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Published on : Nov 09, 2018

Acute kidney injury is a fatal condition that is diagnosed in nearly 13.3 mn people every year. The condition, also called as renal failure previously, leads to a quick buildup of nitrogenous waste in the kidney, impacting negatively its ability to process urine, often within days or hours of the onset of the disease.

Serious complications are often seen in patients. Nearly 1.7 million deaths are recorded every year across the globe from the condition, making it of utmost importance that the healthy kidneys be protected from damage and treating those who are already afflicted. The proper treatment for the condition, however, still remains a challenge for modern medicine.

A new research could change the scenario or at atleast push research in the field further in a promising direction. Researchers from the University of Wisconsin-Madison and from China have described a new method for the prevention and treatment of acute kidney injury. The technique revolves around the usage of specially designed nano structures.

The rectangular, tubular, and triangular nano structures are built and designed with the help of a method called DNA origami. In this method, the base pairing properties of four nucleotides of a DNA are utilized to design and devise origami nanostructures, called the DNA origami nanostructures. These structures have the capability of self-assembling and favourably accumulating in the kidney.

The experiments that have been conducted in mice as well as kidney cells derived from the human embryo suggest that these structures as active and rapid shield for the kidney and could also help lessen the symptoms of the condition. The study paves way for a set of new treatment mechanisms for acute kidney injury as well as other conditions affecting the kidney.