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Cancer Cachexia - Pipeline Review, H1 2015

Published By :

Global Markets Direct

Published Date : Jan 2015

Category :

Cancer

No. of Pages : 118 Pages


Global Markets Directs, Cancer Cachexia Pipeline Review, H1 2015, provides an overview of the Cancer Cachexias therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Cancer Cachexia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Cancer Cachexia and special features on late-stage and discontinued projects.

Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Scope

  • The report provides a snapshot of the global therapeutic landscape of Cancer Cachexia
  • The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in the therapeutics development for Cancer Cachexia and enlists all their major and minor projects
  • The report summarizes all the dormant and discontinued pipeline projects 
  • A review of the Cancer Cachexia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • A detailed assessment of monotherapy and combination therapy pipeline projects
  • Coverage of the Cancer Cachexia pipeline on the basis of target, MoA, route of administration and molecule type
  • Latest news and deals relating related to pipeline products

Reasons to buy

  • Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Identify and understand important and diverse types of therapeutics under development for Cancer Cachexia
  • Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline
  • Devise corrective measures for pipeline projects by understanding Cancer Cachexia pipeline depth and focus of Indication therapeutics
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
  • Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents 2
List of Tables 6
List of Figures 7

Introduction 8
Global Markets Direct Report Coverage 8
Cancer Cachexia Overview 9
Therapeutics Development 10
Pipeline Products for Cancer Cachexia - Overview 10
Pipeline Products for Cancer Cachexia - Comparative Analysis 11
Cancer Cachexia - Therapeutics under Development by Companies 12
Cancer Cachexia - Therapeutics under Investigation by Universities/Institutes 15
Cancer Cachexia - Pipeline Products Glance 16
Late Stage Products 16
Clinical Stage Products 17
Early Stage Products 18
Cancer Cachexia - Products under Development by Companies 19
Cancer Cachexia - Products under Investigation by Universities/Institutes 21
Cancer Cachexia - Companies Involved in Therapeutics Development 22
Acacia Pharma Ltd. 22
Aeterna Zentaris Inc. 23
Amgen Inc. 24
Aphios Corporation 25
Atara Biotherapeutics, Inc. 26
Eli Lilly and Company 27
GTx, Inc. 28
Helsinn Healthcare S.A. 29
Incyte Corporation 30
Novartis AG 31
Ohr Pharmaceutical Inc. 32
PsiOxus Therapeutics, Ltd. 33
Radius Health, Inc. 34
RaQualia Pharma Inc. 35
Vicus Therapeutics, LLC 36
Cancer Cachexia - Therapeutics Assessment 37
Assessment by Monotherapy Products 37
Assessment by Combination Products 38
Assessment by Target 39
Assessment by Mechanism of Action 41
Assessment by Route of Administration 43
Assessment by Molecule Type 45
Drug Profiles 47
(etodolac + propranolol hydrochloride) - Drug Profile 47
Product Description 47
Mechanism of Action 47
R&D Progress 47
(formoterol fumarate + megestrol acetate) - Drug Profile 49
Product Description 49
Mechanism of Action 49
R&D Progress 49
anamorelin hydrochloride - Drug Profile 50
Product Description 50
Mechanism of Action 50
R&D Progress 50
Antibody to Inhibit Parathyroid Hormone Related Protein for Cancer Cachexia - Drug Profile 52
Product Description 52
Mechanism of Action 52
R&D Progress 52
Aptamer to Activate Calcineurin A for Genetic Disorders and Musculoskeletal Disorders - Drug Profile 53
Product Description 53
Mechanism of Action 53
R&D Progress 53
ATA-842 - Drug Profile 54
Product Description 54
Mechanism of Action 54
R&D Progress 54
bimagrumab - Drug Profile 55
Product Description 55
Mechanism of Action 55
R&D Progress 55
DCB-CA2 - Drug Profile 57
Product Description 57
Mechanism of Action 57
R&D Progress 57
dronabinol - Drug Profile 58
Product Description 58
Mechanism of Action 58
R&D Progress 58
Drug to Antagonize ActRIIB for Cancer Cachexia - Drug Profile 59
Product Description 59
Mechanism of Action 59
R&D Progress 59
enobosarm - Drug Profile 60
Product Description 60
Mechanism of Action 60
R&D Progress 60
Espindolol - Drug Profile 62
Product Description 62
Mechanism of Action 62
R&D Progress 62
EXT-400 - Drug Profile 64
Product Description 64
Mechanism of Action 64
R&D Progress 64
LY-2495655 - Drug Profile 65
Product Description 65
Mechanism of Action 65
R&D Progress 65
macimorelin acetate - Drug Profile 66
Product Description 66
Mechanism of Action 66
R&D Progress 66
NBD Peptide - Drug Profile 68
Product Description 68
Mechanism of Action 68
R&D Progress 68
OHR/AVR-118 - Drug Profile 70
Product Description 70
Mechanism of Action 70
R&D Progress 70
RAD-140 - Drug Profile 72
Product Description 72
Mechanism of Action 72
R&D Progress 72
RQ-00432933 - Drug Profile 73
Product Description 73
Mechanism of Action 73
R&D Progress 73
ruxolitinib phosphate - Drug Profile 74
Product Description 74
Mechanism of Action 74
R&D Progress 74
Small Molecule to Agonize Ghrelin Receptor for Cancer Cachexia and Anorexia - Drug Profile 79
Product Description 79
Mechanism of Action 79
R&D Progress 79
Small Molecule to Inhibit ATGL for Cancer Cachexia and Type 2 Diabetes - Drug Profile 80
Product Description 80
Mechanism of Action 80
R&D Progress 80
Synthetic Peptide to Inhibit Melanocortin Receptor for Cancer Cachexia - Drug Profile 81
Product Description 81
Mechanism of Action 81
R&D Progress 81
Synthetic Peptides for Cancer Cachexia - Drug Profile 82
Product Description 82
Mechanism of Action 82
R&D Progress 82
VK-5211 - Drug Profile 83
Product Description 83
Mechanism of Action 83
R&D Progress 83
Cancer Cachexia - Recent Pipeline Updates 85
Cancer Cachexia - Dormant Projects 104
Cancer Cachexia - Discontinued Products 106
Cancer Cachexia - Product Development Milestones 107
Featured News & Press Releases 107
Oct 30, 2014: New Data on Fatigue from ROMANA 1, a Pivotal Phase III Study of Anamorelin in Advanced NSCLC Patients with Cachexia Presented at 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology 107
Dec 11, 2013: Phase II Data on OHR/AVR118 in Advanced Cancer Patients With Cachexia Presented at International Cachexia Conference in Kobe, Japan 108
Oct 24, 2013: GTx Presents Results from Enobosarm POWER Trials for the Prevention and Treatment of Muscle Wasting in Patients with Non-Small Cell Lung Cancer at 15th World Conference on Lung Cancer 109
Mar 21, 2013: Ohr Pharma Announces Results From OHR/AVR118 Phase II Trial In Cancer Cachexia 110
Mar 14, 2013: GTx Announces Publication Of Enobosarm Phase II Trial Results In The Lancet Oncology 111
Mar 04, 2013: PsiOxus Therapeutics Completes Patient Enrollment For Phase II Wasting Disease Therapeutic MT-102 113
Oct 08, 2012: GTx To Present Scientific Poster Presentations On Enobosarm At International Society Of Geriatric Oncology 113
Aug 28, 2012: Aeterna Zentaris Recruits First Patient For Phase IIA Trial In Cancer Cachexia With AEZS-130 114
Jun 25, 2012: GTx Announces Presentation On Enobosarm’s Improvement In Physical Function In Cancer Patients With Both Low And Normal Testosterone Levels 115
Mar 08, 2012: Michael E. DeBakey Veterans Affairs Medical Center Initiates Phase IIa Trial In Cancer Cachexia With Aeterna Zentaris's Ghrelin Agonist, AEZS-130 116

Appendix 117
Methodology 117
Coverage 117
Secondary Research 117
Primary Research 117
Expert Panel Validation 117
Contact Us 117
Disclaimer 118

List of Table


Number of Products under Development for Cancer Cachexia, H1 2015 10
Number of Products under Development for Cancer Cachexia - Comparative Analysis, H1 2015 11
Number of Products under Development by Companies, H1 2015 13
Number of Products under Development by Companies, H1 2015 (Contd..1) 14
Number of Products under Investigation by Universities/Institutes, H1 2015 15
Comparative Analysis by Late Stage Development, H1 2015 16
Comparative Analysis by Clinical Stage Development, H1 2015 17
Comparative Analysis by Early Stage Development, H1 2015 18
Products under Development by Companies, H1 2015 19
Products under Development by Companies, H1 2015 (Contd..1) 20
Products under Investigation by Universities/Institutes, H1 2015 21
Cancer Cachexia - Pipeline by Acacia Pharma Ltd., H1 2015 22
Cancer Cachexia - Pipeline by Aeterna Zentaris Inc., H1 2015 23
Cancer Cachexia - Pipeline by Amgen Inc., H1 2015 24
Cancer Cachexia - Pipeline by Aphios Corporation, H1 2015 25
Cancer Cachexia - Pipeline by Atara Biotherapeutics, Inc., H1 2015 26
Cancer Cachexia - Pipeline by Eli Lilly and Company, H1 2015 27
Cancer Cachexia - Pipeline by GTx, Inc., H1 2015 28
Cancer Cachexia - Pipeline by Helsinn Healthcare S.A., H1 2015 29
Cancer Cachexia - Pipeline by Incyte Corporation, H1 2015 30
Cancer Cachexia - Pipeline by Novartis AG, H1 2015 31
Cancer Cachexia - Pipeline by Ohr Pharmaceutical Inc., H1 2015 32
Cancer Cachexia - Pipeline by PsiOxus Therapeutics, Ltd., H1 2015 33
Cancer Cachexia - Pipeline by Radius Health, Inc., H1 2015 34
Cancer Cachexia - Pipeline by RaQualia Pharma Inc., H1 2015 35
Cancer Cachexia - Pipeline by Vicus Therapeutics, LLC, H1 2015 36
Assessment by Monotherapy Products, H1 2015 37
Assessment by Combination Products, H1 2015 38
Number of Products by Stage and Target, H1 2015 40
Number of Products by Stage and Mechanism of Action, H1 2015 42
Number of Products by Stage and Route of Administration, H1 2015 44
Number of Products by Stage and Molecule Type, H1 2015 46
Cancer Cachexia Therapeutics - Recent Pipeline Updates, H1 2015 85
Cancer Cachexia - Dormant Projects, H1 2015 104
Cancer Cachexia - Dormant Projects (Contd..1), H1 2015 105
Cancer Cachexia - Discontinued Products, H1 2015 106

List of Chart


Number of Products under Development for Cancer Cachexia, H1 2015 10
Number of Products under Development for Cancer Cachexia - Comparative Analysis, H1 2015 11
Number of Products under Development by Companies, H1 2015 12
Comparative Analysis by Clinical Stage Development, H1 2015 17
Comparative Analysis by Early Stage Products, H1 2015 18
Assessment by Monotherapy Products, H1 2015 37
Number of Products by Top 10 Targets, H1 2015 39
Number of Products by Stage and Top 10 Targets, H1 2015 39
Number of Products by Top 10 Mechanism of Actions, H1 2015 41
Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 41
Number of Products by Top 10 Routes of Administration, H1 2015 43
Number of Products by Stage and Top 10 Routes of Administration, H1 2015 43
Number of Products by Top 10 Molecule Types, H1 2015 45
Number of Products by Stage and Top 10 Molecule Types, H1 2015 45

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