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Liquid Biopsy Research Tools, Services and Diagnostics: Global Markets

Published By :

BCC Research

Published Date : Sep 2017

Category :

Biotechnology

No. of Pages : 282 Pages

Report Highlights
The global liquid biopsy market should reach $4.5 billion by 2022 from $1.5 billion in 2017 at a compound annual growth rate (CAGR) of 24.2%, from 2017 to 2022.

Report Includes:
An overview of the global markets for liquid biopsy research tools, services, and diagnostics
Analyses of global market trends, with data from 2015 and 2016, estimates for 2017, and projections of compound annual growth rates (CAGRs) through 2022
Coverage of how these technologies can reduce invasive tumor biopsies, drive early cancer detection, and support precise drug administration
Detailed analysis of liquid biopsy workflow technologies, biomarker classes, sample types, and research tools reagents
Breakdowns of the market by product, product type, application, end use industry, technology, and indication
Evaluation of the market's dynamics, specifically growth drivers, restraints, and opportunities
Profiles of major players in the industry
Report Scope
The scope of the report includes liquid biopsy technologies, applications, industry subsegments, biomarker technologies, major funding initiatives, patents and companies.The market sizes for liquid biopsy diagnostics are given for the years 2015, 2016, 2017 (estimated) and 2022 (forecasted).

This report reviews liquid biopsy biomarkers and technologies and provides background on why liquid biopsy is increasingly viewed as a replacement for, or a companion to, tissue biopsy.It then discusses several of the significant large-scale research initiatives that are contributing to liquid biopsy development.Market driving forces are also discussed.

The structure of several important industry subsectors is reviewed, as well as major industry acquisitions and strategic alliances from January 2016 through July 2017.Industry subsectors analyzed includenext-generation sequencing(NGS) instruments, droplet digital PCR, target enrichment and amplification, single-cell DNA polymerase, prenatal screening, liquid biopsy, direct to consumer, and clinical laboratory.

The market for liquid biopsy diagnostics is analyzed in depth.The market is analyzed by application (cancer, reproductive health, transplant), biomarker type (nucleic acids, cells, extracellular vesicles, proteins), analysis platform (microarray, NGS, PCR, proteomics and other), analysis purpose (screening/early detection, diagnosis, therapy guidance, monitoring) and geography (North America, Europe, Asia-Pacific, Rest of World).

Market data cover the years 2015, 2016, 2017 (estimated) and 2022 (forecasted).

More than 165 companies in the liquid biopsy industry are profiled in this report.

BCC Research provides a summary of the main industry acquisitions and strategic alliances from January 2016 through July 2017, including key alliance trends.

Table of Contents
Chapter 1: Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
Related BCC Research Reports
Chapter 2: Summary and Highlights
Chapter 3: Overview
Introduction
Report Scope
Liquid Biopsy versus Traditional Biopsy
Markets
Growth Driving Forces
Key Trends
Industry
Chapter 4: Technology Background
Liquid Biopsy Biomarkers
Cancer Genomics
Noninvasive Prenatal Testing
Circulating Tumor Cell Technologies
CTC Workflow
Cell Isolation Technologies
CTC Sample Preparation Technologies
CTC Downstream Analysis Technologies
Comparison of Liquid Biopsy with Conventional Biopsy
Cancer Testing
Prenatal Testing
Chapter 5: Liquid Biopsy Initiatives
Blood Profiling Atlas
Cambridge Single Cell Analysis Core Facility
Cancer-ID
CTCTrap Consortium
Early Cancer Detection Consortium
Hematologic Oncology Consortium
National Center for Single-Cell Biology
Precancer Genome Atlas
Precision Medicine Initiative
Single Cell Analysis Program
TopMed
Worldwide Innovative Networking (WIN) Consortium
Chapter 6: Liquid Biopsy Applications
Introduction
Cancer Applications
Precision Medicine
Cancer Biomarker Status
Cancer Market Segments
Reproductive Health Applications
Transplant Diagnostics Applications
Chapter 7: Liquid Biopsy Industry
Introduction
NGS Instrument Industry
Third-Generation Sequencing Industry
Droplet Digital PCR Industry
Target Enrichment and Amplification Industry
Single-Cell DNA Polymerase Industry
NGS Clinical Informatics Industry
Testing Services Industry
Noninvasive Prenatal Testing Industry
Fetal Cell NIPT Industry
CTC Capture and Detection Industry
Liquid Biopsy Industry
Direct-to-Consumer Genetic Testing Industry
Chapter 8: Acquisitions and Strategic Alliances
Acquisitions
Strategic Alliances
Trends
2016 Alliances
2017 Alliances
Chapter 9: Liquid Biopsy Markets
Growth Driving Forces
Liquid Biopsy Market by Indication
Liquid Biopsy Market by Biomarker Type
Liquid Biopsy Market by Analysis Platform
Liquid Biopsy Market by Analysis Purpose
Noninvasive Prenatal Testing Market
Cancer Markets
Cancer Market by Indication
Cancer Market by Analysis Purpose
Cancer Market by Biomarker Class
Cancer Market by Analysis Method
Breast Cancer Market
Colorectal Cancer Market
Hematological Cancer Market
Lung Cancer Market
Pan-Cancer Market
Transplant Markets
Geographical Market
Chapter 10: Patent Review
Circulating Tumor Cell Patents
Cell-Free DNA Patents
Liquid Biopsy- and Sequencing-Related Patent Issues
Chapter 11: Company Profiles
About BCC Research
About BCC Research
BCC Membership
BCC Custom Research

List of Table

List of Tables
Summary Table: Global Liquid Biopsy Market, by Disease Class, Through 2022 ($ Millions)
Table 1: Liquid Biopsy Sample Types
Table 2: Liquid Biopsy Report Scope
Table 3: Global Liquid Biopsy Market, by Analysis Type, Through 2022 ($ Millions)
Table 4: Growth Driving Forces
Table 5: Key Trends in Liquid Biopsy Market
Table 6: Liquid Biopsy Industry Subsectors
Table 7: Liquid Biopsy Biomarker Classes
Table 8: Single-Cell Analysis to Identify Cancer Driver Mutations
Table 9: Genomics-Based Oncology Workflow
Table 10: Unique Challenges of CTC Capture and Analysis
Table 11: CTC Workflow
Table 12: Cell Differentiators
Table 13: Cell Isolation Technologies
Table 14: CTC Sample Preparation Technologies
Table 15: Single-Cell Analysis Technologies
Table 16: Estimated Annual Solid Biopsy Procedures Performed in the U.S. for Selected Cancers
Table 17: Main Risks for Needle-Based Tissue Biopsies
Table 18: Factors in Tissue Biopsy
Table 19: Prenatal Invasive Testing Technologies
Table 20: Invasive versus Noninvasive Prenatal Technologies
Table 21: Key Liquid Biopsy Research and Development Programs
Table 22: Source of Foreign Biomarkers for Liquid Biopsy Applications
Table 23: Personalized Medicine Driven by Cancer Common Genetic Mutations
Table 24: Cancer Liquid Biopsy Biomarker Clinical Status
Table 25: Cancer Liquid Biopsy Market Segments
Table 26: Reproductive Health Screening Application
Table 27: Ethical Issues Associated with NIPT
Table 28: Transplant Diagnostics Application
Table 29: Key Segments within the Liquid Biopsy Industry
Table 30: Next-Generation Sequencing Instrument Companies
Table 31: 3GS Industry, by Tier Status
Table 32: Advantages of Droplet Digital PCR for Single-Cell Analysis
Table 33: Droplet Digital PCR Industry
Table 34: Target Enrichment Industry
Table 35: Single-Cell DNA Polymerase Industry
Table 36: Next-Generation Sequencing Clinical Informatics Company Positioning
Table 37: Selected NGS Clinical Testing Laboratories
Table 38: NIPT Industry
Table 39: Global Market Share for NIPT, by Company and by Region, 2017
Table 40: German NGS-based Noninvasive Prenatal Diagnostic Companies, 2017
Table 41: NIPT Test Licensing, by Country
Table 42: Fetal Cell NIPT Industry
Table 43: CTC Capture and Detection Industry
Table 44: Liquid Biopsy Industry Company Focus
Table 45: Example of NGS-based Liquid Biopsy Market Differentiation
Table 46: Key Competitors in the Direct-to-Consumer Genetic Testing Industry
Table 47: Liquid Biopsy Industry Acquisitions, January 2016-July 2017
Table 48: Liquid Biopsy Strategic Alliances, January 2016-July 2017
Table 49: Liquid Biopsy Key Growth Driving Forces
Table 50: Global Liquid Biopsy Market, by Indication, Through 2022 ($ Millions)
Table 51: Global Liquid Biopsy Market, by Biomarker Type, Through 2022 ($ Millions)
Table 52: Global Liquid Biopsy Market, by Analysis Platform, Through 2022 ($ Millions)
Table 53: Global Liquid Biopsy Market, by Analysis Purpose, Through 2022 ($ Millions)
Table 54: Global NIPT Market, by Analysis Purpose, Through 2022 ($ Millions)
Table 55: Global NIPT Market, by Risk Type, Through 2022 ($ Millions)
Table 56: Global NIPT Market, by Biomarker Class, Through 2022 ($ Millions)
Table 57: Global NIPT Market, by Analysis Method, Through 2022 ($ Millions)
Table 58: Limitations of Solid Biopsy in Cancer Applications
Table 59: Global Cancer Market, by Indication, Through 2022 ($ Millions)
Table 60: Five-Year Survival Rate for Ovarian Cancer (%)
Table 61: Prostate Cancer Testing Industry
Table 62: Molecular Thyroid Nodule Classifier Test Company Positioning
Table 63: Global Cancer Market, by Analysis Purpose, Through 2022 ($ Millions)
Table 64: Cancer Detection Methods
Table 65: Early Detection Tissue of Origin Approaches
Table 66: NGS Instrument Company Companion Diagnostics Status
Table 67: Global Cancer Market, by Biomarker Class, Through 2022 ($ Millions)
Table 68: Global Cancer Market, by Analysis Method, Through 2022 ($ Millions)
Table 69: Global Breast Cancer Market, by Analysis Method, Through 2022 ($ Millions)
Table 70: Global Colorectal Cancer Market, by Analysis Method, Through 2022 ($ Millions)
Table 71: Global Hematological Cancer Market, by Analysis Method, Through 2022 ($ Millions)
Table 72: Global Lung Cancer Market, by Analysis Method, Through 2022 ($ Millions)
Table 73: Global Pan-Cancer Market, by Analysis Method, Through 2022 ($ Millions)
Table 74: Global Liquid Biopsy Transplant Market, by Analysis Purpose, Through 2022 ($ Millions)
Table 75: Global Liquid Biopsy Transplant Market, by Organ Type, Through 2022 ($ Millions)
Table 76: Transplant Procedures Performed in the U.S., 2015 and 2016
Table 77: Global Liquid Biopsy Transplant Market, by Analysis Method, Through 2022 ($ Millions)
Table 78: Global Liquid Biopsy Transplant Market, by Biomarker Class, Through 2022 ($ Millions)
Table 79: Global Liquid Biopsy Market, by Region, Through 2022 ($ Millions)
Table 80: Global Cancer Liquid Biopsy Market, by Region, Through 2022 ($ Millions)
Table 81: Global NIPT Market, by Region, Through 2022 ($ Millions)
Table 82: Global Transplant Market, by Region, Through 2022 ($ Millions)
Table 83: CTC-Related Patents, by Region, 2007-2017
Table 84: Cell-Free DNA-Related Patents, by Region, 2007-2017
Table 85: Status of Liquid Biopsy and Sequencing-Related Patent Disputes
Table 86: Sensitivity to Detect Drug-resistant Mutations in Viruses (%)

List of Chart

List of Figures
Summary Figure: Global Liquid Biopsy Market, by Disease Class, 2015-2022 ($ Millions)
Figure 1: How Cancer Genomics Drives Liquid Biopsy

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