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Cell-based Assays: Technologies and Global Markets

Published By :

BCC Research

Published Date : Jul 2017

Category :

Biotechnology

No. of Pages : 219 Pages

Report Highlights:
The global market for cell-based assays should grow from $20.1 billion in 2018 to $32.7 billion by 2023 at a compound annual growth rate (CAGR) of 10.2% from 2018 through 2023.

The global market for drug discovery for validating drug targets/lead profiling assays should grow from $14.4 billion in 2018 to $23.6 billion by 2023 at a CAGR of 10.4% from 2018 through 2023.

The global market for basic research for understanding cell signaling and function should grow from $2.0 billion in 2018 to $3.5 billion by 2023 at a CAGR of 12.1% from 2018 through 2023.

Report Scope:
This report is an update of an earlier report of the same title. It reviews global markets and new developments for cell-based assays and forecasts trends for the use of these assays for drug discovery, safety and toxicology through 2023. The report includes details of important assays, technologies and the latest developments and outlines market shares by assay type and company, with a special emphasis on the U.S. market. Statistical information on the prevalence of types of cancers worldwide is also included.

The report also details current issues and trends affecting the industry, as well as costs and factors that have an impact on demand. It covers products in development, new technologies, trends, and alliances and mergers. The report offers market data by segment and region and discusses market trends with respect to drivers, restraints and opportunities.

Report Includes:
23 data tables and 48 additional tables
Detailed overview of the global market for cell-based assays within the industry
Analyses of global market trends with data from 2017, estimates for 2018, and projections of compound annual growth rates (CAGRs) through 2023
Details of important assays, technologies and the latest developments and outlines market shares by assay type and company, with a special emphasis on the U.S. market
Regional dynamics of cell-based assays covering North America, Europe and other emerging economies
Examination of the cell-based assays available and currently being used, new developments, spending trends, and revenue prospects for cell-based assays in the pharmaceutical industry
Discussion of current issues and trends affecting the industry, as well as costs and factors that have an impact on demand
Coverage of major issues involved in the research and development (R&D) of more effective cell-based approaches for drug discovery
Company profiles of major players in the industry including Beckman Coulter, DiscoverX, PerkinElmer, Life Technologies and Promega Corp.

Chapter 1: Introduction .. 1
Study Goals and Objectives .. 1
Reasons for Doing This Study .. 1
Scope of Report .. 1
Intended Audience .. 2
Methodology .. 2
Geographic Breakdown .. 2
Analyst's Credentials .. 4
Related BCC Research Reports .. 4
Chapter 2: Summary and Highlights .. 6
Chapter 3: Overview .. 11
Introduction .. 11
Drug Discovery .. 11
High-content Screening .. 13
Data Analysis .. 14
Overview: Cell-based Assays .. 15
Tools for Drug Discovery .. 18
High-content Screening .. 20
Cell-based Screening .. 23
Proliferation Assays .. 25
Proof of Concept for Cell-based Assays .. 31
Cell-based Assays and Technology Trends .. 31
Chapter 4: Assays for Drug Discovery .. 46
Cell-based Approaches for ADME/Tox Screening .. 46
Market Opportunity .. 48
ADME and Toxicity Screening .. 51
Multiplexed Cell-based Assays .. 57
Cell-based Biological Assays .. 59
High-throughput Imaging-based Platform for Cell-based Assays .. 60
Cell Assays in Todays Drug Discovery Process .. 61
Label-free Cellular Assays: The Relevant Future of Drug Discovery .. 64
Conclusions .. 69
Chapter 5: Cell-based Assays: Current Technologies .. 71
Factors in Cell-based Assay Development .. 71
Reporter Gene Technology .. 74
Cell-based Assays for Studying ProteinProtein Interactions .. 76
Cell-based Protein-Fragment Complementation Assays .. 76
Measuring Calcium Signaling .. 77
Cell-based Label-free Approaches .. 77
Automation and Miniaturization .. 78
Cell Patterning .. 79
Cell-based Assays and Physiological Relevance .. 79
Cell-based Assays and Multiplexing .. 80
Developing Reporter Assays .. 80
Reporter Assays and Multiplexing .. 81
Ultra-high-throughput Screening .. 81
Development of PathHunter Assay .. 83
High-content Screening Technology .. 83
Imaging Cells for Cell-based Assays .. 85
Microscopic Visualization of Cells .. 85
Quantum Dots .. 86
Label-free Imaging .. 87
Investigational New Drug (IND) Studies in Drug Development .. 88
Role of ADME in Drug Design .. 90
Prodrug Strategies .. 91
Molecular Modeling .. 92
Summary .. 93
Limitations of Cell-based Assays in the Process of Risk Assessment .. 93
Bottlenecks in Cell-based Screening.. 94
Methods to Improve Throughput in Cell-based Assays .. 95
New Technologies .. 96
DataChip .. 97
BIND Technology .. 98
Miniaturization of Biological Assays .. 99
Microfluidic Cell Culture Systems for Drug Research .. 101
Conclusion .. 101
Chapter 6: Commercialization of Cell-based Assays .. 104
Role of Cell-based Assays .. 104
Drug Discovery and Cell-based Assays .. 104
Opportunities for Market Adoption .. 104
Measuring Cell Proliferation .. 107
Companies Offering Cell Proliferation Assays .. 107
Move Toward Therapies with Stem and Immune Cells .. 108
Cell-based Screening Assays .. 109
Orphan Receptors .. 115
Summary .. 117
Chapter 7: Global Cell-based Assay and Instrumentation Market .. 119
Current Market Overview .. 119
Cell-based Assays .. 119
Cell-based Assay Market .. 120
Market Dynamics .. 121
Market Drivers .. 122
Cell-based Assays for Preclinical Development .. 122
Cell Biology Reagents .. 123
High-throughput Screening .. 124
Advantages of HTS Assays .. 125
Major Drivers .. 125
Drug Discovery Technology Market .. 127
Market for Life Sciences Tools and Reagents .. 128
Cell Culture Market .. 130
Cell Culture Reagent Market .. 131
Global Market for Cell Culture Reagents .. 132
Three-dimensional Cell Culture Market .. 134
Cell-based Assays Market Growth .. 136
Market Demand .. 140
Cell-based Assays: Basic Research .. 141
Market for Cellular Assays in Basic Research .. 142
GE Healthcare and Products .. 143
Cell Proliferation Fluorescence Assay .. 143
In vitro Toxicity Testing .. 144
In vitro Skin Irritation Testing .. 146
ADME and Toxicology Market .. 147
In vitro Predictive Toxicology .. 148
Cell-based Assays for Drug Discovery .. 150
ADME-Toxicology Testing Market .. 152
DiscoverX .. 153
ADME: Tools and Technologies .. 154
ADME Studies for FDA Submissions .. 154
Market Players .. 155
New Developments .. 157
In vitro Inflammation Models .. 160
Multiplex Assays for GPCR Signaling .. 160
Types of Cell-based Assays .. 161
HCS Market Drivers .. 164
Molecular Devices .. 165
High-Content Screening Kits .. 168
High-content Screening Instrumentation Market .. 169
Flow Cytometers .. 171
Label-free Detection Market .. 172
Microplate Instrumentation and Supplies .. 172
Challenges with Cell-based Assays .. 172
Future of Cell-based Assays .. 173
Cell-based Assays for Research Purposes .. 174
G Protein-Coupled Receptors .. 174
Key Facts .. 183
Cell-based Assays: Screening Ion Channels .. 184
Label-free Detection .. 185
Companies .. 186
CellSensor Assays .. 187
LanthaScreen Assays .. 188
Molecular Devices .. 188
Conclusion .. 189
Chapter 8: Global Regional Markets .. 191
Global Market for Cell-based Assays .. 191
Cell-based Assays in the Leading Emerging Markets .. 192
Summary .. 192
U.S. Market .. 194
Global Market Overview .. 195
European Market .. 197
Drug Discovery in the Emerging Economies .. 199
Drug Discovery in India and China .. 199
Advances in Cell-based Assays .. 203
Contract Research Organizations and Cell-based Assays .. 204
Outlook .. 204
Chapter 9: Company Profiles .. 206
Chapter 10: Legal Aspects of Cell-based Assays .. 218
Intellectual Property Landscape for Cell-based Assays .. 218
Latest News, Alliances and Mergers .. 220
Label-free Technologies .. 223
Summary and Outlook .. 224
Appendix: Bibliography .. 226
About BCC Research .. 228
About BCC Research .. 229
BCC Membership .. 229
BCC Custom Research .. 229

List of Table

Summary Table: Global Market for Cell-based Assays, Through 2021 ($ Millions) .. 8
Table 1 Cell-Based Assays and Uses .. 13
Table 2 Types of Cell-based Assays .. 25
Table 3 Apoptotic Markers .. 26
Table 4 Proof-of-Concept for Cell-based Assays .. 31
Table 5 Global Market and Forecast for Cell-based Assays, Through 2021 ($ Millions) .. 34
Table 6 Biological Assay Systems for the Evaluation of Cytochrome P450 Enzyme Isoforms .. 52
Table 7 Hepatocyte Assay Systems .. 54
Table 8 ADME Assays .. 55
Table 9 Common Toxicity Assays .. 55
Table 10 Traditional Methods of ADME/Tox Testing .. 56
Table 11 Conventional in vitro ADME/Tox Screening Methods .. 56
Table 12 Label-free Assays and Applications .. 65
Table 13 Factors for Cell-based Assay Development .. 72
Table 14 Approaches to Cell-based Systems for Drug Screening .. 75
Table 15 Current Confocal HCS Platforms .. 84
Table 16 Widefield HCS Platforms .. 84
Table 17 Studies for Filing an IND .. 88
Table 18 Studies for Clinical Filings .. 89
Table 19 Existing Technologies .. 96
Table 20 Biological Applications for HCA .. 106
Table 21 Global Market for Cell Biology Reagents and Tools, Through 2021 ($ Millions) .. 123
Table 22 Global HTS Market, Through 2021 ($ Millions) .. 125
Table 23 HTS Technologies: Key Companies .. 126
Table 24 Global Market for Drug Discovery Technologies, Through 2021 ($ Millions) .. 127
Table 25 Key Companies for Drug Discovery Technologies .. 128
Table 26 Global Market for Reagents and Tools Used in Life Sciences Research, Through 2021 ($
Millions) .. 128
Table 27 Global Market for Cell Culture, Through 2021 ($ Millions) .. 130
Table 28 Global Cell Culture Reagent Types .. 131
Table 29 Global Market for Cell Culture Reagents, Through 2021 ($ Millions) .. 132
Table 30 U.S. Market for Cell Culture, Through 2021 ($ Millions) .. 134
Table 31 Global Market for 3D Cell Culture, Through 2019 ($ Millions) .. 135
Table 32 3D Cell Culture .. 136
Table 33 Cell-based Assay companies .. 137
Table 34 Cell-based Assay Market .. 138
Table 35 Global Market for Cell-Based Assays, Through 2021 ($ Millions) .. 139
Table 36 Limitations of Cell-Based Assays .. 140
Table 37 Global Market for Cell-based Assays Used in Basic Research, Through 2021 ($ Millions) .. 142
Table 38 In vitro Toxicology Testing .. 144
Table 39 Global 3D Cell Culture, Through 2021 ($ Millions) .. 149
Table 40 Global Market for Specialized Cell-based Assays used in Drug Discovery, Through 2021 ($
Millions) .. 150
Table 41 In vitro Predictive Toxicology Assays .. 151
Table 42 3D Microtissue and Spheroid Models .. 154
Table 43 Global Market for ADME Assays, Through 2021 ($ Millions) .. 156
Table 44 Key Companies .. 158
Table 45 HCS Market: Major Companies .. 164
Table 46 Molecular Devices: Products .. 166
Table 47 HCS System Platforms .. 167
Table 48 Millipore Products: Applications .. 169
Table 49 Global Market for High-content Screening Instruments, Through 2018 ($ Millions) .. 170
Table 50 Key Flow Cytometry Companies .. 171
Table 51 Key GPCR-targeting Drugs .. 175
Table 52 Key Companies .. 176
Table 53 Omeros: GPCRs and Indications .. 177
Table 54 Assay Methods to Study GPCRs .. 182
Table 55 GPCR Primary Screening Assays .. 182
Table 56 Thermo Fishers Products .. 186
Table 57 Thermo Fishers Cell-based Technologies .. 187
Table 58 Global Market for Cell-based Assays, by Region, Through 2021 ($ Millions) .. 193
Table 59 U.S. Market for Cell-based Assays, Through 2021 ($ Millions) .. 195
Table 60 Key Growth Drivers of the Market for Cell-based Assays .. 197
Table 61 European Market for Cell-based Assay, Through 2021 ($ Millions) .. 198
Table 62 Chinese Drug Discovery Outsourcing Market, Through 2021 ($ Millions) .. 200
Table 63 Indian Drug Discovery Market, Through 2021 ($ Millions) .. 201

List of Chart

Summary Figure: Global Market for Cell-based Assays, 2015-2021 ($ Millions) .. 8
Figure 1 Drug Discovery Process and Steps .. 12
Figure 2 Global Market and Forecast for Cell-based Assays, 20152021 ($ Millions) .. 34
Figure 3 Global Market for Cell Biology Reagents and Tools, 20122021 ($ Millions) 124
Figure 4 Global Market for Drug Discovery Technologies, 20132021 ($ Millions) .. 127
Figure 5 Global Market for Reagents and Tools used in Life Sciences Research, 2016 and 2021 ($
Millions) .. 129
Figure 6 Global Market for Cell Culture, 20132021 ($ Millions) .. 130
Figure 7 Global Market for Cell Culture Reagents, 20132021 ($ Millions) .. 133
Figure 8 U.S. Market for Cell Culture, 2013-2021 ($ Millions) .. 134
Figure 9 Global Market for 3D Cell Culture Reagents, 20132019 ($ Millions) .. 135
Figure 10 Global Market for Cell-Based Assays, 20132021 ($ Millions) .. 139
Figure 11 Global Market for Cell-based Assays Used in Basic Research, 20132021 ($ Millions) .. 143
Figure 12 Global 3D Cell Culture, 2016 and 2021 ($ Millions) .. 150
Figure 13 Global Market for Specialized Cell-based Assays used in Drug Discovery, 20132021 ($
Millions) .. 151
Figure 14 Global Market for ADME Assays, 20132021 ($ Millions) .. 156
Figure 15 Global Market for High-content Screening Instruments, 2013 and 2018 ($ Millions) .. 170
Figure 16 Global Market for Cell-Based Assays, by Region, 20132021 ($ Millions) .. 193
Figure 17 U.S. Market for Cell-based Assays, 20132021 ($ Millions) .. 195
Figure 18 European Market for Cell-Based Assays, 2013-2021 ($ Millions) .. 198
Figure 19 Chinese Drug Discovery Outsourcing Market, 20132021 ($ Millions) .. 200

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