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Traumatic Brain Injury Therapeutics - Pipeline Assessment and Market Forecasts to 2019

Published By :

GlobalData

Published Date : Jun 2012

Category :

Therapeutic Area

No. of Pages : 98 Pages


GlobalData, the industry analysis specialist, has released its new report, Traumatic Brain Injury Therapeutics - Pipeline Assessment and Market Forecasts to 2019. The report is an essential source of information and analysis on the global Traumatic Brain Injury Therapeutics market. The report identifies the key trends shaping and driving the global Traumatic Brain Injury Therapeutics market. The report also provides insights on the prevalent competitive landscape and the emerging players expected to significantly alter the market positioning of the current market leaders. Most importantly, the report provides valuable insights on the pipeline products within the global Traumatic Brain Injury Therapeutics sector. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts

Scope

The report provides information on the key drivers and challenges of the Traumatic Brain Injury Therapeutics market. Its scope includes -
  • Annualized seven key markets (US, France, Germany, Italy, Spain, UK and Japan) Traumatic Brain Injury Therapeutics market revenues data from 2006 to 2011, forecast for eight years to 2019. 
  • Pipeline analysis data providing a split across the different phases, mechanisms of action being developed and emerging trends by seven key markets. Pipeline candidates fall under major therapeutic classes.
  • Analysis of the current and future competition in the seven key countries Traumatic Brain Injury Therapeutics market. 
  • Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide a qualitative analysis of its implications. 
  • Key topics covered include strategic competitor assessment, market characterization, unmet needs and the implications for the Traumatic Brain Injury Therapeutics market.
  • Analysis of key recent licensing and partnership agreements in Traumatic Brain Injury Therapeutics market 
Reasons to buy

The report will enhance your decision making capability. It will allow you to -
  • Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies and by identifying the companies with the most robust pipeline. 
  • Develop business strategies by understanding the trends shaping and driving the global Traumatic Brain Injury Therapeutics market. 
  • Drive revenues by understanding the key trends, innovative products and technologies, market segments and companies likely to impact the global Traumatic Brain Injury Therapeutics market in future. 
  • Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors. 
  • Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage. 
  • Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships. 
  • Whats the next big thing in the global Traumatic Brain Injury Therapeutics market landscape? Identify, understand and capitalize.
Table of Contents

1 Table of Contents
1 Table of Contents 3
1.1 List of Tables 5
1.2 List of Figures 7

2 Traumatic Brain Injury Therapeutics - Introduction 8
2.1 Disease Overview 8
2.1.1 Classification of Traumatic Brain Injury 9
2.1.2 Types of Traumatic Brain Injury 11
2.1.3 Effects of Traumatic Brain Injury 12
2.1.4 Post-Injury Complications Associated with Traumatic Brain Injury 13
2.2 Epidemiology 14
2.2.1 Traumatic Brain Injury: A Silent Epidemic in the US 16
2.2.2 The UK 17
2.2.3 Spain 17
2.2.4 France 17
2.2.5 Italy 17
2.2.6 Germany 17
2.2.7 Japan 17
2.2.8 Mortality 18
2.2.9 Quality of Life Parameters 19
2.2.10 Pharmacoeconomic Burden 19
2.3 Etiology 19
2.4 Pathophysiology 21
2.4.1 Primary Injury 21
2.4.2 Secondary Injury 22
2.4.3 Inflammatory Response 23
2.4.4 Repair-Regeneration 23
2.5 Signs and Symptoms 23
2.6 Diagnosis 24
2.6.1 Initial Measures 24
2.6.2 Complete Clinical Evaluation 25
2.7 Treatment and Management Pattern 28
2.7.1 Acute Management of Traumatic Brain Injury in Hospital 28
2.7.2 Treatment of Mild Traumatic Brain Injury 33
2.7.3 Treatment of Post-Traumatic Brain Injury Complications 36
2.7.4 Rehabilitation 39
2.8 Referral Pathway 39
2.9 GlobalData Pipeline Report Guidance 41

3 Traumatic Brain Injury Therapeuctics - Market Characterization 42
3.1 Overview 42
3.2 Traumatic Brain Injury Therapeutics Market Size (20062011) Global 43
3.3 Traumatic Brain Injury Therapeutics Market Forecast (20112019) Global 44
3.4 Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury Global 45
3.5 Traumatic Brain Injury Therapeutics Market Size (20062011) The US 46
3.6 Traumatic Brain Injury Therapeutics Market Forecast (20112019) The US 47
3.7 Traumatic Brain Injury Therapeutics Market Distribution based on Severity of Injury The US 48
3.8 Traumatic Brain Injury Therapeutics Market Size (20062011) France 49
3.9 Traumatic Brain Injury Therapeutics Market Forecast (20112019) France 50
3.10 Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, France 51
3.11 Traumatic Brain Injury Therapeutics Market Size (20062011) Germany 52
3.12 Traumatic Brain Injury Therapeutics Market Forecast (2011-2019) Germany 53
3.13 Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, Germany 54
3.14 Traumatic Brain Injury Therapeutics Market Size (20062011) Italy 55
3.15 Traumatic Brain Injury Therapeutics Market Forecast (20112019) Italy 56
3.16 Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, Italy 57
3.17 Traumatic Brain Injury Therapeutics Market Size (20062011) Spain 58
3.18 Traumatic Brain Injury Therapeutics Market Forecast (20112019) Spain 59
3.19 Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, Spain 60
3.20 Traumatic Brain Injury Therapeutics Market Size (20062011) The UK 61
3.21 Traumatic Brain Injury Therapeutics Market Forecast (20112019) The UK 62
3.22 Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, The UK 63
3.23 Traumatic Brain Injury Therapeutics Market Size (20062011) Japan 64
3.24 Traumatic Brain Injury Therapeutics Market Forecast (20112019) Japan 65
3.25 Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, Japan 66
3.26 Drivers and Barriers for Traumatic Brain Injury Therapeutics Market 67
3.26.1 Drivers for Traumatic Brain Injury Therapeutics Market 67
3.26.2 Barriers for TBI Therapeutics Market 67
3.27 Opportunity and Unmet Need Analysis 69
3.27.1 Opportunity and Unmet Need in Traumatic Brain Injury Therapeutics Market 69
3.28 Key Takeaway 69

4 Traumatic Brain Injury Therapeutics - Competitive Assessment 70
4.1 Overview 70
4.2 Strategic Competitor Assessment 70
4.3 Product Profile for the Major Product in the Traumatic Brain Injury Therapeutics 70
4.3.1 Mannitol 70
4.4 Key Takeaway 71

5 Traumatic Brain Injury Therapeutics - Pipeline Assessment 72
5.1 Overview 72
5.2 Strategic Pipeline Assessment 72
5.3 Traumatic Brain Injury Therapeutics Pipeline Pipeline by Phases of Development 73
5.3.1 Traumatic Brain Injury Therapeutics Phase III Pipeline 73
5.3.2 Traumatic Brain Injury Therapeutics Phase II Pipeline 73
5.3.3 Traumatic Brain Injury Therapeutics Phase I/II Pipeline 74
5.3.4 Traumatic Brain Injury Therapeutics Phase I Pipeline 74
5.3.5 Traumatic Brain Injury Therapeutics IND Filed 74
5.3.6 Traumatic Brain Injury Therapeutics Preclinical Phase 75
5.3.7 Traumatic Brain Injury Therapeutics Discovery Pipeline 75
5.4 Technology Trends Analytic Framework 76
5.5 Traumatic Brain Injury Therapeutics Market Pipeline by Mechanism of Action 78
5.6 Molecule Profiling for Promising Drug under Clinical development 79
5.6.1 BHR-100 79
5.7 Key Takeaway 80

6 Traumatic Brain Injury Therapeutics - Clinical Trials Mapping 81
6.1 Clinical Trials by Region/ Country 81
6.2 Clinical Trials by Phase 82
6.3 Clinical Trials by Trial Status 83
6.4 Top 10 companies participating in Therapeutics Clinical Trials 84
6.5 Prominent Sponsors 85

7 Traumatic Brain Injury Therapeutics - Strategic Assessment 87
7.1 Key Events Impacting the Future Traumatic Brain Injury Market 87
7.2 Implications for Future Traumatic Brain Injury Market Competition 88

8 Traumatic Brain Injury Therapeutics - Future Players 89
8.1 Introduction 89
8.2 Company Profiles 89
8.2.1 BHR Pharma, LLC 89

9 Traumatic Brain Injury Therapeutics - Appendix 90
9.1 Market Definitions 90
9.2 Abbreviations 90
9.3 Bibliography 91
9.4 Research Methodology 93
9.4.1 Coverage 93
9.4.2 Secondary Research 94
9.4.3 Primary Research 94
9.4.4 Modelling and Forecasting 94
9.4.5 Expert Panel Validation 97
9.5 Contact Us 97
9.6 Disclaimer 98

List of Table


Table 1: Glasgow Coma Scale 9
Table 2: Clinical Severity (Injury Severity Score) 10
Table 3: Severity of Brain Injury 10
Table 4: Structural Damage (CT) 11
Table 5: Types of Traumatic Brain Injury 11
Table 6: Immediate Post-Injury Complications 13
Table 7: Long-Term Complications Associated with Traumatic Brain Injury 14
Table 8: Incidence Pool of Traumatic Brain Injury Patients in Seven Major Markets 14
Table 9: Rates of Disability in the General Population of the US 16
Table 10: Key Opinion Leader Insights, Mortality Rate of Traumatic Brain Injury in the US, the UK and Japan 18
Table 11: Symptoms of Traumatic Brain Injury 23
Table 12: Frequency of Mild Traumatic Brain Injury Symptoms in General Population and in Traumatic Brain Injury Patients 24
Table 13: Severity Assessment of Traumatic Brain Injury based on GCS 24
Table 14: Key Opinion Leader Insights, Diagnosis Rate of Traumatic Brain Injury in the US, the UK and Japan 27
Table 15: Key Opinion Leader Insights, Percentage of Traumatic Brain Injury Patients Develop Complications 29
Table 16: Key Opinion Leader Insights, Geographical Differences in Treatment and Management Pattern of Medical Complications of Traumatic Brain Injury, 2012 32
Table 17: Treatment and Management of Headache (Includes Tension and Migraine) 33
Table 18: Treatment and Management of Dizziness and Disequilibrium 34
Table 19: Treatment and Management of Fatigue and Sleep Disturbances 34
Table 20: Treatment and Management of Vision, Hearing, Olfactory Symptoms 34
Table 21: Treatment and Management of Irritability 35
Table 22: Treatment and Management of Appetite Changes and Nausea 35
Table 23: Management of Traumatic Brain Injury Sequelaes with Pharmacological Agents 37
Table 24: Traumatic Brain Injury Therapeutics Market, Global, Market Size, ($m), 20062011 43
Table 25: Traumatic Brain Injury Therapeutics Market, Global, Forecast ($m), 20112019 44
Table 26: Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, Global 45
Table 27: Traumatic Brain Injury Therapeutics Market, The US, Market Size, ($m), 20062011 46
Table 28: Traumatic Brain Injury Therapeutics Market, The US, Forecast ($m), 20112019 47
Table 29: Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of TBI, The US 48
Table 30: Traumatic Brain Injury Therapeutics Market, France, Market Size, ($m), 20062011 49
Table 31: Traumatic Brain Injury Therapeutics Market, France, Forecast ($m), 20112019 50
Table 32: Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, France 51
Table 33: Traumatic Brain Injury Therapeutics Market, Germany, Market Size, ($m), 20062011 52
Table 34: Traumatic Brain Injury Therapeutics Market, Germany, Forecast ($m), 20112019 53
Table 35: Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, Germany 54
Table 36: Traumatic Brain Injury Therapeutics Market, Italy, Market Size, ($m), 20062011 55
Table 37: Traumatic Brain Injury Therapeutics Market, Italy, Forecast ($m), 20112019 56
Table 38: Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, Italy 57
Table 39: Traumatic Brain Injury Therapeutics Market, Spain, Market Size, ($m), 20062011 58
Table 40: Traumatic Brain Injury Therapeutics Market, Spain, Forecast ($m), 20112019 59
Table 41: Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of TBI, Spain 60
Table 42: Traumatic Brain Injury Therapeutics Market, The UK, Market Size, ($m), 20062011 61
Table 43: Traumatic Brain Injury Therapeutics Market, The UK, Forecast ($m), 20112019 62
Table 44: Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, The UK 63
Table 45: Traumatic Brain Injury Therapeutics Market, Japan, Market Size, ($m), 20062011 64
Table 46: Traumatic Brain Injury Therapeutics Market, Japan, Forecast ($m), 20112019 65
Table 47: Traumatic Brain Injury Therapeutics Market Distribution based upon Severity of Injury, The UK 66
Table 48: Traumatic Brain Injury Therapeutics Phase III Clinical Pipeline, 2012 73
Table 49: Traumatic Brain Injury Therapeutics Phase II Clinical Pipeline, 2012 73
Table 50: Traumatic Brain Injury Therapeutics Phase I/II Clinical Pipeline, 2012 74
Table 51: Traumatic Brain Injury Therapeutics Phase I Clinical Pipeline, 2011 74
Table 52: Traumatic Brain Injury Therapeutics IND Filed, 2012 74
Table 53: Traumatic Brain Injury Therapeutics Preclinical Pipeline, 2012 75
Table 54: Traumatic Brain Injury Therapeutics Discovery Pipeline, 2012 75
Table 55: Traumatic Brain Injury Therapeutics Market, Clinical Trials by Region/ Country, 2012 81
Table 56: Traumatic Brain Injury Therapeutics Market, Clinical Trials by Phase, 2012 82
Table 57: Traumatic Brain Injury Therapeutics Market, Clinical Trials by Trial Status, 2012 83
Table 58: Traumatic Brain Injury Therapeutics Market, Clinical Trials by Top Companies Participating in Traumatic Brain Injury Therapeutics Clinical Trials, 2012 84
Table 59: Traumatic Brain Injury Therapeutics Market Clinical Trials by Overall Sponsors, 2012 85
Table 60: Traumatic Brain Injury Therapeutics Market Clinical Trials by Prominent Sponsors, 2012 86
Table 61: BHR Pharma Central Nervous System Pipeline Products, 2011 89

List of Chart


Figure 1: Effects of Traumatic Brain Injury 12
Figure 2: Key Opinion Leader Insights, Incidence Trend of Traumatic Brain Injury in the US, the UK and Japan 15
Figure 3: Comparison of Annual Incidence of Traumatic Brain Injury with Other Diseases 16
Figure 4: Average Annual Rates for Traumatic Brain Injury Deaths, by Age Group and Sex- The US, 1997-2007 18
Figure 5: Causes of Traumatic Brain Injury 20
Figure 6: Processes in Traumatic Brain Injury 21
Figure 7: Various Pathological Findings Detected in CT Scan in Traumatic Brain Injury Patients 26
Figure 8: Diagnostic Approaches in Traumatic Brain Injury 27
Figure 9: Post-Traumatic Brain Injury Medical Complications 36
Figure 10: Treatment Continuum of Traumatic Brain Injury 39
Figure 11: Key Opinion Leader Insights, Referral Pathway of Traumatic Brain Injury in the US, the UK and Japan 40
Figure 12: Traumatic Brain Injury Therapeutics Market, Global, Market Size ($m), 20062011 43
Figure 13: Traumatic Brain Injury Therapeutics Market, Global, Forecast ($m), 20112019 44
Figure 14: Traumatic Brain Injury Therapeutics Market, The US, Market Size ($m), 20062011 46
Figure 15: Traumatic Brain Injury Therapeutics Market, The US, Forecast ($m), 20112019 47
Figure 16: Traumatic Brain Injury Therapeutics Market, France, Market Size ($m), 20062011 49
Figure 17: Traumatic Brain Injury Therapeutics Market, France, Forecast ($m), 20112019 50
Figure 18: Traumatic Brain Injury Therapeutics Market, Germany, Market Size ($m), 20062011 52
Figure 19: Traumatic Brain Injury Therapeutics Market, Germany, Forecast ($m), 20112019 53
Figure 20: Traumatic Brain Injury Therapeutics Market, Italy, Market Size ($m), 20062011 55
Figure 21: Traumatic Brain Injury Therapeutics Market, Italy, Forecast ($m), 20112019 56
Figure 22: Traumatic Brain Injury Therapeutics Market, Spain, Market Size ($m), 20062011 58
Figure 23: Traumatic Brain Injury Therapeutics Market, Spain, Forecast ($m), 20112019 59
Figure 24: Traumatic Brain Injury Therapeutics Market, The UK, Market Size ($m), 20062011 61
Figure 25: Traumatic Brain Injury Therapeutics Market, The UK, Forecast ($m), 20112019 62
Figure 26: Traumatic Brain Injury Therapeutics Market, Japan, Market Size ($m), 20062011 64
Figure 27: Traumatic Brain Injury Therapeutics Market, Japan, Forecast ($m), 20112019 65
Figure 28: Projected Growth in Road Traffic Fatalities, 20022020: A Comparison of World Bank Projections with Global Burden of Disease Projections 68
Figure 29: Key Opinion Leader Insights, Unmet Need in Traumatic Brain Injury Therapeutics Market 69
Figure 30: Traumatic Brain Injury Therapeutics Pipeline by Phase of Development, 2012 73
Figure 31: Technology Trends Analytic Framework of the Traumatic Brain Injury Therapeutics Pipeline, 2012 76
Figure 32: Technology Trends Analytic Framework of the Traumatic Brain Injury Therapeutics Pipeline- Description, 2012 77
Figure 33: Traumatic Brain Injury Therapeutics, Pipeline by Mechanism of Action, 2011 78
Figure 34: Traumatic Brain Injury Therapeutics Market Clinical Trials by Region/Country, 2012 81
Figure 35: Traumatic Brain Injury Therapeutics Market Clinical Pipeline by Phase, 2012 82
Figure 36: Traumatic Brain Injury Therapeutics Market Clinical Trials by Trial Status, 2012 83
Figure 37: Traumatic Brain Injury Therapeutics Market, Clinical Trials by Top Companies Participating in Traumatic Brain Injury Therapeutics Clinical Trials, 2012 84
Figure 38: Traumatic Brain Injury Therapeutics Market Clinical Trials by Overall Sponsors, 2012 85
Figure 39: Traumatic Brain Injury Therapeutics Market Clinical Trials by Prominent Sponsors, 2012 86
Figure 40: Traumatic Brain Injury Therapeutics Market, Drivers and Barriers, 2012 87
Figure 41: Implications for Future Market Competition in the Traumatic Brain Injury Therapeutics Market, 2011 88
Figure 42: GlobalData Market Size Estimation 95
Figure 43: GlobalData Market Forecasting Model 97

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