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Avastin (Non-Small Cell Lung Cancer) - Forecast and Market Analysis to 2022

Published By :

GlobalData

Published Date : Jun 2013

Category :

Cancer

No. of Pages : 57 Pages


Non-Small Cell Lung Cancer (NSCLC) is the most common lung cancer, and the second-most common cancer in men and women. Historically, the treatment paradigm has centered around chemotherapy. However, the launch of targeted therapies for patients with specific biomarkers has begun to fragment the NSCLC treatment landscape into smaller niche patient populations. Over the forecast period, this trend will continue with the launch of multiple new drugs in several new drug classes to address the high unmet need among NSCLC patients, and provide new treatment options for previously underserved populations. Launch of premium-priced drug candidates combined with increasing incident cases of the disease will be major drivers of growth in the major markets.

Avastin is a first-generation antiangiogenic mAb that is specific for vascular endothelial growth factor (VEGF) and is marketed by Roche/Genentech. It is delivered intravenously in combination with chemotherapy. Avastin is indicated for use by the FDA in the first-line treatment of advanced-stage or recurrent non-squamous NSCLC patients in combination with carboplatin and paclitaxel. It is also approved in the EU and Japan for use as a first-line treatment in combination with platinum-based chemotherapy for non-squamous NSCLC patients.

Scope

  • Overview of NSCLC, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
  • Detailed information on Avastin including product description, safety and efficacy profiles as well as a SWOT analysis.
  • Sales forecast for Avastin for the top nine countries from 2012 to 2022.
  • Sales information covered for the US, France, Germany, Italy, Spain, the UK, Japan, India and China.

Reasons to buy

  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of the competition by understanding the changing competitive landscape for NSCLC
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of Avastin performance
  • Obtain sales forecast for Avastin from 2012-2022 in top nine countries (the US, France, Germany, Italy, Spain, the UK, Japan, India and China)
Table of Contents

1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 7

2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 9
2.3 Upcoming Related Reports 11

3 Disease Overview 12
3.1 Etiology and Pathophysiology 12
3.1.1 Etiology 12
3.1.2 Pathophysiology and Histology 12
3.1.3 NSCLC Biomarkers 13
3.1.4 Quality of Life 14
3.2 Symptoms 15

4 Disease Management 17
4.1 Treatment Overview 17
4.1.1 Diagnosis 19
4.1.2 Clinical Staging 19
4.1.3 Screening and Early Detection 22
4.1.4 Localized Procedures and Therapies 23
4.1.5 Systemic Chemotherapy 24
4.1.6 Targeted Therapy 25

5 Competitive Assessment 28
5.1 Overview 28
5.2 Strategic Competitor Assessment 29

6 Avastin (bevacizumab) 32
6.1 Overview 32
6.2 Efficacy 34
6.3 Safety 35
6.4 SWOT Analysis 35
6.5 Forecast 36

7 Appendix 38
7.1 Bibliography 38
7.2 Abbreviations 43
7.3 Methodology 46
7.4 Forecasting Methodology 46
7.4.1 Number of NSCLC Patients Currently Seeking Treatment 46
7.4.2 Percent Drug-treated Patients 47
7.4.3 General Pricing Assumptions 47
7.4.4 Individual Drug Assumptions 50
7.4.5 Generic Erosion 51
7.5 Physicians and Specialists Included in This Study 51
7.6 Survey of Prescribing Physicians 53
7.7 About the Authors 53
7.7.1 Author 53
7.7.2 Epidemiologist 54
7.7.3 Global Head of Healthcare 55
7.8 About GlobalData 55
7.9 Disclaimer 56

List of Table


Table 1: Symptoms of Disease NSCLC 16
Table 2: Treatment Guidelines for NSCLC 18
Table 3: Stage Definitions for NSCLC 21
Table 4: Treatment Overview by Stage of Diagnosis for NSCLC 27
Table 5: Leading Treatments for NSCLC 31
Table 6: Product Profile Avastin (bevacizumab) 33
Table 7: Avastin SWOT Analysis, 2013 35
Table 8: Global Sales Forecasts ($m) for Avastin, 2012-2022 37
Table 9: Five Year Prevalence 47
Table 10: Physicians Surveyed by Country 53

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