Antibodies in Oncology Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017 - 2025

Antibodies in Oncology Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017 - 2025

  • Transparency Market Research
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  • Healthcare IT

Report Description

Antibody based cancer therapy has achieved a considerable success in past 15 years. An antibody alternatively known as immunoglobulin is a large Y-shape protein produced by plasma cells that is used by the immune system to identify and neutralize foreign particles such as viruses and bacteria. Therapeutic antibodies have become a significant strategy in clinical oncology owing to their ability to bind with primary and metastatic cancer cells with significant affinity. This leads to the development of anti-cancer/tumor effect out of various means such as direct action of the antibody by immune-mediated cell killing mechanisms, receptor blockage or agonist activities, antibody-dependent cellular cytotoxicity and developing specific effects of an antibody on tumor vasculature and stroma among others. Monoclonal antibodies hold a variety of applications in management of cancer including diagnosis, monitoring as well as treatment of diseases. These monoclonal antibodies are now a days is used by many oncologists to even monitor the disease progression such as estimation and measurement of carcinoembryonic antigen in colon cancer. 

Monoclonal antibodies based on their mechanism of action can be classified into 3 prominent categories such as one which triggers the immune system, blocks tumor cell division signals and at last one which act as a carrier of cancer drugs. Since cancer cells are abnormal in nature and are usually difficult to detect. For triggering an immune system monoclonal antibodies attach themselves to cancerous cells making it easier for the immune systems to track and identify. Prominent antibodies of this type include Rituximab for non-Hodgkin lymphoma (NHL), Alemtuzumab for chronic lymphocytic leukaemia (CLL). There are few monoclonal antibodies that attach themselves to immune cells which can enhance their cell division process so as to produce substantial immune cells to counterattack antibodies depending upon the kind of disease and its stage. For blocking signals with respect to cancerous/tumor cell’s division, some monoclonal antibodies inhibits growth factor receptors responsible for their cell proliferation process. Such kind of monoclonal antibodies include Trastuzumab (Herceptin) for breast and stomach cancer, Panitumumab (Vectibix) for advanced bowel cancer, Bevacizumab (Avastin) for advanced bowel cancer, breast cancer and some other cancers. In another type of monoclonal antibodies which possesses drugs or radiation attached to them. Now, the monoclonal antibodies search, track and delivers drugs and radiation directly to them. 

Some of the FDA approved monoclonal antibodies in oncology encompasses Trastuzumab for ERBB2-positive breast cancer, Bevacizumab for first-line and second-line treatment of metastatic colon cancer, Alemtuzumab against B cell chronic lymphocytic leukemia, Brentuximab vedotin for curing refractory Hodgkin's lymphoma and systemic anaplastic lymphoma among others.  During 2010 and 2011, the therapeutic antibody market was primarily concentrated only towards two prominent categories namely oncology and immunology. In 2010, oncology indications made up just over 50% of sales, while the immunological area accounted for almost 40%. Similar trend is likely to continue for next few years as well since majority of the monoclonal based antibodies are yet in phase 2 and phase 3 clinical trial phases.

One of the key drivers is the increasing prevalence of cancer across globe. According to Cancer Research UK, approximately 14.1 million adults were diagnosed with cancer in 2012 of which 8.2 million deaths happened across the globe.  Monoclonal antibodies are more effective in the treatment of cancer than pharmaceutical drugs and chemotherapies. The increasing trend and use of monoclonal antibodies in the development of personalized medicines will have a positive impact on the market.

Some of the prominent players in antibodies in oncology market include: Amgen Inc., Novartis International AG, Bristol Myers Squibb Co., Corporations Plc, Biogen Idec Inc., Eli Lilly, UCB S.A., Elan Human Genome Sciences Inc., AstraZeneca plc, Daiichi Sankyo, GlaxoSmithKline plc, Pfizer Inc., Bayer AG, Eisai Co. Ltd., and Alexion Pharmaceuticals.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

The study is a source of reliable data on:

  • Market segments and sub-segments
  • Market trends and dynamics
  • Supply and demand
  • Market size
  • Current trends/opportunities/challenges
  • Competitive landscape
  • Technological breakthroughs
  • Value chain and stakeholder analysis

The regional analysis covers:

  • North America (U.S. and Canada)
  • Latin America (Mexico, Brazil, Peru, Chile, and others)
  • Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg)
  • Eastern Europe (Poland and Russia)
  • Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)
  • Middle East and Africa (GCC, Southern Africa, and North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report:

  • A complete backdrop analysis, which includes an assessment of the parent market
  • Important changes in market dynamics
  • Market segmentation up to the second or third level
  • Historical, current, and projected size of the market from the standpoint of both value and volume
  • Reporting and evaluation of recent industry developments
  • Market shares and strategies of key players
  • Emerging niche segments and regional markets
  • An objective assessment of the trajectory of the market
  • Recommendations to companies for strengthening their foothold in the market      

Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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