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High-Throughput Screening: Technologies and Global Markets

Published By :

BCC Research

Published Date : Jan 2019

Category :

Pharmaceutical

No. of Pages : 214 Pages

"Summary

High-throughput screening (HTS) is relatively new set of technologies that allows the assay of staggering number of potential biological modulators against a range of target classes. HTS is fast gaining acceptance in drug discovery processes, since it enables the industry to analyze substantially large numbers of compounds in relatively short time span. The process is made possible by the application of automation technologies, notably robotics, multi-platform plate readers and detectors, and advanced imaging. For long, HTS has been employed in biological and chemical sciences and by pharmaceutical companies in toxicity profiling and gaining better understanding of the affinity of biological structures. Constant drive toward the use of miniaturized systems alongside high-throughput screening technologies is bolstering the expansion of the market. The use of HTS in determining cytotoxicity of small molecules has helped market players garner promising chunks of revenues in recent years. Some of the notably emerging applications of HTS are in combinatorial chemistry, and in screening protein, peptide, and genomics libraries. The key objective of these applications is expediting drug discovery. 

The growing number of combinatorial chemical synthesis taking place in the pharmaceutical and biotech industries for discovering novel therapeutics for chronic diseases is a trend in the market. Post the marketing of new drugs, HTS helps in shedding more light on metabolic, pharmacokinetic, and toxicological data. The growing relevance of HTS in reducing the cost of drug development is boosting the growth prospects. The global HTS market has also seen new frontiers from the growing popularity of high-density micro reaction wells arrays in drug making activities. 

The global high-throughput screening (HTS) market is expected to reach REDACTED by 2023 at a CAGR of REDACTED during the forecast period. HTS was invented in 1951 by Dr. Gyula Takatsky; six rows of 12 wells in Lucite were machined to develop the first microtiter plate. Technology and approaches for HTS have advanced in the last few years. High-throughput screening is a modern technique used in drug development that can be applied in the biological and chemical sciences. The application of robots, detectors, sensors and software enables a variety of analyses of chemical and biological compounds. This analysis can be conducted in a short time, and the toxicity of biological structures and
characteristics of metabolic and pharmacokinetic processes can be determined.

HTS aims to lead discovery for both pharmaceutical and agrochemical applications. The primary goal for pharmaceutical companies is to restructure drug discovery programs to develop the highest -performing drugs. Companies are prioritizing innovation in HTS as a major strategy in an increasingly competitive environment. The latest developments in molecular biology, chemistry, pharmacology, laboratory automation, bioinformatics and computing enable the discovery of new and innovative drugs. Furthermore, HTS enables the determination of cytotoxicity, which leads to significant decreases in expenditures and reductions in the length of the study.

HTS has become a key tool for companies and research industries, due to its ability to test large numbers of compounds quickly and efficiently. There are also opportunities for companies that can identify and implement new technology effectively. Effective integration of compound supply, assay operation and data management are essential to achieve necessary productivity. HTS is an advanced technology initiative that can utilize the advantages of the latest advances in bioscience, biotechnology, engineering and information science. A rising number of drug targets for screening, the large numbers of reagents and assay kits used in HTS techniques and increasing pharmaceutical R&D are boosting the
market. Additionally, considerable investments by government and research institutes in drug discovery are other factors that will drive the HTS market in the future. High-throughput screening enables researchers to screen huge chemical libraries against a growing number of targets for lead discovery. Drug discovery is significantly relying on both HTS and uHTS screening capability, as well as the automation technology. Ultra-high-throughput screening is defined as screening more than 100,000 generated data points per day.

Laboratory automation has grown from a novel technology to being widely used in combination with HTS technology. Applications of laboratory automation include sample generation and preparation, genomics and proteomics for target finding and validation, robotic storage devices, automated multiple parallel synthesis stations, parallel liquid handling systems, workstations and fully integrated robots for primary biological screening. Technological advancement in automation will expand the number of hits and be beneficial in hit discovery, hit profiling, pharmacological testing, re-synthesis in gram quantities and in vivo profiling. Further, artificial intelligence has the ability to analyze large amounts of data generated during biological research. Artificial intelligence enables drug discovery for rare and neglected disease by utilizing HTS datasets and machine learning models in order to identify molecules for further testing. The machine learning models have already been used for identifying lead molecules for tuberculosis therapies."

"Report Scope:

The HTS market has significant potential due to the rising demand for drug discovery, DNA sequencing, toxicity studies and genomics applications. The capabilities and possibilities of market growth increase with new technologies and technological advancement. Emerging economies such as China, India, Latin American and Eastern Europe are considered lucrative regions that are creating opportunities and scope for the HTS market. Significant investments and funding are coming from government and private ventures, research institutes and universities to explore the potential of this market.

The scope of this study includes the current market for drug discovery, protein analysis, biological active compound screening and compound profiling. The report also includes regulations, recent developments, market projections, the competitive landscape and market share. An analysis of patents, clinical trials, innovations, opportunities and the latest trends are also discussed in the report. The report explains the key trends of HTS technologies and applications in regions around the world. It also discusses the market determinants that act as motivating and restraining factors and provides insights to stakeholders and potential entrants. The report will be a key decision-making tool for government organizations, researchers, private players, angel investors, potential entrants and so forth.

Report Includes:

- 60 data tables and 30 additional tables
- An industry analysis of technologies and global markets for the high-throughput screening (HTS) within the industry
- Analyses of global market trends with data from 2017 to 2018, and projections of compound annual growth rates (CAGRs) through 2023
- Characterization and quantification of the market potential for HTS by geographical regions, technology types, detection methods, components, application segments and end-use industries
- A look at the influence of government regulations, technological updates and the economic factors augmenting the growth of the market
- Relevant patent analysis within the global HTS market
- Company profiles of the major market players and their corporate profiles, including Agilent Technologies Inc., Bio-Rad Laboratories Inc., Danaher Corp., GE Healthcare, Nikon Instruments Inc., PerkinElmer Inc., Sysmex Corp. and Thermo Fisher Scientific Inc."

Table of Contents
Chapter 1 Introduction
Study Goals and Objectives
Intended Audience
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Market and Technology Background
Market Trends
North America Dominates the Market
Significant Growth in APAC
Major Opportunities for Software and Bioinformatics
Evolution of High-Throughput Screening
Miniaturization of Assays for High-Throughput Screening
Optimization of High-Throughput Screening
Traditional and Novel Targets for Lead Discovery
HTS Milestones Since Inception
Conclusion
Overview of Microscope and Imaging Technologies
Scanning Probe Microscopy
Scanning Electron Microscopy
Transmission Electron Microscopy
Artificial Intelligence and Automated Devices in HTS
Technological Advancements
Cytometers
Detectors and Sensors
Liquid Handling Instruments
Technological Trends
Label-Free Technology
Microplate Technologies
Automation and Miniaturization
Microfluidics
Market Dynamics
Market Drivers
Market Opportunities
Limitations and Challenges
Chapter 4 Market Breakdown by Detection Method
Spectroscopy
Fluorescence Spectroscopy
Total Internal Reflection Fluorescence (TIRF)
Nuclear Magnetic Resonance (NMR)
Fourier Transformed Infrared (FTIR)
Light Scattering
Mass Spectrometry (MS)
Imaging Mass Spectrometry
MALDI Mass Spectrometry
Secondary Ion Mass Spectrometer
Mass Spectrometry Instruments
Chromatography
Gas Chromatography
Thin-Layer Chromatography
Liquid Chromatography
Ion Exchange Chromatography
Affinity Chromatography
Reversed-Phase Chromatography
Hydrophobic Interaction Chromatography
Calorimetry
Isothermal Titration Calorimetry
Differential Scanning Calorimetry
X-ray Diffraction
Microscopy
Chapter 5 Market Breakdown by Component
Instruments/Platforms
Imaging Devices
Microplate Readers
Cytometers
Liquid Handling Instruments
Consumables: Reagents and Kits
Software and Analytics (Bioinformatics)
ProMass Deconvolution Software by Thermo Fisher Scientific
Services
ADME Screening
SiRNA Screening
Chapter 6 Market Breakdown by Technology
Cell-Based Assays
Lab-on-a-Chip
Ultra-High-Throughput Screening
Label-Free Technology
Chapter 7 Market Breakdown by End User
Pharmaceutical and Biotechnology Companies
Research and Government Institutes
Lab and Pathology Facilities
Contract Research Organizations
Chapter 8 Market Breakdown by Application
Drug Discovery
Biological Active Compound Screening
Genomics Application
DNA Sequencing
Protein Analysis
Microarray Screening
Toxicity Studies
Compound Profiling
Chapter 9 Market Breakdown by Region
North America
United States
Canada
Europe
United Kingdom
Germany
France
Spain
Italy
Rest of Europe
Asia-Pacific
India
Japan
China
Rest of APAC
Rest of the World
Middle East
Africa
Latin America
Chapter 10 Patent Analysis and New Developments
New Technologies
DNA-Encoded Libraries
High-Throughput Screening with CRISPR-Cas9 and RNAi
High-Throughput Screening Using Artificial Intelligence and Machine Learning
High-Throughput Screening in Academia for Biomedical Research
Advances in Zebrafish High-Throughput Screening Technologies
Evolution of Ultra-High-Throughput Screening
Patent Analysis
New Developments
New Product Development
Chapter 11 Analysis of Market Opportunities
Key Supplier and Manufacturer Positioning and Strategy
Key Market Players in the High-Throughput Screening Market
Albany Molecular Research Inc.
PerkinElmer Inc.
Bio-Rad Laboratories Inc.
Thermo Fisher Scientific Inc.
Analysis of Primary Strategies
Research and Development Activities
Chapter 12 Company Profiles
AGILENT TECHNOLOGIES INC.
ALBANY MOLECULAR RESEARCH INC.
AURELIA BIOSCIENCE LTD.
AXXAM SPA
BECTON, DICKINSON AND CO.
BIO-RAD LABORATORIES INC.
BIOTEK INSTRUMENTS INC.
CARL ZEISS AG
CELL SIGNALING TECHNOLOGY INC.
CHARLES RIVER LABORATORIES INC.
CORNING INC.
CREATIVE BIOLABS INC.
CURIOX BIOSYSTEMS PTE LTD.
CYTOO SA
DANAHER CORP.
DE NOVO SOFTWARE
EUROFINS DISCOVERX CORP.
EVOTEC AG
FLUXION BIOSCIENCES INC.
GE HEALTHCARE
GENEDATA AG
HUDSON ROBOTICS INC.
INSTRUMENT SYSTEMS GMBH
INTELLICYT CORP.
MILLIPORESIGMA
MOLECULAR DEVICES LLC
NEMAMETRIX INC.
NIKON INSTRUMENTS INC.
OLYMPUS CORP.
PERKINELMER INC.
PHENOVISTA BIOSCIENCES LLC
PLATYPUS TECHNOLOGIES
SYSMEX CORP.
TECAN GROUP LTD.
THERMO FISHER SCIENTIFIC INC.
TTP LABTECH LTD.
VALA SCIENCES INC.

List of Table

List of Tables
Summary Table : Global Market for High-Throughput Screening, by Region, Through 2023
Table 1 : Microscope Manufacturers Using HTS, 2018
Table 2 : Automated Microplate Handling Systems in High-Throughput Screening
Table 3 : R&D Spending of Major Pharmaceutical Companies, 2013
Table 4 : R&D Spending in Pharmaceuticals, by Select OECD Countries, 20112012
Table 5 : Uses of High-throughput Platforms for Investigating Stem Cell Microenvironments
Table 6 : Comparison of High-Throughput Screening Microscopes, 2018
Table 7 : Global Market for High-Throughput Screening, by Detection Method, Through 2023
Table 8 : Global Market for Spectroscopy, by Region, Through 2023
Table 9 : Microplate Reader Products of BMG Labtech, with Detection Method
Table 10 : Global Market for Mass Spectrometry, by Region, Through 2023
Table 11 : Global Market for Chromatography, by Region, Through 2023
Table 12 : Chromatographers Available in the Market
Table 13 : Typical Applications for Predictor 96-Well Plates
Table 14 : Gas Chromatography Instruments, by Shimadzu Corp. for High-Throughput Screening
Table 15 : High-Performance Liquid Chromatography Systems
Table 16 : Global Market for Calorimetry, by Region, Through 2023
Table 17 : DCS Products Example
Table 18 : Global Market for X-Ray Diffraction, by Region, Through 2023
Table 19 : Select Available Products
Table 20 : Global Market for Microscopy, by Region, Through 2023
Table 21 : Global Market for High-Throughput Screening, by Component, Through 2023
Table 22 : Global Market for Instruments/Platform, by Segment, Through 2023
Table 23 : Global Market for Instruments and Platforms, by Region, Through 2023
Table 24 : High-Throughput Screening Instruments
Table 25 : Cytometers on the Market
Table 26 : Automated Liquid Handling Modules on the Market
Table 27 : Global Market for Consumables, by Region, Through 2023
Table 28 : Global Market for Software and Analytics, Through 2023
Table 29 : Global Market for High-Throughput Screening, by Region, Through 2023
Table 30 : Global Market for High-Throughput Screening, by Technology, Through 2023
Table 31 : Global Market for Cell-Based Assays, by Region, Through 2023
Table 32 : Types of Cell-Based Assays Used in High-Throughput Screening for Drug Discovery
Table 33 : Examples of Cell-Based Assays for High-Throughput Screening
Table 34 : Global Market for Lab-on-a-Chip, by Region, Through 2023
Table 35 : Global Market for Ultra-High-Throughput Screening, by Region, Through 2023
Table 36 : Global Market for Label-Free Technology, by Region, Through 2023
Table 37 : Label-Free Technology for High-Throughput Screening
Table 38 : Global Market for High-Throughput Screening, by End User, Through 2023
Table 39 : Global Market for Pharmaceutical and Biotechnology Company End Users of High-Throughput Screening, by Region, Through 2023
Table 40 : Global Market for Research and Government Institute End Users of High-Throughput Screening, by Region, Through 2023
Table 41 : Research Institutes with High-Throughput Screening Facilities
Table 42 : Global Market for Lab and Pathology Facility End Users of High-Throughput Screening, by Region, Through 2023
Table 43 : Global Market for Contract Research Organization End Users of High-Throughput Screening, by Region, Through 2023
Table 44 : Global Market for High-Throughput Screening, by Application, Through 2023
Table 45 : Global Market for Drug Discovery Applications of High-Throughput Screening, by Region, Through 2023
Table 46 : Global Market for Biological Active Compound Screening Applications of High- Throughput Screening, by Region, Through 2023
Table 47 : Global Market for Genomics Applications of High-Throughput Screening, by Region, Through 2023
Table 48 : Global Market for DNA Sequencing Applications of High-Throughput Screening, by Region, Through 2023
Table 49 : Global Market for Protein Analysis Applications of High-Throughput Screening, by Region, Through 2023
Table 50 : Global Market for Microarray Applications of High-Throughput Screening, by Region, Through 2023
Table 51 : Global Market for the Application of High-Throughput Screening in Toxicity Studies, by Region, Through 2023
Table 52 : Global Market for Compound Profiling Applications of High-Throughput Screening, by Region, Through 2023
Table 53 : Global Market for High-Throughput Screening, by Region, Through 2023
Table 54 : North American Market for High-Throughput Screening, by Country, Through 2023
Table 55 : North American Market for High-Throughput Screening, by Technology, Through 2023
Table 56 : North American Market for High-Throughput Screening, by Component, Through 2023
Table 57 : North American Market for High-Throughput Screening, by End User, Through 2023
Table 58 : North American Market for High-Throughput Screening, by Application, Through 2023
Table 59 : North American Market for High-Throughput Screening, by Detection Method, Through 2023
Table 60 : Total Pharmaceutical Business R&D Expenditures, 20112015
Table 61 : European Market for High-Throughput Screening, by Country, Through 2023
Table 62 : European Market for High-Throughput Screening, by Technology, Through 2023
Table 63 : European Market for High-Throughput Screening, by Component, Through 2023
Table 64 : European Market for High-Throughput Screening, by End User, Through 2023
Table 65 : European Market for High-Throughput Screening, by Application, Through 2023
Table 66 : European Market for High-Throughput Screening, by Detection Method, Through 2023
Table 67 : Asia-Pacific Market for High-Throughput Screening, by Country, Through 2023
Table 68 : Asia-Pacific Market for High-Throughput Screening, by Technology, Through 2023
Table 69 : Asia-Pacific Market for High-Throughput Screening, by Component, Through 2023
Table 70 : Asia-Pacific Market for High-Throughput Screening, by End User, Through 2023
Table 71 : Asia-Pacific Market for High-Throughput Screening, by Application, Through 2023
Table 72 : Asia-Pacific Market for High-Throughput Screening, by Detection Method, Through 2023
Table 73 : Vaccine Manufacturers in India
Table 74 : Clinical Research Institutes in India
Table 75 : R&D Presence in China of Top 20 Pharmaceutical Companies
Table 76 : Academic Screening Facilities in China
Table 77 : RoW Market for High-Throughput Screening, by Technology, Through 2023
Table 78 : RoW Market for High-Throughput Screening, by End User, Through 2023
Table 79 : RoW Market for High-Throughput Screening, by Component, Through 2023
Table 80 : RoW Market for High-Throughput Screening, by Detection Method, Through 2023
Table 81 : RoW Market for High-Throughput Screening, by Application, Through 2023
Table 82 : Total Number of Patents in High-Throughput Screening, 20162018
Table 83 : Number of Patents on High-Throughput Screening, by Key Players, 20162017
Table 84 : U.S. Patents on High-Throughput Screening, January 2016 to July 2018
Table 85 : European Patents on High-Throughput Screening, January 2016 to July 2018
Table 86 : Japanese Patents on High-Throughput Screening, January 2016 to July 2018
Table 87 : Company Product Portfolios of High-Throughput Screening Systems
Table 88 : Albany Molecular Research Subsidiaries and Their Business Activities, 20152016
Table 89 : Innovations and Advancements in Existing Products of Thermo Fisher Scientific, 2018

List of Chart

List of Figures
Summary Figure : Global Market for High-Throughput Screening, by Region, 2017-2023
Figure 1 : High-Throughput Screening Well Specification
Figure 2 : Triangle of High-Throughput Screening
Figure 3 : First-Generation High-Throughput Screening, 19932000: Throughput
Figure 4 : Second-Generation High-Throughput Screening, 20012006: Efficiency
Figure 5 : Third-Generation High-Throughput Screening, 2007 Onward: Flexibility
Figure 6 : Alternative Approaches to Image Sample Surface
Figure 7 : Top 10 CRO Companies, by Revenue, 2017
Figure 8 : Global Pharmaceutical R&D Spending, 20092015
Figure 9 : Global Funding for Diseases, 20142016
Figure 10 : GDP Growth Rate of India and China, 20132016
Figure 11 : Components of Mass Spectrometer
Figure 12 : Advantages of MALDI-TOF instruments
Figure 13 : Advantages of Thin-Layer Chromatography
Figure 14 : Features of 1290 Infinity II High-Throughput System
Figure 15 : Advantages and Disadvantages of Ion Exchange Chromatography
Figure 16 : Research Challenges for High-Throughput Light Microscope Analysis of Cells and Tissue
Figure 17 : Features of ProMass Deconvolution Software
Figure 18 : Features of Trace Finder Software
Figure 19 : Process of uHTS System
Figure 20 : Key Pharmaceutical and Biotechnology Companies Providing High-Throughput Screening
Figure 21 : Drug Discovery Process Using High-Throughput Screening
Figure 22 : Benefits of High-Throughput Screening in Biological Active Compound Screening
Figure 23 : Types of Toxicity Studies
Figure 24 : Strategies to Improve Screening Using Compound Profiling
Figure 25 : Gross Domestic Spending on Healthcare R&D in North American Countries, 2016
Figure 26 : U.S. Healthcare Expenditures on R&D, by State, FY 2016
Figure 27 : Surveillance of Viral Hepatitis in the U.S., 2015
Figure 28 : Total Health Expenditure Shares in Canada, by Source of Funds, 2016
Figure 29 : Distribution of Causes of Mortality in Canada, 2017
Figure 30 : Horizon 2020 Funding, by Sector, 20142022
Figure 31 : European Healthcare Expenditures as a Share of GDP, by Sector, 2015
Figure 32 : European Healthcare Expenditures, as a Share of GDP, 2015
Figure 33 : Biotech Funding in the U.K., by Type of Source, 2017
Figure 34 : Investors in New and Existing Capital Expenditures, 2016
Figure 35 : Germanys Total Healthcare Spending, 20132016
Figure 36 : R&D Funding in Healthcare Research and the Healthcare Industry, 2016 and 2017
Figure 37 : Systems Used in High-Throughput Screening Platform at I-Stem
Figure 38 : Mortality from Cancer in Italy, 20112017
Figure 39 : European Countries with High Cancer Mortality, 2014
Figure 40 : Indian Healthcare Expenditures, 20042014
Figure 41 : Pharmaceutical R&D Expenditures in Japan, 19952015
Figure 42 : Chinas Healthcare Expenditures, by Sector, 2016
Figure 43 : Factors That Allow AMRI To Stay Competitive in The Market
Figure 44 : PerkinElmer Strategies
Figure 45 : Strategies Adopted by Key Market Players

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