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Macitentan (ACT-064992) - Analysis and Forecasts from 2013 to 2020

Published By :

GlobalData

Published Date : Jul 2011

Category :

Therapeutic Area

No. of Pages : 35 Pages



GlobalDatas pharmaceuticals report, Macitentan (ACT-064992) Analysis and Forecasts from 2013 to 2020 provides Macitentan sales estimates for US, EU5 and Japan. In addition, it covers detailed clinical assessment of the drug, factors impacting drug sales, competitive landscape, and analysis of sales performance during the forecast period (2013-2020). The report also includes information on Pulmonary Arterial Hypertension market. This report is built using data and information sourced from GlobalDatas proprietary databases, primary and secondary research using Companys corporate website, SEC filings, investor presentations and featured press releases, both from company and industry-specific third party sources, put together with in-house analysis, by GlobalData's team of industry experts. 

Scope
  • Therapy area profile including patient population for the US, EU5 and Japan (seven major markets)
  • Analysis and review of Macitentan including sales data
  • Qualitative and quantitative assessment of market space
  • Analysis of the trends, drivers and restraints shaping and defining the markets
  • In-depth analysis of Macitentan including efficacy, safety, pricing, competition and other details which influence its sales potential
  • Detailed sales forecast for 2013-2020 for Macitentan in the seven major markets
Reasons to buy
  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of competition by understanding the changing competitive landscape
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of the drugs performance 
  • Examine the historical sales performance of a drug in seven major markets
  • Obtain sales forecast for currently marketed/pipeline drug for 2011-2020 for all seven major markets
Table of Content

1 Table of Contents
1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 3

2 Introduction 4
2.1 Pulmonary Arterial Hypertension 4
2.2 Epidemiology 4
2.2.1 Prevalence 4
2.2.2 Mortality 5
2.3 Etiology 5
2.3.1 Scleroderma 5
2.3.2 Sickle Cell Disease 5
2.3.3 HIV/AIDS 5
2.3.4 Drug Abuse and Toxins 5
2.4 Economic Impact of PAH 5
2.5 GlobalData Report Guidance 6

3 Pulmonary Arterial Hypertension (PAH): Market Characterization 7
3.1 PAH Market 7
3.2 PAH Market Forecasts and CAGR 8
3.3 PAH Market : Drivers and Restraints 8
3.3.1 Drivers 9
3.3.2 Barriers 10

4 Classification of PAH 11
4.1 Classification Based on Cause and Clinical Presentation 11
4.1.1 Idiopathic PAH 11
4.1.2 Familial PAH 11
4.1.3 Drug Induced PAH 11
4.1.4 PAH Associated with Other Conditions 11
4.1.5 PAH Associated with Significant Venous or Capillary Involvement 11
4.2 Symptomatic Profile of PAH 11

5 Evolution of PAH Treatments 12

6 Medications 13
6.1 Prostanoids 13
6.1.1 Epoprostenol 13
6.1.2 Treprostinil 13
6.1.3 Iloprost 13
6.1.4 Beraprost 13
6.2 Endothelin Receptor Antagonists 13
6.2.1 Bosentan 13
6.2.2 Ambrisentan 14
6.2.3 Sitaxsentan 14
6.3 Phosphodiesterase Type 5 Inhibitors 14
6.3.1 Sildenafil 14
6.3.2 Tadalafil 14
6.4 Surgical Treatments 14
6.5 Investigational Combination Regimens 15
6.6 New Targets for PAH Therapy 15

7 Market Share by Class in PAH 17

8 Macitentan (ACT-064992) 18
8.1 Introduction 18
8.2 Mechanism of Action 18
8.3 Clinical Studies 18
8.4 Factors Affecting Sales of Macitentan 18
8.4.1 No Interaction with Chloramphenicol (CYP 3A4) Inhibitors 18
8.4.2 Low Adverse Effects 18
8.4.3 Mechanism of Action 19
8.5 Intensity of Competition 19
8.6 Sales Forecasts 19
8.6.1 Target Patient Pool of Macitentan 19
8.6.2 Dosing 20
8.6.3 Market Penetration 20
8.6.4 Annual Cost of Therapy 20
8.6.5 Sales Projections of Macitentan 21

9 PAH Market: Appendix 30
9.1 Market Definitions 30
9.2 List of Abberiviations 30
9.3 Research Methodology 31
9.3.1 Coverage 31
9.3.2 Secondary Research 31
9.3.3 Forecasting 31
9.3.4 Number of Patients Approved to take the Drug 32
9.3.5 Net Penetration of Drug 32
9.3.6 Net Annual Dosing 33
9.3.7 Annual Cost of Therapy 33
9.3.8 Primary Research 33
9.3.9 Expert Panels 33
9.4 Drug Sales Estimates Model 33
9.5 Contact Us 34
9.6 Disclaimer 34
9.7 Sources 34

List of Table


Table 1: PAH, Global, Major Marketed Drugs 7
Table 2: PAH, Global, Pipeline (Phase III) 8
Table 3: PAH Drugs Evolution 12
Table 4: Macitentan, PAH, Global, Sales Forecasts ($m), 20132020 21
Table 5: Macitentan, PAH, The US, Sales Forecasts ($m), 20132020 22
Table 6: Macitentan, PAH, The UK, Sales Forecasts ($m), 20132020 23
Table 7: Macitentan, PAH, France, Sales Forecasts ($m), 20132020 24
Table 8: Macitentan, PAH, Germany, Sales Forecasts ($m), 20132020 25
Table 9: Macitentan, PAH, Italy, Sales Forecasts ($m), 20132020 26
Table 10: Macitentan, PAH, Spain, Sales Forecasts ($m), 20132020 27
Table 11: Macitentan, PAH, Japan, Sales Forecasts ($m), 20152020 28

List of Chart


Figure 1: PAH, Global, Market Size Forecasts ($bn), 20102020 8
Figure 2: PAH, Worldwide, Market Share by Class (%), 2010 17
Figure 3: Drug Model Diagram of Macitentan 20
Figure 4: Macitentan, PAH, Global, Sales Forecasts ($m), 20132020 21
Figure 5: Macitentan, PAH, The US, Sales Forecasts ($m), 20132020 22
Figure 6: Macitentan, PAH, The UK, Sales Forecasts ($m), 20132020 23
Figure 7: Macitentan, PAH, France, Sales Forecasts ($m), 20132020 24
Figure 8: Macitentan, PAH, Germany, Sales Forecasts ($m), 20132020 25
Figure 9: Macitentan, PAH, Italy, Sales Forecasts ($m), 20132020 26
Figure 10: Macitentan, PAH, Spain, Sales Forecasts ($m), 20132020 27
Figure 11: Macitentan, PAH, Japan, Sales Forecasts ($m), 20152020 28
Figure 12: Macitentan, PAH, Global, Sales Distribution by Country (%), 2020 29
Figure 13: Drug Model Diagram 32
Figure 14: Patients Approved for the Drug 33

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