................................................................................................................. 39
microRNA.org .......................................................................................................................................... 39
MiRGen 3.0 .............................................................................................................................................. 40
MiRNAMap .............................................................................................................................................. 40
Plant Microrna Database (PMRD) ........................................................................................................... 40
Chapter 4: Market Breakdown by Technology Type ............................................ 42
Market by Type ........................................................................................................................................... 42
Market Overview ..................................................................................................................................... 43
Market Revenue ...................................................................................................................................... 44
Market Share ........................................................................................................................................... 46
Bioinformatics: Applications in MicroRNA Research .................................................................................. 47
Market Overview ..................................................................................................................................... 47
Market Revenue ...................................................................................................................................... 48
Market Share ........................................................................................................................................... 49
Chapter 5: Market Breakdown by End User ........................................................ 52
Global MiRNA Market by End Users ........................................................................................................... 52
Research .................................................................................................................................................. 52
Therapeutics ............................................................................................................................................ 52
Diagnostics .............................................................................................................................................. 53
Service ..................................................................................................................................................... 53
Market Overview ..................................................................................................................................... 53
Market Revenue ...................................................................................................................................... 54
Market Share ........................................................................................................................................... 56
MicroRNA Tools Used for Research ........................................................................................................ 57
MicroRNA Tools Used for Therapeutics .................................................................................................. 59
MicroRNA Tools Used by the Service Sector ........................................................................................... 62
MicroRNA Tools Used for Diagnostic ...................................................................................................... 65
Chapter 6: Market Breakdown by Application .................................................... 70
Global Market for MicroRNA Tools by Application ..................................................................................... 71
Market Overview ..................................................................................................................................... 71
Market Revenue ...................................................................................................................................... 72
Market Share ........................................................................................................................................... 73
MicroRNA Tools Used for Cancer Diseases ............................................................................................. 74
MicroRNA Tools Used for Cardiovascular Diseases ................................................................................. 77
MicroRNA Tools Used for Immunological Diseases ................................................................................ 80
MicroRNA Tools Used for Neurological Diseases .................................................................................... 82
MicroRNA Tools Used for Metabolic Disorders ...................................................................................... 84
MicroRNA Tools Used for Other Applications ......................................................................................... 87
Chapter 7: Market Breakdown by Region ............................................................ 91
Market Overview ........................................................................................................................................ 91
Market Revenue .......................................................................................................................................... 92
Market Share .............................................................................................................................................. 94
MicroRNA Microarray ................................................................................................................................. 95
Market Overview ..................................................................................................................................... 95
Market Revenue ...................................................................................................................................... 96
Quantitative Reverse Transcription Polymerase Chain Reaction (qRTPCR) ............................................. 97
Market Overview ..................................................................................................................................... 98
Market Revenue ...................................................................................................................................... 98
Next-Generation Sequencing (NGS) ......................................................................................................... 100
Market Overview ................................................................................................................................... 101
Market Revenue .................................................................................................................................... 101
Isolation, Purification and Detection Tools ............................................................................................... 102
Market Overview ................................................................................................................................... 103
Market Revenue .................................................................................................................................... 103
MicroRNA Fluorescence in Situ Hybridization (MiRNA FISH) ................................................................... 105
Market Overview ................................................................................................................................... 105
Market Revenue .................................................................................................................................... 105
Other Tools ............................................................................................................................................... 107
Market Overview ................................................................................................................................... 108
Market Revenue .................................................................................................................................... 108
Chapter 8: Industry Structure ............................................................................ 111
MicroRNA Microarray ............................................................................................................................... 111
Market Leaders ..................................................................................................................................... 111
Market Share ......................................................................................................................................... 112
Quantitative Reverse Transcription Polymerase Chain Reaction (QRTPCR) ........................................... 113
Market Leaders ..................................................................................................................................... 113
Market Share ......................................................................................................................................... 114
NextGeneration Sequencing (NGS) ......................................................................................................... 116
Market Leaders ..................................................................................................................................... 116
Market Share ......................................................................................................................................... 116
Isolation, Purification & Detection Tools .................................................................................................. 118
Market Leaders ..................................................................................................................................... 118
Market Share ......................................................................................................................................... 118
MicroRNA Fluorescence in Situ Hybridization (FISH) ................................................................................ 120
Market Leaders ..................................................................................................................................... 120
Market Share ......................................................................................................................................... 121
Other Tools ............................................................................................................................................... 122
Market Leaders ..................................................................................................................................... 122
Market Share ......................................................................................................................................... 123
Chapter 9: Patent Review/ New Developments ................................................. 125
Patents by Year ......................................................................................................................................... 125
Patents by Type ......................................................................................................................................... 126
Patents by Company ................................................................................................................................. 127
Patents by Country.................................................................................................................................... 129
Patents by Assignee .................................................................................................................................. 131
New Products and Developments ............................................................................................................ 132
Pipeline Products ...................................................................................................................................... 135
Mergers and Acquisitions ......................................................................................................................... 137
Awards for MicroRNA Tools ...................................................................................................................... 137
Chapter 10: Analysis of Market Opportunities .................................................. 140
Factors Affecting the MicroRNA Market ................................................................................................... 141
Drivers of the MicroRNA Tools Market ................................................................................................. 141
Current Challenges for the MicroRNA Tools Market ............................................................................ 142
Chapter 11: Company Profiles ........................................................................... 144
Appendix: Abbreviations .................................................................................... 169
About BCC Research ......................................................................................... 172
About BCC Research.................................................................................................................................. 173
BCC Membership ...................................................................................................................................... 173
BCC Custom Research ............................................................................................................................... 173

List of Table

List of Tables
Summary Table Global Market for MicroRNA Tools, by Region, Through 2021 ($ Millions) ..................... 11
Table 1 Deoxy Ribose Nucleic Acid Vs Ribose Nucleic Acid ........................................................................ 16
Table 2 History of MicroRNA....................................................................................................................... 19
Table 3 MicroRNA Associated with Human Diseases ................................................................................. 21
Table 4 Expression Profile of MicroRNA in Different Types of Cancers ...................................................... 24
Table 5 Disease Classes Addressed by MicroRNA Therapeutics ................................................................. 26
Table 6 Selected Companies Developing MicroRNA Therapeutics ............................................................. 29
Table 7 Comparison of Various MicroRNA Detection Methods ................................................................. 31
Table 8 Selected Companies Offering MicroRNA Profiling Services ........................................................... 32
Table 9 Global Market for MicroRNA Tools, by Type, Through 2021 ($ Millions) ...................................... 45
Table 10 Global Market Share of MicroRNA Tools, by Type, 2015 (%) ...................................................... 46
Table 11 Global Market for Bioinformatics Tools in MicroRNA, by Region, Through 2021 ($ Millions) .... 48
Table 12 Global Market Share of Bioinformatics Tools in MicroRNA, by Region, 2015 (%) ....................... 49
Table 13 Global Market for MicroRNA Tools, by End User, Through 2021 ($ Millions) ............................ 55
Table 14 Global Market Share of MicroRNA Tools, by End User, 2015 (%) ................................................ 56
Table 15 Global Market for MicroRNA Tools Used for Research, by Type, Through 2021 ($ Millions) ...... 58
Table 16 Global Market for MicroRNA Tools Used for Therapeutics, by Type, Through 2021 ($ Millions) .................................................................................................................................................................... 61
Table 17 Global Market for MicroRNA Tools Used by the Service Sector, by Type, Through 2021 ($ Millions) ...................................................................................................................................................... 64
Table 18 Global Market for MicroRNA Tools Used for Diagnostics, by Type, Through 2021 ($ Millions) .. 67
Table 19 Global Market for MicroRNA Tools, by Application, Through 2021 ($ Millions) ........................ 72
Table 20 Global Market Share of MicroRNA Tools, by Application, 2015 (%) ............................................ 73
Table 21 Global Market for MicroRNA Tools Used for Cancer Diseases, by Type, Through 2021 ($ Millions) ...................................................................................................................................................... 76
Table 22 Global Market for MicroRNA Tools Used for Cardiovascular Diseases, by Type, Through 2021 ($ Millions) ...................................................................................................................................................... 79
Table 23 Global Market for MicroRNA Tools Used for Immunological Diseases, by Type, Through 2021 ($ Millions) ...................................................................................................................................................... 81
Table 24 Global Market for MicroRNA Tools Used for Neurological Diseases, by Type, Through 2021 ($ Millions) ...................................................................................................................................................... 83
Table 25 Global Market for MicroRNA Tools Used for Metabolic Disorders, by Type, Through 2021 ($ Millions) ...................................................................................................................................................... 86
Table 26 Global Market for MicroRNA Tools Used for Other Applications, by Type, Through 2021 ($ Millions) ...................................................................................................................................................... 88
Table 27 Global Market for MicroRNA Tools, by Region, Through 2021 ($ Millions) ................................. 93
Table 28 Global Market Share of MicroRNA Tools, By Region, 2015 (%) .................................................. 94
Table 29 Global Market for MicroRNA Microarray, by Region, Through 2021 ($ Millions) ....................... 97
Table 30 Global Market for Quantitative Reverse Transcription PCR, by Region, Through 2021 ($ Millions) ...................................................................................................................................................... 99
Table 31 Global Market for Next-Generation Sequencing, by Region, Through 2021 ($ Millions) ........ 102
Table 32 Global Market for Isolation, Purification and Detection Tools, by Region, Through 2021 ($ Millions) .................................................................................................................................................... 104
Table 33 Global Market for Fluorescence in Situ Hybridization, by Region, Through 2021 ($ Millions) . 106
Table 34 Global Market for Other Tools, by Region, Through 2021 ($ Millions) ...................................... 109
Table 35 Leading Manufacturers and Suppliers of MicroRNA Microarray, 2015 ..................................... 111
Table 36 Global Market Share of Manufacturers and Suppliers for MicroRNA Microarray, 2015 (%) .... 112
Table 37 Leading Manufacturers and Suppliers of Quantitative Reverse Transcription PCR, 2015 ........ 114
Table 38 Global Market Share of Manufacturers and Suppliers for Quantitative Reverse Transcription PCR, 2015 (%) ............................................................................................................................................ 115
Table 39 Leading Manufacturers and Suppliers of NextGeneration Sequencing, 2015 ......................... 116
Table 40 Global Market Share of Manufacturers and Suppliers for NextGeneration Sequencing, 2015 (%) ............................................................................................................................................................. 117
Table 41 Leading Manufacturers and Suppliers of Isolation, Purification and Detection Tools, 2015 .... 118
Table 42 Global Market Share of Manufacturers and Suppliers for Isolation, Purification and Detection Tools, 2015 (%) .......................................................................................................................................... 119
Table 43 Leading Manufacturers and Suppliers of MicroRNA Fluorescence In Situ Hybridization, 2015 121
Table 44 Global Market Share of Manufacturers and Suppliers for FISH, 2015 (%) ................................. 121
Table 45 Leading Manufacturers and Suppliers of Other Tools, 2015 ..................................................... 122
Table 46 Global Market Share of Manufacturers and Suppliers for Other Tools, 2015 (%) ..................... 123
Table 47 Number of Patents, by Year, 2014February 2017 .................................................................... 126
Table 48 Number of Patents, by Type, 2014February 2017 .................................................................. 127
Table 49 Number of Patents, by Company, 2014February 2017 ............................................................ 128
Table 50 Number of Patents, by Country, 2014-February 2017 ............................................................... 129
Table 51 Patent Shares, by Country, 2014February 2017 (%) ................................................................ 130
Table 52 Number of Patents, by Assignee, 2014February 2017 ............................................................. 132
Table 53 New Developments for MicroRNA Tools, 2014February 2017 ................................................ 133
Table 54 MicroRNA in the Research Pipeline as of February 2017 .......................................................... 136
Table 55 Mergers and Acquisitions of MicroRNA Tools Companies, 2014February 2017 .................... 137
Table 56 Awards for MicroRNA Tools Products, 2014February 2017 .................................................... 138
Table 57 Abbreviations Used in (MicroRNA Tools Report) ....................................................................... 169

List of Chart

List of Figures
Summary Figure Global Market for MicroRNA Tools, by Region, 20142021 ($ Millions)........................ 11
Figure 1 Global Market for MicroRNA Tools, by Type, 20142021 ($ Millions) ......................................... 45
Figure 2 Global Market Share of microRNA Tools, by Type, 2015 (%) ....................................................... 46
Figure 3 Global Market for Bioinformatics Tools in MicroRNA, by Region, 20142021 ($ Millions) ......... 49
Figure 4 Global Market Share of Bioinformatics Tools in MicroRNA, by Region, 2015 (%) ....................... 50
Figure 5 Global Market for MicroRNA Tools, by End User, 2014-2021 ($ Millions) ................................. 55
Figure 6 Global Market Share of MicroRNA Tools, by End User, 2015 (%) ................................................. 56
Figure 7 Global Market for MicroRNA Tools Used for Research, by Type, 20142021 ($ Millions) ........... 59
Figure 8 Global Market for MicroRNA Tools Used for Therapeutics, by Type, 20142021 ($ Millions) .... 62
Figure 9 Global Market for MicroRNA Tools Used by the Service Sector, by Type, 20142021 ($ Millions) .................................................................................................................................................................... 65
Figure 10 Global Market for MicroRNA Tools Used for Diagnostics, by Type, 2014-2021 ($ Millions) ...... 68
Figure 11 Global Market for MicroRNA Tools, by Application, 20142021 ($ Millions) ............................. 73
Figure 12 Global Market Share of MicroRNA Tools, by Application, 2015 (%) ........................................... 74
Figure 13 Global Market for MicroRNA Tools Used for Cancer Diseases, by Type, 20142021 ($ Millions) .................................................................................................................................................................... 77
Figure 14 Global Market for MicroRNA Tools Used for Cardiovascular Diseases, by Type, 20142021 ($ Millions) ...................................................................................................................................................... 79
Figure 15 Global Market for MicroRNA Tools Used for Immunological Diseases, by Type, 20142021 ($ Millions) ...................................................................................................................................................... 82
Figure 16 Global Market for MicroRNA Tools Used for Neurological Diseases, by Type, 20142021 ($ Millions) ...................................................................................................................................................... 84
Figure 17 Global Market for MicroRNA Tools Used for Metabolic Disorders, by Type, 2014 2021 ($ Millions) ...................................................................................................................................................... 86
Figure 18 Global Market for MicroRNA Tools Used for Other Applications, by Type, 20142021 ($ Millions) ...................................................................................................................................................... 89
Figure 19 Global Market for MicroRNA Tools, by Region, 20142021 ($ Millions) ................................... 93
Figure 20 Global Market Share of MicroRNA Tools, By Region, 2015 (%) ................................................. 94
Figure 21 Global Market for MicroRNA Microarray, by Region, 20142021 ($ Millions)........................... 97
Figure 22 Global Market for Quantitative Reverse Transcription PCR, by Region, 20142021 ($ Millions) .................................................................................................................................................................. 100
Figure 23 Global Market for Next-Generation Sequencing, by Region, 20142021 ($ Millions) ............. 102
Figure 24 Global Market for Isolation, Purification and Detection Tools, by Region, 20142021 ($ Millions) .................................................................................................................................................... 104
Figure 25 Global Market for Fluorescence in Situ Hybridization, by Region, 20142021 ($ Millions) .... 107
Figure 26 Global Market for Other Tools, by Region, 20142021 ($ Millions) ......................................... 109
Figure 27 Global Market Share of Manufacturers and Suppliers for MicroRNA Microarray, 2015 (%) .. 113
Figure 28 Global Market Share of Manufacturers and Suppliers for Quantitative Reverse Transcription PCR, 2015 (%) ............................................................................................................................................ 115
Figure 29 Global Market Share of Manufacturers and Suppliers for NextGeneration Sequencing, 2015 (%) ............................................................................................................................................................. 117
Figure 30 Global Market Share of Manufacturers and Suppliers for Isolation, Purification and Detection Tools, 2015 (%) .......................................................................................................................................... 120
Figure 31 Global Market Share of Manufacturers and Suppliers for FISH, 2015 (%) ............................... 122
Figure 32 Global Market Share of Manufacturers and Suppliers for Other Tools, 2015 (%) .................... 123
Figure 33 Number of Patents, by Year, 2014February 2017 .................................................................. 126
Figure 34 Number of Patents, by Type, 2014February 2017 .................................................................. 127
Figure 35 Number of Patents, by Country, 2014February 2017 ............................................................. 130
Figure 36 Patent Shares, by Country, 2014February 2017 (%) .............................................................. 131
Figure 37 Number of Patents, by Assignee, 2014February 2017 ........................................................... 132

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