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Diarrhea and Constipation Drug Development Pipeline Review, 2018

Published By :

GBI Research

Published Date : Jul 2018

Category :

Pharmaceutical

No. of Pages : 93 Pages

Diarrhea and Constipation Drug Development Pipeline Review, 2018

Summary

This report provides an overview of the pipeline landscape for diarrhea and constipation. It provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for diarrhea and constipation, and features dormant and discontinued products.

Diarrhea is a contagious gastrointestinal infection occurring mostly due to unhygienic conditions. Diarrhea may be related to a viral or bacterial infection and is sometimes the result of food poisoning. Symptoms include nausea, abdominal pain, cramping, bloating, dehydration, fever, bloody stools, frequent urge to evacuate the bowels and incontinence. There are 54 products in development for this indication and molecular targets present in the pipeline landscape include cystic fibrosis transmembrane conductance regulator and glucagon like peptide 2 receptor.

Constipation refers to the infrequent or difficult passing of stool. Constipation occurs when bowel movements become difficult or less frequent. Symptoms of constipation include swollen abdomen or abdominal pain, pain and vomiting.

The predisposing factors include eating disorders, irritable bowel syndrome, and hypothyroidism, overuse of laxatives (stool softeners) which, over time, weaken the bowel muscles, stress, inadequate water intake and inadequate fiber in the diet. There are 25 products in development for this indication and molecular targets present in the pipeline landscape include 5-hydroxytryptamine receptor 4 and heat stable enterotoxin receptor.

Companies operating in this pipeline space include Synthetic Biologics, Allergan and Ardelyx.

Scope

- Which companies are the most active within each pipeline?
- Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
- To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
- What are the most important R&D milestones and data publications to have happened in this disease area?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication and a comprehensive picture of recent updates and milestones for each
- Analyze the companies, institutions and universities currently operating in the pipeline and the products being fielded by each of these
- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration

1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 5
1.2 List of Figures 6
2 Introduction 7
2.1 Diarrhea and Constipation Report Coverage 7
2.2 Constipation - Overview 7
2.3 Diarrhea - Overview 7
3 Therapeutics Development 8
3.1 Constipation 8
3.2 Diarrhea 13
4 Therapeutics Assessment 20
4.1 Constipation 20
4.2 Diarrhea 26
5 Companies Involved in Therapeutics Development 33
5.1 Constipation 33
5.2 Diarrhea 41
6 Dormant Projects 57
6.1 Constipation 57
6.2 Diarrhea 58
7 Discontinued Products 61
7.1 Constipation 61
7.2 Diarrhea 61
8 Product Development Milestones 62
8.1 Constipation 62
8.2 Diarrhea 78
9 Appendix 92
9.1 Methodology 92
9.2 Coverage 92
9.3 Secondary Research 92
9.4 Primary Research 92
9.5 Expert Panel Validation 92
9.6 Contact Us 93
9.7 Disclaimer 93

1.1 List of Tables
Table 1: Number of Products under Development for Constipation 8
Table 2: Number of Products under Development by Companies, Constipation 10
Table 3: Number of Products under Development by Universities/Institutes, Constipation 11
Table 4: Products under Development by Companies, Constipation 12
Table 5: Products under Development by Universities/Institutes, Constipation 13
Table 6: Number of Products under Development for Diarrhea 13
Table 7: Number of Products under Development by Companies, Diarrhea 14
Table 8: Number of Products under Development by Universities/Institutes, Diarrhea 16
Table 9: Products under Development by Companies, Diarrhea 17
Table 10: Products under Development by Universities/Institutes, Diarrhea 19
Table 11: Number of Products by Stage and Target, Constipation 21
Table 12: Number of Products by Stage and Mechanism of Action, Constipation 22
Table 13: Number of Products by Stage and Route of Administration, Constipation 24
Table 14: Number of Products by Stage and Molecule Type, Constipation 25
Table 15: Number of Products by Stage and Target, Diarrhea 27
Table 16: Number of Products by Stage and Mechanism of Action, Diarrhea 29
Table 17: Number of Products by Stage and Route of Administration, Diarrhea 31
Table 18: Number of Products by Stage and Molecule Type, Diarrhea 32
Table 19: Constipation - Pipeline by Allergan Plc 33
Table 20: Constipation - Pipeline by Ardelyx Inc 33
Table 21: Constipation - Pipeline by Braintree Laboratories Inc 34
Table 22: Constipation - Pipeline by Dong-A ST Co Ltd 34
Table 23: Constipation - Pipeline by EA Pharma Co Ltd 35
Table 24: Constipation - Pipeline by Ironwood Pharmaceuticals Inc 35
Table 25: Constipation - Pipeline by Johnson & Johnson 36
Table 26: Constipation - Pipeline by MallInckrodt Plc 37
Table 27: Constipation - Pipeline by NGM Biopharmaceuticals Inc 37
Table 28: Constipation - Pipeline by RaQualia Pharma Inc 38
Table 29: Constipation - Pipeline by Sanwa Kagaku Kenkyusho Co Ltd 38
Table 30: Constipation - Pipeline by SK Biopharmaceuticals Co Ltd 38
Table 31: Constipation - Pipeline by Sumitomo Dainippon Pharma Co Ltd 39
Table 32: Constipation - Pipeline by Synthetic Biologics Inc 39
Table 33: Constipation - Pipeline by Vanda Pharmaceuticals Inc 40
Table 34: Constipation - Pipeline by Yuhan Corp 40
Table 35: Constipation - Pipeline by Zensun (Shanghai) Sci & Tech Co Ltd 41
Table 36: Diarrhea - Pipeline by Aegis Therapeutics LLC 41
Table 37: Diarrhea - Pipeline by Akthelia Pharmaceuticals Ltd 42
Table 38: Diarrhea - Pipeline by Albireo Pharma Inc 42
Table 39: Diarrhea - Pipeline by Allergan Plc 43
Table 40: Diarrhea - Pipeline by Ardelyx Inc 43
Table 41: Diarrhea - Pipeline by AzurRx BioPharma Inc 43
Table 42: Diarrhea - Pipeline by Bharat Biotech Ltd 44
Table 43: Diarrhea - Pipeline by Chongqing Zhifei Biological Products Co Ltd 44
Table 44: Diarrhea - Pipeline by Cosmo Pharmaceuticals NV 45
Table 45: Diarrhea - Pipeline by DiscoveryBiomed Inc 45
Table 46: Diarrhea - Pipeline by Ferring International Center SA 46
Table 47: Diarrhea - Pipeline by GP Pharm SA 46
Table 48: Diarrhea - Pipeline by Kuhnil Pharmaceutical Co Ltd 47
Table 49: Diarrhea - Pipeline by Metacrine Inc 47
Table 50: Diarrhea - Pipeline by Miyarisan Pharmaceutical Company Ltd 48
Table 51: Diarrhea - Pipeline by Napo Pharmaceuticals Inc 48
Table 52: Diarrhea - Pipeline by Nippon Shinyaku Co Ltd 49
Table 53: Diarrhea - Pipeline by Novartis AG 49
Table 54: Diarrhea - Pipeline by Pfizer Inc 50
Table 55: Diarrhea - Pipeline by Prokarium Ltd 50
Table 56: Diarrhea - Pipeline by Protagonist Therapeutics Inc 51
Table 57: Diarrhea - Pipeline by RaQualia Pharma Inc 51
Table 58: Diarrhea - Pipeline by RedHill Biopharma Ltd 52
Table 59: Diarrhea - Pipeline by RxBio Inc 52
Table 60: Diarrhea - Pipeline by Scandinavian Biopharma Holding AB 53

1.2 List of Figures
Figure 1: Number of Products under Development for Constipation 8
Figure 2: Number of Products under Development by Companies, Constipation 9
Figure 3: Number of Products under Development for Diarrhea 13
Figure 4: Number of Products under Development by Companies, Diarrhea 14
Figure 5: Number of Products under Development by Universities/Institutes, Diarrhea 16
Figure 6: Number of Products by Targets, Constipation 20
Figure 7: Number of Products by Stage and Targets, Constipation 20
Figure 8: Number of Products by Top 10 Mechanism of Actions, Constipation 21
Figure 9: Number of Products by Stage and Top 10 Mechanism of Actions, Constipation 22
Figure 10: Number of Products by Routes of Administration, Constipation 23
Figure 11: Number of Products by Stage and Routes of Administration, Constipation 23
Figure 12: Number of Products by Molecule Types, Constipation 24
Figure 13: Number of Products by Stage and Molecule Types, Constipation 25
Figure 14: Number of Products by Top 10 Targets, Diarrhea 26
Figure 15: Number of Products by Stage and Top 10 Targets, Diarrhea 26
Figure 16: Number of Products by Top 10 Mechanism of Actions, Diarrhea 28
Figure 17: Number of Products by Stage and Top 10 Mechanism of Actions, Diarrhea 28
Figure 18: Number of Products by Routes of Administration, Diarrhea 30
Figure 19: Number of Products by Stage and Routes of Administration, Diarrhea 30
Figure 20: Number of Products by Top 10 Molecule Types, Diarrhea 31
Figure 21: Number of Products by Stage and Top 10 Molecule Types, Diarrhea 32

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