10-Deacetylbaccatin III, also known as 10-DAB or 10-DAB III, is a closely related natural organic compounds isolated from dried needles and small branches of the European yew tree (Taxus baccata).10-Deacetylbaccatin III is a precursor to the anti-cancer drug docetaxel (Taxotere). pacitaxel (taxol); cabazitaxel. 10-10-deacetylbaccatin III was found to selectively inhibit the growth of L. DONOVANI intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC(50) value of 70 nM. 10-deacetylbaccatin III is an intermediate in the biosynthetic pathway of the taxane, paclitaxel. Taxanes disrupt mitosis by preventing microtubule destabilization and spindle fiber formation in animal cells (Molè-Bajer, 1983). As a consequence of this mechanism, yew trees are slow growing organisms.
As new companies enter the market for finished paclitaxel, bulk demand will increase as competition forces down prices, the study notes, adding that, with the drug becoming more affordable, physicians are expected to prescribe it more freely. However, while demand may be rising, paclitaxel is derived from a natural resource, and its long-term availability is in question.
10-Deacetylbaccatin III is used as a chemical intermediate in the preparation of the anti-cancer drug paclitaxel (Taxol). It is used to study the taxol biosynthetic pathway. 10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated.
10-deacetylbaccatin III (10-DAB) is the fifth intermediate in the biosynthetic pathway of paclitaxel in Taxus species (Walker, 2000). 10-DAB is isolated from the needles (leaves) and roots of the Canadian Yew tree, Taxus canadensis, the American ornamental Yew Tree, Taxus media “hicksii” or the European Yew Tree, Taxus baccata, utilizing patented SuperFluids™CXP technology [Castor, US Patent] followed by segmentation chromatography. 10-DAB is used as the core starting material in the semi-synthetic manufacturing of paclitaxel [Holton, 1991]. 10-DAB is also used as the starting raw material for docetaxel (Taxotere®), a potent anticancer compound.
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