ResearchMoz

Systemic Psoriasis Therapeutics in Major Developed Markets to 2020 - Continued Uptake of Biologics and Novel Pipeline Drugs to Drive Growth Description

GBI Research
Published Date » 2014-02-06
No. Of Pages » 101
   
 GBI Research has released its pharma report “Systemic Psoriasis Therapeutics in Major Developed Markets to 2020 - Continued Uptake of Biologics and Novel Pipeline Drugs to Drive Growth”. The systemic psoriasis market is forecast to grow substantially over the forecast period from $5.0 billion in 2013 to $10.4 billion in 2020, across the eight major markets. This growth will be driven by a rising treatment population and the continued uptake of biologics. Biologics will continue to drive market growth despite leading brands Enbrel (etanercept), Humira (adalimumab) and Remicade (infliximab) losing patent protection in most of the major markets over the forecast period. Although the market will suffer revenue losses as a result of sales erosion from biosimilar...
Table of Content

1 Table of Contents 1
1.1 List of Tables 4
1.2 List of Figures 5

2 Executive Summary 6
2.1 Changes to Treatment Usage Patterns will Drive Market Growth 6
2.2 Biologics to Gain Prominence as Promising Novel Drugs Enter the Market 6

3 Introduction 7
3.1 Overview 7
3.2 Epidemiology 8
3.3 Etiology, Co-morbidities and Risk Factors 9
3.3.1 Genetics 9
3.3.2 Psoriatic Arthritis 9
3.3.3 Mental Health Disorders 10
3.3.4 Metabolic Syndrome, Smoking, Diet and Alcohol Consumption 10
3.3.5 Infections 10
3.3.6 Köebner Phenomenon 11
3.3.7 Other Immune-mediated Diseases 11
3.4 Pathophysiology 11
3.5 Diagnosis 12
3.6 Treatment Options 12
3.6.1 Pharmacological Therapies 13
3.6.2 Non-pharmacological Therapies 14
3.6.3 Combination and Rotational Therapies 14
3.6.4 Quality of Life Assessments 15
3.7 Summary 15
3.8 GBI Research Report Guidance 15

4 Marketed Products 16
4.1 Overview 16
4.2 Methotrexate-based Products 16
4.3 Sandimmune/Neoral (cyclosporine/modified cyclosporine) – Novartis 17
4.4 Soriatane (acitretin) – Steifel Laboratories 18
4.5 Fumaderm (dimethyl fumarate and ethyl fumarate) – Biogen Idec 19
4.6 Humira (adalimumab) – Abbvie Inc. 20
4.7 Enbrel (etanercept) – Amgen Inc. 21
4.8 Remicade (infliximab) – Janssen Biotech 22
4.9 Stelara (ustekinumab) – Janssen Biotech 23
4.10 Marketed Products Heat Map 24

5 Pipeline 27
5.1 Overview 27
5.2 Pipeline Size and Distribution by Phase, Molecule Type and Program Type 28
5.3 Pipeline Distribution by Molecular Target 30
5.4 Clinical Trial Landscape 32
5.4.1 Clinical Trial Duration 32
5.4.2 Clinical Trial Size 36
5.5 Clinical trial failure rates 40
5.6 Primary and Secondary Endpoints 41
5.7 Summary of Psoriasis Clinical Trials 43
5.8 Promising pipeline molecules 43
5.8.1 Ixekizumab – Eli Lilly 43
5.8.2 Xeljanz (tofacitinib) – Pfizer 44
5.8.3 Brodalumab – Amgen 45
5.8.4 Apremilast – Celgene 46
5.8.5 Secukinumab – Alcon 47
5.9 Heat Map for Pipeline Products 47

6 Market Forecast to 2020 52
6.1 Overview 52
6.2 Global Market 52
6.3 North America 55
6.3.1 Treatment Usage Patterns 55
6.3.2 Annual Cost of Treatment 56
6.3.3 Market Size 58
6.4 Top Five EU Markets 59
6.4.1 Treatment Usage Patterns 59
6.4.2 Annual Cost of Treatment 60
6.4.3 Market Size 61
6.5 Japan 62
6.5.1 Treatment Usage Patterns 62
6.5.2 Annual Cost of Treatment 63
6.5.3 Market Size 64
6.6 Drivers and Barriers for the Systemic Psoriasis Therapeutics Market 65
6.6.1 Drivers 65
6.6.2 Barriers 65

7 Co-development and Licensing deals 67
7.1 Co-development Deals 67
7.1.1 Abbvie Enters into Co-development Agreement with Biotest for Tregalizumab 70
7.1.2 Lycera Enters into Research Agreement with Merck & Co. 70
7.1.3 LEO Pharma Enters into Research Agreement with 4SC Discovery for Inflammatory Skin Diseases 70
7.1.4 Amgen Enters into Co-Development Agreement with AstraZeneca for Five Human Monoclonal Antibodies Including Brodalumab 70
7.2 Licensing Deals 72
7.2.1 Leo Pharma Enters into Licensing Agreement with Virobay for Psoriasis Drug 75
7.2.2 Foamix Enters into Licensing Agreement with Dr. Reddy's Labs 75
7.2.3 Cipher Pharma Enters into Licensing Agreement with IBSA Institut Biochimique for Betesil Patch 75
7.2.4 Phenex Pharma Enters into Licensing Agreement with Janssen Biotech for Retinoid-Acid Receptor-Related Orphan Receptor Gamma t Program 75

8 Appendix 76
8.1 All Pipeline Drugs by Phase 76
8.1.1 Discovery 76
8.1.2 Preclinical 78
8.1.3 Phase I 82
8.1.4 Phase II 84
8.1.5 Phase III 86
8.1.6 Undisclosed 87
8.2 Market Forecasts to 2020 87
8.2.1 Major Developed Markets 87
8.2.2 US 88
8.2.3 UK 88
8.2.4 France 89
8.2.5 Germany 89
8.2.6 Italy 90
8.2.7 Spain 90
8.2.8 Japan 91
8.2.9 Canada 91
8.3 Abbreviations 92
8.4 References 93
8.5 References for Heat Maps 98
8.5.1 Marketed Products 98
8.5.2 Pipeline products 98
8.6 Methodology 100
8.6.1 Secondary Research 100
8.6.2 Therapeutic Landscape 100
8.7 Contact Us 100
8.8 Disclaimer 101

List of Tables


Table 1: Type of Psoriasis 8
Table 2: Systemic Psoriasis Therapeutics Market, Global, Pipeline, Discovery, 2014 76
Table 3: Systemic Psoriasis Therapeutics Market, Global, Pipeline, Preclinical/IND/CTA-filed, 2014 78
Table 4: Systemic Psoriasis Therapeutics Market, Global, Pipeline, Phase I, 2014 82
Table 5: Systemic Psoriasis Therapeutics Market, Global, Phase II, Discovery, 2014 84
Table 6: Systemic Psoriasis Therapeutics Market, Global, Pipeline, Phase III/Pre-registration, 2014 86
Table 7: Systemic Psoriasis Therapeutics Market, Global, Pipeline, Undisclosed, 2014 87
Table 8: Systemic Psoriasis Market Forecast, Global, 2013–2020 87
Table 9: Systemic Psoriasis Market Forecast, US, 2013–2020 88
Table 10: Systemic Psoriasis Market Forecast, UK, 2013–2020 88
Table 11: Systemic Psoriasis Market Forecast, France, 2013–2020 89
Table 12: Systemic Psoriasis Market Forecast, Germany, 2013–2020 89
Table 13: Systemic Psoriasis Market Forecast, Italy, 2013–2020 90
Table 14: Systemic Psoriasis Market Forecast, Spain, 2013–2020 90
Table 15: Systemic Psoriasis Market Forecast, Japan, 2013–2020 91
Table 16: Systemic Psoriasis Market Forecast, Canada, 2013–2020 91
Table 17: Breakdown of ‘Others’ Category 99
Table 18: Breakdown of ‘Combination’ Category 99

List of Figures


Figure 1: Systemic Psoriasis Therapeutics Market, Global, Market Size, 2013–2020 6
Figure 2: Psoriasis Treatment Algorithms 13
Figure 3: Heat Map for Marketed Products 24
Figure 4: Heat Map for Marketed Products (continued) 25
Figure 5: Psoriasis Therapeutics Market, Global, Pipeline, 2013 28
Figure 6: Psoriasis Therapeutics Market, Global, Pipeline by Molecular Target, 2013 30
Figure 7: Psoriasis Therapeutics Market, Global, Pipeline by Molecular Target, 2013 31
Figure 8: Psoriasis Therapeutics Market, Global, Pipeline, Clinical Trial Duration by Molecule Type, (months) 2006–2012 33
Figure 9: Psoriasis Therapeutics Market, Global, Pipeline, Clinical Trial Duration by Molecular Target, (months) 2006–2012 35
Figure 10: Psoriasis Therapeutics Market, Global, Pipeline, Clinical Trial Size by Molecule Type, (participants) 2006–2012 37
Figure 11: Psoriasis Therapeutics Market, Global, Pipeline, Clinical Trial Size by Molecular Target, (participants), 2006–2012 39
Figure 12: Psoriasis Therapeutics Market, Global, Clinical Trial Failure Rate, (%), 2006–2013 40
Figure 13: Psoriasis Therapeutics Market, Global, Frequency of Primary Endpoints Measured in Clinical Trials, (%), 2006–2012 41
Figure 14: Psoriasis Therapeutics Market, Global, Frequency of Secondary Endpoints Measured in Clinical Trials, (%), 2006–2012 42
Figure 15: Heat Map for Pipeline Products 48
Figure 16:Heat Map for Marketed Products 49
Figure 17:Heat Map for Marketed Products (continued) 50
Figure 18: Systemic Psoriasis Therapeutics Market, Global, Treatment Patterns (million), 2013–2020 52
Figure 19: Systemic Psoriasis Therapeutics Market, Global, Market Size ($bn), 2013–2020 54
Figure 20: Systemic Psoriasis Therapeutics Market, North America, Treatment Patterns, 2013–2020 55
Figure 21: Systemic Psoriasis Therapeutics Market, North America, Annual Cost of Treatment ($), 2013–2020 56
Figure 22: Systemic Psoriasis Therapeutics Market, North America, Market Size, 2013–2020 58
Figure 23: Systemic Psoriasis Therapeutics Market, Top Five EU Countries, Treatment Patterns (‘000), 2013–2020 59
Figure 24: Systemic Psoriasis Therapeutics Market, Top Five EU Countries, Annual Cost of Treatment ($), 2013–2020 60
Figure 25: Systemic Psoriasis Therapeutics Market, Top Five EU Countries, Market Size ($m), 2013–2020 61
Figure 26: Systemic Psoriasis Therapeutics Market, Japan, Treatment Patterns (‘000), 2013–2020 62
Figure 27: Systemic Psoriasis Therapeutics Market, Japan, Annual Cost of Treatment ($), 2013–2020 63
Figure 28: Systemic Psoriasis Therapeutics Market, Japan, Market Size ($m), 2013–2020 64
Figure 29: Psoriasis Therapeutics Market, Global, Co-development Deals, 2006–2013 67
Figure 30: Psoriasis Therapeutics Market, Global, Co-development Deals by Phase of Development, Molecule Type and Aggregate Deal Value ($m), 2006–2013 69
Figure 31: Psoriasis Therapeutics Market, Global, Licensing Deals, 2006–2013 72
Figure 32: Psoriasis Therapeutics Market, Licensing Deals by Phase, Molecule Type and Aggregate Deal Value ($m), 2006–2013 73

Upcoming Reports:

Portland Cement Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2019
By - Transparency Market Research
Portland cement is a cementitious building material which is a mixture of clay and limestone. The most common use of this cement is the production of concrete. Portland cement is widely used in construction industry due to its excellent strength, dimensional stability, abrasion resistance, durability and low cost. One of the key drivers for the Portland cement market is the rise in construction activities due to urbanization. In addition, growth in nuclear families, the increasing need of investment in infrastructure and rising disposable income are also expected to augment the...
Linseed Oil Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2014 - 2020
By - Transparency Market Research
Linseed oil is natural oil derived from dry and ripe seeds of flax plant. Linseed oil is also commonly known as flaxseed oil. Linseed oil is obtained from the seeds by pressing as well as by solvent extraction process. Linseed oil has an unique polymerizing property by virtue of which it can polymerize into a solid form. This property of linseed oil is responsible for most of the applications it enjoys. Linseed oil is blended or mixed with other resins, solvents and oils in order to be used as pigment binder in paints and coatings, as varnish and impregnator in wood finishing, and as an...
Luxury Hotels Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2019
By - Transparency Market Research
Luxury Hotels market is one of the fastest growing sectors in the consumer retail segment. The growth in the travel and tourism industry is majorly fuelling the growth of luxury hotel markets. Increasing number of high net worth individuals (HNWIs) globally, primarily in the BRIC countries, the economic growth, the rising disposable income of upper middle class, the increasing dominance of corporate sector on national and international economies and the emerging corporate culture are some of the factors driving the global luxury travel market, which in turn, is driving the growth in the...

Research Assistance

We will be happy to help you find what you need.
Please call us or write us:

866-997-4948 (Us-Canada Toll Free)
Tel: +1-518-618-1030
Email: sales@researchmoz.us
Select License type:

Share this report

Related News

Western Africa economies hit by Ebola travel ban
Aug 28, 2014  
With over 1,400 people dead due to the fatal Ebola outbreak in African countries, travel services have either banned or limited operations to the western region, severely hitting economies of the area. Budgetary resources are being utilized rapidly and economic growth has dropped by 4% as international projects and trips have been cancelled. Transport companies have cut off the region...
Fonterra Ties Up With Beingmate to Tap into China’s Baby Food Market
Aug 28, 2014  
Fonterra Co-Operative Group Ltd. will partner with Beingmate Group Co, China’s biggest infant formula manufacturer to increase its reach in the Chinese market. The New Zealand-based company makes this move with the intent to grab a bigger market share in China after it suffered many setbacks in the food-safety scandal last year.   This partnership will also help Beingmate...
Warren Buffet Helps Burger King with Tim Horton Deal
Aug 27, 2014  
Renowned investor Warren Buffet plans to finance Burger King Worldwide Inc.’s acquisition of Tim Hortons Inc., the Canadian coffee chain. Berkshire Hathaway Inc., Warren Buffet’s firm will invest through preferred shares, it is speculated. Nearly 25% of the deal’s financing would be handled by Berkshire. The precise aim for Warren Buffet’s participation is yet...
Anti-UAW Workers to Form Another Union at Volkswagen Plant
Aug 27, 2014  
Employees at the Chattanooga plant of Volkswagen AG are trying to form a union of company’s salaried and hourly workers, as a means to counter the United Auto Workers Local 42 union that was established last month.  The new union is expected to force Volkswagen in rethinking and holding another vote to determine which union is favored by hourly employees. UAV had earlier...
Fairchild Axing 15% of its Workforce with Multiple Plant Closures
Aug 27, 2014  
American semiconductor manufacturer Fairchild has said that it will be laying off nearly 15% of its global workforce following the closure of its facilities in Malaysia, Utah, and Korea. The company will cease the production of five-inch silicon from its plant in Bucheon, Korea. It will also scale down its capacity to produce six-inch wafers. The company will bring these closures into effect...