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Actos (Type 2 Diabetes) Analysis and Forecasts to 2020

Published By :

GlobalData

Published Date : Oct 2011

Category :

Diabetes

No. of Pages : 42 Pages


GlobalDatas pharmaceuticals report, Actos (Type 2 Diabetes) Analysis and Forecasts to 2020 provides Actos sales estimates for US, EU5 and Japan. In addition, it covers detailed clinical assessment of the drug, factors impacting drug sales, competitive landscape, and analysis of sales performance during the forecast period (2002-2020). The report also includes information on Type 2 Diabetes market. This report is built using data and information sourced from GlobalDatas proprietary databases, primary and secondary research using Companys corporate website, SEC filings, investor presentations and featured press releases, both from company and industry-specific third party sources, put together with in-house analysis, by GlobalData's team of industry experts. 

Scope

  • Therapy area profile including patient population for the US, EU5 and Japan (seven major markets)
  • Analysis and review of Actos including historical sales data
  • Qualitative and quantitative assessment of market space
  • Analysis of the trends, drivers and restraints shaping and defining the markets
  • In-depth analysis of Actos including efficacy, safety, pricing, competition and other details which influence its sales potential
  • Detailed sales forecast for 2011-2020 for Actos in each of the seven major markets

Reasons to buy

  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of competition by understanding the changing competitive landscape
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of the drugs performance 
  • Examine the historical sales performance of a drug in seven major markets
  • Obtain sales forecast for currently marketed/pipeline drug for 2011-2020 for all seven major markets
Table of Contents

1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 4

2 Introduction 5
2.1 Diabetes 5
2.2 Epidemiology 5
2.2.1 Prevalence 5
2.2.2 Mortality 7
2.3 Etiology and Risk Factors 9
2.3.1 Obesity 9
2.3.2 Sedentary Lifestyle 9
2.3.3 Family History and Genetics 9
2.3.4 Ethnicity 9
2.3.5 Old Age 9
2.4 Economic Impact of Diabetes 9
2.5 GlobalData Report Guidance 11

3 Type 2 Diabetes: Market Characterization 12

3.1 Type 2 Diabetes Market 12
3.2 Type 2 Diabetes Market Forecasts 13
3.3 Type 2 Diabetes Market: Drivers and Restraints 14
3.3.1 Drivers 14
3.3.2 Restraints 15

4 Classification of Diabetes 16
4.1 Types of Diabetes 16
4.1.1 Type 1 Diabetes 16
4.1.2 Type 2 Diabetes 16
4.1.3 Gestational Diabetes 16
4.2 Diabetes Complications 16
4.2.1 Cardiovascular Disease 16
4.2.2 Nephropathy 17
4.2.3 Neuropathy 17
4.2.4 Amputation 17
4.2.5 Retinopathy 17

5 Evolution of Anti-Diabetic Treatments 18

6 Medications 19

6.1 Insulin 19
6.2 Oral Medications 19
6.2.1 Sulfonylureas (SUR) 19
6.2.2 Biguanides (BGDs) 19
6.2.3 Alpha-Glucosidase Inhibitors (AGI) 21
6.2.4 Meglitinides 21
6.2.5 Thiazolidinediones (TZDs) 22
6.2.6 Dipeptidyl Peptidase IV (DPP- 4) Inhibitors 23
6.2.7 Oral Combination Therapy 23
6.3 Other Injectionable Medications 24
6.3.1 Pramlintide 24
6.3.2 Exenatide 24
6.4 Market Share as per Classes in Type 2 Diabetes 24

7 Actos 25
7.1 Introduction 25
7.2 Mechanism of Action 25
7.3 Clinical Studies 25
7.4 Approval History of Actos 26
7.5 Factors Affecting Sales of Actos 26
7.5.1 Used in Combinations as well as Monotherapy 26
7.5.2 Additional Benefits 26
7.5.3 Reduction in Insulin Requirements 26
7.5.4 Safety Issues 26
7.5.5 Increased Risk of Bladder Cancer 26
7.6 Drug Evaluation 27
7.6.1 Drug Risk Benefit Score 27
7.6.2 Intensity of Competition 27
7.7 Sales Forecasts 28
7.7.1 Target Patient Pool 28
7.7.2 Dosing 28
7.7.3 Annual Cost of Therapy 28
7.7.4 Market Penetration 28
7.7.5 Sales Projections of Actos 28
7.7.6 Sales Projections in the US 30
7.7.7 Sales Projections in the UK 31
7.7.8 Sales Projections in France 32
7.7.9 Sales Projections in Germany 33
7.7.10 Sales Projections in Italy 34
7.7.11 Sales Projections in Spain 35
7.7.12 Sales Projections in Japan 36

8 Diabetes Market: Appendix 38
8.1 Market Definitions 38
8.2 List of Abberiviations 38
8.3 Research Methodology 38
8.3.1 Coverage 39
8.3.2 Secondary Research 39
8.3.3 Forecasting 39
8.3.4 Net Penetration of Drug 40
8.3.5 Net Annual Dosing 40
8.3.6 Annual Cost of Therapy 40
8.3.7 Primary Research 40
8.3.8 Expert Panels 41
8.4 Drug Sales Estimates Model 41
8.5 Contact Us 41
8.6 Disclaimer 41
8.7 Sources 42

List of Table


Table 1: Diabetes, World, Prevalence Estimates for the age group 20-79 years (million), 2000-2030 5
Table 2: Diabetes, Top 10 Countries, by Prevalence (million), 2010 and 2030 7
Table 3: Diabetes, Top 10 Countries, Highest Health Expenditures ($bn), 2010 10
Table 4: Type 2 Diabetes, World, Major Marketed Drugs, 2010 12
Table 5: Type 2 Diabetes, World, Major Pipeline Products in Phase III 13
Table 6: Diabetes, Worldwide, Prevalence Estimates, 2010 and 2030 14
Table 7: Overweight*, Global, Prevalence Estimates in Males Aged 15 and above (%), 2005 15
Table 8: Diabetes Drugs Evolution 18
Table 9: Mean Change from Baseline for FPG and HbA1c in a 26-Week Placebo-Controlled Dose-Ranging Study of Actos 25
Table 10: Drug Risk Benefit Score (DRB)-Actos 27
Table 11: Actos, Type 2 Diabetes, Global, Sales Estimates ($m), 2002-2020 29
Table 12: Actos, Type 2 Diabetes, The US, Sales Estimates ($m), 2002-2018 30
Table 13: Actos, Type 2 Diabetes, The UK, Sales Estimates ($m), 2002-2012 31
Table 14: Actos, Type 2 Diabetes, France, Sales Estimates ($m), 2002-2011 32
Table 15: Actos, Type 2 Diabetes, Germany, Sales Estimates ($m), 2002-2011 33
Table 16: Actos, Type 2 Diabetes, Italy, Sales Estimates ($m), 2002-2012 34
Table 17: Actos, Type 2 Diabetes, Spain, Sales Estimates ($m), 2002-2012 35
Table 18: Actos, Type 2 Diabetes, Japan, Sales Estimates ($m), 2002-2020 36

List of Chart


Figure 1: Diabetes, World, Comparative Prevalence in Age Group 20-79 years (%), 2010 6
Figure 2: Diabetes, World, Comparative Prevalence in Age Group 20-79 years (%), 2030 6
Figure 3: Diabetes, World, Mortality, 2010 7
Figure 4: Top 10 Causes of Mortality, Worldwide, 2008 8
Figure 5: Type 2 Diabetes, Global, Market Size Forecasts ($bn), 20102020 13
Figure 6: Mechanism of Action of Sulfonylurea 19
Figure 7: Mechanism of Action of Biguanide, Thiazolidinediones, Alpha-Glucosidase Inhibitors 20
Figure 8: Mechanism of Action of Metformin and Alpha-Glucosidase Inhibitors 21
Figure 9: Mechanism of Action of Thiazolidinediones 22
Figure 10: Mechanism of Action of DPP IV Inhibitors 23
Figure 11: Type 2 Diabetes, Global, Market Share by Value, By Class (%), 2010 24
Figure 12: Actos, Type 2 Diabetes, Global, Sales Estimates ($m), 2002-2020 29
Figure 13: Actos, Type 2 Diabetes, The US, Sales Estimates ($m), 2002-2018 30
Figure 14: Actos, Type 2 Diabetes, The UK, Sales Estimates ($m), 2002-2012 31
Figure 15: Actos, Type 2 Diabetes, France, Sales Estimates ($m), 2002-2011 32
Figure 16: Actos, Type 2 Diabetes, Germany, Sales Estimates ($m), 2002-2011 33
Figure 17: Actos, Type 2 Diabetes, Italy, Sales Estimates ($m), 2002-2012 34
Figure 18: Actos, Type 2 Diabetes, Spain, Sales Estimates ($m), 2002-2012 35
Figure 19: Actos, Type 2 Diabetes, Japan, Sales Estimates ($m), 2002-2020 36
Figure 20: Actos, Type 2 Diabetes, Global, Sales Distribution (%), 2010 37

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