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Secondary Progressive Multiple Sclerosis (SPMS) - Pipeline Review, H1 2015

Published By :

Global Markets Direct

Published Date : Jan 2015

Category :

Diseases & Conditions

No. of Pages : 87 Pages


Global Markets Directs, Secondary Progressive Multiple Sclerosis (SPMS) Pipeline Review, H1 2015, provides an overview of the Secondary Progressive Multiple Sclerosis (SPMS)s therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Secondary Progressive Multiple Sclerosis (SPMS), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Secondary Progressive Multiple Sclerosis (SPMS) and special features on late-stage and discontinued projects.

Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Scope

  • The report provides a snapshot of the global therapeutic landscape of Secondary Progressive Multiple Sclerosis (SPMS)
  • The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in the therapeutics development for Secondary Progressive Multiple Sclerosis (SPMS) and enlists all their major and minor projects
  • The report summarizes all the dormant and discontinued pipeline projects 
  • A review of the Secondary Progressive Multiple Sclerosis (SPMS) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • A detailed assessment of monotherapy and combination therapy pipeline projects
  • Coverage of the Secondary Progressive Multiple Sclerosis (SPMS) pipeline on the basis of target, MoA, route of administration and molecule type
  • Latest news and deals relating related to pipeline products

Reasons to buy

  • Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Identify and understand important and diverse types of therapeutics under development for Secondary Progressive Multiple Sclerosis (SPMS)
  • Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline
  • Devise corrective measures for pipeline projects by understanding Secondary Progressive Multiple Sclerosis (SPMS) pipeline depth and focus of Indication therapeutics
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
  • Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents 2
List of Tables 5
List of Figures 5

Introduction 6
Global Markets Direct Report Coverage 6
Secondary Progressive Multiple Sclerosis (SPMS) Overview 7
Therapeutics Development 8
Pipeline Products for Secondary Progressive Multiple Sclerosis (SPMS) Overview 8
Pipeline Products for Secondary Progressive Multiple Sclerosis (SPMS) Comparative Analysis 9
Secondary Progressive Multiple Sclerosis (SPMS) Therapeutics under Development by Companies 10
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline Products Glance 12
Late Stage Products 12
Clinical Stage Products 13
Early Stage Products 14
Secondary Progressive Multiple Sclerosis (SPMS) Products under Development by Companies 15
Secondary Progressive Multiple Sclerosis (SPMS) Companies Involved in Therapeutics Development 16
AB Science 16
Biogen Idec Inc. 17
Daval International Ltd. 18
Genzyme Corporation 19
Glialogix, Inc. 20
Immune Response BioPharma, Inc. 21
Innate Therapeutics Limited 22
Kyorin Pharmaceutical Co., Ltd. 23
MedDay 24
Novartis AG 25
Opexa Therapeutics, Inc. 26
Secondary Progressive Multiple Sclerosis (SPMS) Therapeutics Assessment 27
Assessment by Monotherapy Products 27
Assessment by Target 28
Assessment by Mechanism of Action 30
Assessment by Route of Administration 32
Assessment by Molecule Type 34
Drug Profiles 36
Aimspro - Drug Profile 36
Product Description 36
Mechanism of Action 36
R&D Progress 36
BIIB-033 - Drug Profile 38
Product Description 38
Mechanism of Action 38
R&D Progress 38
DC-TAB - Drug Profile 40
Product Description 40
Mechanism of Action 40
R&D Progress 40
GLX-1112 - Drug Profile 41
Product Description 41
Mechanism of Action 41
R&D Progress 41
GZ-402668 - Drug Profile 42
Product Description 42
Mechanism of Action 42
R&D Progress 42
ibudilast - Drug Profile 43
Product Description 43
Mechanism of Action 43
R&D Progress 43
imilecleucel-t - Drug Profile 45
Product Description 45
Mechanism of Action 45
R&D Progress 45
interferon beta-1b - Drug Profile 47
Product Description 47
Mechanism of Action 47
R&D Progress 47
IR-902 - Drug Profile 48
Product Description 48
Mechanism of Action 48
R&D Progress 48
masitinib - Drug Profile 49
Product Description 49
Mechanism of Action 49
R&D Progress 49
MD-1003 - Drug Profile 52
Product Description 52
Mechanism of Action 52
R&D Progress 52
MIS-416 - Drug Profile 53
Product Description 53
Mechanism of Action 53
R&D Progress 53
natalizumab - Drug Profile 56
Product Description 56
Mechanism of Action 56
R&D Progress 56
siponimod - Drug Profile 58
Product Description 58
Mechanism of Action 58
R&D Progress 58
Small Molecules for Multiple Sclerosis - Drug Profile 60
Product Description 60
Mechanism of Action 60
R&D Progress 60
Secondary Progressive Multiple Sclerosis (SPMS) Recent Pipeline Updates 61
Secondary Progressive Multiple Sclerosis (SPMS) Discontinued Products 78
Secondary Progressive Multiple Sclerosis (SPMS) Product Development Milestones 79
Featured News & Press Releases 79
Oct 07, 2014: Update on Innates Phase 2B trial and other recent activities 79
Aug 19, 2014: Innates Phase 2B clinical trial on SPMS to start recruiting patients following Perth site obtaining ethics approval 79
Jun 20, 2014: Update on Phase 2B Trial of MIS416 in Patients with Secondary Progressive Multiple Sclerosis 80
Jun 18, 2014: Compassionate Use Programme Update 80
May 13, 2014: Opexa Reaches Enrollment Target in Phase IIb Trial of Personalized Immunotherapy for Secondary Progressive Multiple Sclerosis 81
Apr 15, 2014: Innate Immunotherapeutics confirms Phase 2B trial on track and on budget 82
Mar 11, 2014: Innate Immunotherapeutics receives EU patent protection for use of MIS416 to treat or prevent radiation injury 83
Feb 03, 2014: Dr Larry Steinman, renowned multiple sclerosis specialist at Stanford University, endorses newly published MIS416 therapy validation in animal studies 83
Dec 16, 2013: Opexa Therapeutics Provides MS Trial Enrollment Update; 70% of Patients Enrolled 84
Nov 13, 2012: Opexa Receives Clinical Trial Approval From Health Canada For New T-Cell Therapy, Tcelna 85

Appendix 86
Methodology 86
Coverage 86
Secondary Research 86
Primary Research 86
Expert Panel Validation 86
Contact Us 87
Disclaimer 87

List of Table


Number of Products under Development for Secondary Progressive Multiple Sclerosis (SPMS), H1 2015 8
Number of Products under Development for Secondary Progressive Multiple Sclerosis (SPMS) Comparative Analysis, H1 2015 9
Number of Products under Development by Companies, H1 2015 11
Comparative Analysis by Late Stage Development, H1 2015 12
Comparative Analysis by Clinical Stage Development, H1 2015 13
Comparative Analysis by Early Stage Development, H1 2015 14
Products under Development by Companies, H1 2015 15
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by AB Science, H1 2015 16
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Biogen Idec Inc., H1 2015 17
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Daval International Ltd., H1 2015 18
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Genzyme Corporation, H1 2015 19
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Glialogix, Inc., H1 2015 20
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Immune Response BioPharma, Inc., H1 2015 21
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Innate Therapeutics Limited, H1 2015 22
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Kyorin Pharmaceutical Co., Ltd., H1 2015 23
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by MedDay, H1 2015 24
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Novartis AG, H1 2015 25
Secondary Progressive Multiple Sclerosis (SPMS) Pipeline by Opexa Therapeutics, Inc., H1 2015 26
Assessment by Monotherapy Products, H1 2015 27
Number of Products by Stage and Target, H1 2015 29
Number of Products by Stage and Mechanism of Action, H1 2015 31
Number of Products by Stage and Route of Administration, H1 2015 33
Number of Products by Stage and Molecule Type, H1 2015 35
Secondary Progressive Multiple Sclerosis (SPMS) Therapeutics Recent Pipeline Updates, H1 2015 61
Secondary Progressive Multiple Sclerosis (SPMS) Discontinued Products, H1 2015 78

List of Chart


Number of Products under Development for Secondary Progressive Multiple Sclerosis (SPMS), H1 2015 8
Number of Products under Development for Secondary Progressive Multiple Sclerosis (SPMS) Comparative Analysis, H1 2015 9
Number of Products under Development by Companies, H1 2015 10
Comparative Analysis by Clinical Stage Development, H1 2015 13
Assessment by Monotherapy Products, H1 2015 27
Number of Products by Top 10 Targets, H1 2015 28
Number of Products by Stage and Top 10 Targets, H1 2015 28
Number of Products by Top 10 Mechanism of Actions, H1 2015 30
Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 30
Number of Products by Top 10 Routes of Administration, H1 2015 32
Number of Products by Stage and Top 10 Routes of Administration, H1 2015 33
Number of Products by Top 10 Molecule Types, H1 2015 34
Number of Products by Stage and Top 10 Molecule Types, H1 2015 35

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