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2019 Biotechnology Research Review

Published By :

BCC Research

Published Date : Nov 2019

Category :

Biotechnology

No. of Pages : 199 Pages

Report Scope:

Several significant developments have aided and accelerated the growth of markets in biotechnology, in the period of review. Notable recent advancements in biotechnology are CRISPR, Spheroids for drug development, Quantitative Cell Based Assay using high content analysis platform and Luciferase based high-throughput screening assay. Such technologies assure the wide adoption of cell line technologies for drug development, simplify the gene editing process making it cost-effective.

Companies operating in cell line market are investing huge amount in setting up manufacturing units with advanced state of art facility and expanded production facilities. At the same time, the genetic sequencing technology is advancing at a great pace especially in the healthcare sector in diagnosis of various cancers.

Gene therapy technology has opened new avenues which places emphasis on curing disease that do not have an effective therapeutic availability. Johnson & Johnson, together with the University of Pennsylvania, is developing a third-generation AAV-based gene therapy for Alzheimers disease. The goal is to use AAV viral delivery to initiate the expression of therapeutic anti-Alzheimers antibodies in the brain. Novartis launched Zolgensma for the treatment of spinal muscular atrophy. The research represents a novel way to get biologics into the brain to treat Alzheimers disease and other neurological diseases. This is expected to pave way for further innovations in AAV-based gene therapy.

The sector continuously faces some challenges related to marketing, paying for innovation, pricing pressures from the government organizations.

Paying for development costs is always most critical part for the manufacturers. In 2019, gene therapies and many cell biology technologies are developed to address the needs of some important diseases and proven to be effective. However, this comes for a high cost. For example, Zolgensma, a viral vector based gene therapy for the treatment of spinal muscular atrophy costs around $5 million. It is important to figure out how to pay for the innovation which is quite challenging.

The pricing and paying for getting the products to market are important challenges. The innovation may take several years from clinical trial phase to get launched in the market. The investors may be disappointed if the company doesn't show expected profits and loses the hope while stock prices fall. This means that companies must carefully manage expectations and maintain balance.
Table of Contents
Chapter 1 Foreword
Foreword
Chapter 2 Cancer Profiling and Pathways: Technologies and Global Markets (Report Code: BIO073C)
Introduction
Study Goals and Objectives
Reasons for Doing This Study
Intended Audience
Scope of the Report
Methodology
Information Sources
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports
Summary and Highlights
Cancer Profiling and Pathways
Introduction to Cancer Profiling Technologies
Biomarkers
Screening Tests
Early Detection and Diagnosis of Cancer
Pathway Profiling
Molecular Profiling
Cancer Profiling
Clinical Utility of Molecular Profiling
Pathological Classification
Cancer Profiling: Future Goals
Chapter 3 Cell Harvesting Market (Report Code: BIO182A)
Introduction
Study Goals and Objectives
Scope of Report
Research Methodology and Information Sources
Geographic Breakdown
Analyst's Credentials
Related BCC Research Reports
Summary and Highlights
Market and Technology Background
Key Market Trends
Increased Healthcare Spending to Promote the Growth of the Market
Manual Cell Harvesting Will Continue to Account for a Significant Share of the Market
North America Will Continue to Account for a Significant Share of the Market
Emphasis on Innovations in 3D Cell Culture Technology
Key Recommendations
Shifting Focus toward Small and Medium-Sized Enterprises (SMEs)
Increased Number of Partnerships and Collaborations Driving Market Growth
Emphasis on Emerging Economies
Bone Marrow is the Major Source of Stem Cells Used in Harvesting Procedures
Factors Restraining Market Growth
High Treatment and Research Costs
Market Breakdown by Type of Harvesting
Automated Cell Harvesting
Manual Cell Harvesting
Market Breakdown by End User
Research Institutes
Biotechnology and Biopharmaceutical Companies
Hospitals and Clinics
Market Breakdown by Application
Bone Marrow
Adipose Tissue
Peripheral Blood
Umbilical Cord
Chapter 4 Exosome Diagnostics and Therapeutics: Global Markets (Report Code: BIO149C)
Introduction
Study Goals and Objectives
Scope of Report
Information Sources
Intended Audience
Analyst's Credentials
Related BCC Research Reports
Summary and Highlights
Market Overview
Exosome Definition and Nomenclature
Exosomes Biogenesis and Processing
Exosome Components
DNA in Exosomes
Proteins in Exosomes
RNA in Exosomes
Exosome Diagnostic Market
Exosome Therapeutic Market
Market Breakdown by End User
Market Breakdown by Region
Chapter 5 Global DNA Read, Write and Edit Market (Report Code: BIO193A)
Introduction
Study Goals and Objectives
Reasons for Doing the Study
Scope of Report
Methodology
Information Sources
Geographical Breakdown
Analyst's Credentials
Related BCC Research Reports
Summary and Highlights
DNA Read, Write and Edit Technologies and Markets
Large-Scale Initiatives and Consortia
Applications of DNA Read, Write and Edit Technologies
DNA Read, Write and Edit Market Driving Forces
Global DNA Read, Write and Edit Markets
DNA Read, Write and Edit Applications
DNA Read, Write and Edit Markets by Region
Gene Editing Market
Industry Growth-Driving Forces
Chapter 6 Global DNA Sequencing: Research, Applied and Clinical Markets (Report Code: BIO045G)
Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
Related BCC Research Reports
Summary and Highlights
Overview of Technology
Sequencing Markets
Sequencing Growth Driving Forces
Sequencing Applications
Sequencing Industry
Market Drivers
Chapter 7 Global Stem Cell and Regenerative Therapy Market: A BCC Research Outlook (Report Code: BIO191A)
Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
Related BCC Research Reports
Summary and Highlights
Introduction to Technology
Stem Cell Research Centers
Stem Cell Production
Customized Therapy
Market Dynamnis
Market Drivers
Market Restraints
Market Breakdown by Product
Global Stem Cell and Regenerative Medicines Market, by Product
Therapeutic Products
Cell Therapies
Tissue Engineering
Gene Therapy
Cell Banking
Tools and Reagents
Chapter 8 Protein Expression: Global Markets (Report Code: BIO165A)
Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources and Methodology
Intended Audience
Geographic Breakdown
Analyst's Credentials
Related BCC Research Reports
Summary and Highlights
Introduction to Technology
Market Definition
Protein Expression Market Overview
Introduction to Protein Expression Systems
Protein Synthesis Machinery
What is Protein Expression?
How Proteins Are Made?
Transcription and Translation
Perfusion Approaches and Supporting Practices (e.g., Continuous Bio Manufacturing and Digital and Model-based Controls)
Post-translational Modification
Cloning Technologies
Constitutive and Inducible Promoters Commonly Used in Recombinant Protein Expression Systems
Production of Recombinant Proteins
Comparison of Expression Systems
Problems Associated with the Production of Protein
Ongoing Clinical Trials for Protein Expression
Global Market for Protein Expression Systems by Type
Global Market for Protein Expression by Products and Services
Global Market for Protein Expression by Application
Global Market for Protein Expression by End User
Chapter 9 Viral Vector and Plasmid DNA: Technologies and Global Markets (Report Code: BIO192A)
Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
Related BCC Research Reports
Summary and Highlights
Introduction to Technology
Gene Therapy
Plasmid Production
Description of Market Trends
Market Dynamics
Market Drivers
Market Restrictions
Opportunity
Market Breakdown by Product Type
Plasmid DNA
Viral Vector
Market Breakdown by End User
Research Institutes
Pharmaceutical and Biopharmaceutical Companies
Market Breakdown by Application
Cancer
Infectious Diseases
CVD
Other Applications
Market Breakdown by Region

List of Table

List of Tables
Table 1 : Global Market for Cancer Profiling Technologies, by Type, Through 2023
Table 2 : Technical Approaches for Tumor Molecular Profiling
Table 3 : Different Tools for Molecular Profiling of Cancer
Table 4 : Global Market for Cell Harvesting, by Component/Equipment, Through 2023
Table 5 : Cost of Stem Cell Therapies, 2017
Table 6 : Global Market for Cell Harvesting, by Type, Through 2023
Table 7 : Global Market for Automated Cell Harvesting, by Region, Through 2023
Table 8 : Global Market for Manual Cell Harvesting, by Region, Through 2023
Table 9 : Global Market for Cell Harvesting, by End User, Through 2023
Table 10 : Global Market for Cell Harvesting in Research Institutes, by Region, Through 2023
Table 11 : Research Institutes in the Cell Harvesting Market
Table 12 : Global Market for Cell Harvesting in Biotechnology and Biopharmaceutical Companies, by Region, Through 2023
Table 13 : Global Market for Cell Harvesting in Hospitals and Clinics, by Region, Through 2023
Table 14 : Hospitals and Clinics in the Cell Harvesting Market
Table 15 : Global Market for Cell Harvesting, by Procedure, Through 2023
Table 16 : Global Market for Bone Marrow Cell Harvesting Procedures, by Region, Through 2023
Table 17 : Types of Bone Marrow Transplants
Table 18 : Global Market for Adipose Tissue Cell Harvesting Procedures, by Region, Through 2023
Table 19 : Global Market for Peripheral Blood Cell Harvesting Procedures, by Region, Through 2023
Table 20 : Examples of Growth Factors Secreted, by Platelets
Table 21 : Global Market for Umbilical Cord Cell Harvesting Procedures, by Region, Through 2023
Table 22 : Global Market for Exosome Diagnostics and Therapeutics, by Product, Through 2023
Table 23 : Nomenclature of Exosome Particles
Table 24 : Examples of Exosomal Proteins for Clinical Diagnostic Applications
Table 25 : Examples of Studies Using Extracellular Vesicles as Drug Delivery Vehicles
Table 26 : Examples of Engineering Exosome for Cargo Delivery
Table 27 : Global Market for Exosome Therapeutics and Diagnostics, by End User, Through 2023
Table 28 : Global Market for Exosome Diagnostics and Therapeutics, by Region, Through 2023
Table 29 : Global Market for DNA Read, Write and Edit, by Application, Through 2024
Table 30 : Report Scope
Table 31 : Impact of Large-scale Initiatives on the Read, Write and Edit Industry
Table 32 : Driving Forces of DNA Read, Write and Edit Industry Growth
Table 33 : Global Market for DNA Read, Write and Edit, by End User, Through 2024
Table 34 : Summary of Applications for DNA Read, Write and Edit Technologies
Table 35 : Global DNA Read, Write and Edit Market, by Region, Through 2024
Table 36 : Global Market for Gene Editing, by End User, Through 2024
Table 37 : Driving Forces for Growth in the DNA Read, Write and Edit Industry
Table 38 : Global Sequencing Market, by Delivered Format, Through 2023
Table 39 : DNA Report Scope
Table 40 : Global Sequencing Market, by Product Type, Through 2023
Table 41 : Global Sequencing Market, by Format, Through 2023
Table 42 : DNA Sequencing Market Growth Driving Forces
Table 43 : Sequencing End Users and Applications
Table 44 : Key Sequencing Industry Participants by Sector
Table 45 : Sequencing Market Growth Driving Forces
Table 46 : Global Stem Cell and Regenerative Medicines Market, by Region, Through 2024
Table 47 : Snapshot of Regenerative Product Pipeline
Table 48 : Ethical Issues in Different Phases of Stem Cell Research
Table 49 : Global Stem Cell and Regenerative Medicines Market, by Product, Through 2024
Table 50 : Global Stem Cell and Regenerative Therapeutic Products Market, by Type, Through 2024
Table 51 : Global Market for Protein Expression, by Region, Through 2022
Table 52 : Advantages and Disadvantages of Protein Expression Systems
Table 53 : Prokaryotes vs. Eukaryotes Protein Synthesis
Table 54 : Comparison of Expression Systems
Table 55 : Ongoing Clinical Trials (List 1)
Table 56 : Ongoing Clinical Trials (List 2)
Table 57 : Global Market for Protein Expression Systems, by Type, Through 2022
Table 58 : Global Market for Protein Expression, by Products and Services, Through 2022
Table 59 : Global Market for Protein Expression, by Application, Through 2022
Table 60 : Global Market for Protein Expression, by End User, Through 2022
Table 61 : Types of Gene Therapy
Table 62 : Clinical Trials for Viral Vector-Mediated Gene Therapy in the U.S., 2018 and 2019
Table 63 : Partnerships for Viral Vector-Mediated Gene Therapy
Table 64 : Global Market for Viral Vector and Plasmid DNA, by Product Type, Through 2024
Table 65 : Global Market for Plasmid DNA, by Region, Through 2024
Table 66 : Global Market for Viral Vector, by Region, Through 2024
Table 67 : Global Market for Viral Vector and Plasmid DNA, by End User, Through 2024
Table 68 : Global Market for Viral Vector and Plasmid DNA in Research Institutes, by Region, Through 2024
Table 69 : Global Market for Viral Vector and Plasmid DNA in Pharmaceutical and Biopharmaceutical Companies, by Region, Through 2024
Table 70 : Global Market for Viral Vector and Plasmid DNA, by Application, Through 2024
Table 71 : Global Market Viral Vector and Plasmid DNA in Cancer, by Region, Through 2024
Table 72 : Pipeline Products for Cancer Gene Therapy, 2018 and 2019
Table 73 : Global Market for Viral Vector and Plasmid DNA in Infectious Diseases, by Region, Through 2024
Table 74 : Gene Transfer Vectors Used in Heart Gene Therapy
Table 75 : Global Market for Viral Vector and Plasmid DNA in CVD, by Region, Through 2024
Table 76 : Global Market for Viral Vector and Plasmid DNA in Other Applications, by Region, Through 2024
Table 77 : Global Market for Viral Vector and Plasmid DNA, by Region, Through 2024

List of Chart

List of Figures
Figure 1 : Global Market for Cancer Profiling Technologies, by Type, 2017-2023
Figure 2 : Global Market for Cell Harvesting, by Component/Equipment, 2017-2023
Figure 3 : Global Market for Exosome Diagnostics and Therapeutics, by Product, 2017-2023
Figure 4 : Global Market for DNA Read, Write and Edit, by Application, 2017-2024
Figure 5 : Global Sequencing Market, by Delivered Format, 2017-2023
Figure 6 : Global Stem Cell and Regenerative Medicines Market Share, by Region, 2018
Figure 7 : Global Stem Cell and Regenerative Medicines Market Share, by Product, 2018
Figure 8 : Global Stem Cell and Regenerative Therapeutic Products Market, 2018-2024
Figure 9 : Global Stem Cell and Regenerative Therapeutic Products Market Share, by Type, 2018
Figure 10 : Global Cell Therapy Market, 2018-2024
Figure 11 : Global Tissue Engineering Market, 2018-2024
Figure 12 : Global Gene Therapy Market, 2018-2024
Figure 13 : Global Cell Banking Market, 2018-2024
Figure 14 : Global Tools and Reagents Market, 2018-2024
Figure 15 : Global Market for Protein Expression, by Region, 2016-2022
Figure 16 : Protein Expression Workflow
Figure 17 : Share of Clinical Trials Performed for Protein Expression, by Region, 2009-2018
Figure 18 : Processes of Gene Therapy Research
Figure 19 : Processes of Gene Therapy Development
Figure 20 : Typical Production Process Flow for Viral Vectors
Figure 21 : Most Common Cancer Types, Global Cases, 2018
Figure 22 : Progression of cGMP Compliance for Drug Development

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