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Invokana (Type 2 Diabetes) - Forecast and Market Analysis to 2022

Published By :

GlobalData

Published Date : Jul 2013

Category :

Metabolic Disorders

No. of Pages : 47 Pages


GlobalData has released its new report, Invokana (Type 2 Diabetes) Forecast and Market Analysis to 2022. The type 2 diabetes market is mature and crowded with inexpensive generics. Despite being marked by a late-stage pipeline filled with me-too drugs, this market will undergo substantial growth between 2012 and 2022, more than doubling over this period. The main drivers of growth will be the dramatic increase in disease prevalence and physicians efforts to delay disease progression and reduce the costly burden of diabetic complications through the use of combination therapies and novel branded drugs.

On March 29, 2013, the FDA approved Johnson & Johnsons Invokana (canagliflozin), the first-to-the-US-market SGLT-2 inhibitor for treatment of type 2 diabetes. Invokana is in-licensed from Mitsubishi Tanabe Pharma. Invokanas mechanism of action employs the inhibition of SGLT-2, a low-affinity, high-capacity glucose cotransporter that is almost exclusively expressed in the kidney cortex. Inhibition of SGLT-2 has been shown to block the bodys capacity to reabsorb glucose via the kidney, leading to glucose elimination in the urine and a reduction in blood glucose levels.

Scope

  • Overview of type 2 diabetes, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
  • Detailed information on Invokana including product description, safety and efficacy profiles as well as a SWOT analysis.
  • Sales forecast for Invokana for the top ten countries from 2012 to 2022.
  • Sales information covered for the US, France, Germany, Italy, Spain, the UK, Japan, Brazil, India and China.

Reasons to buy

  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of the competition by understanding the changing competitive landscape for type 2 diabetes
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of Invokana performance
  • Obtain sales forecast for Invokana from 2012-2022 in top ten countries (the US, France, Germany, Italy, Spain, the UK, Japan, Brazil, India and China)
Table of Contents

1 Table of Contents
1 Table of Contents 6
1.1 List of Tables 8
1.2 List of Figures 8

2 Introduction 9
2.1 Catalyst 9
2.2 Related Reports 10

3 Disease Overview 13
3.1 Etiology and Pathophysiology 13
3.1.1 Etiology 13
3.1.2 Pathophysiology 14
3.1.3 Prognosis 15
3.1.4 Quality of Life 16
3.2 Symptoms 16

4 Disease Management 18
4.1 Treatment Overview 18
4.1.1 Diagnosis and Referrals 18
4.1.2 Treatment Guidelines 19

5 Competitive Assessment 25
5.1 Overview 25
5.2 Strategic Competitor Assessment 26

6 Invokana (canagliflozin) 28
6.1 Overview 28
6.2 Efficacy 29
6.3 Safety 30
6.4 SWOT Analysis 31
6.5 Forecast 31

7 Appendix 33
7.1 Bibliography 33
7.2 Abbreviations 37
7.3 Methodology 38
7.4 Forecasting Methodology 38
7.4.1 Diagnosed Type 2 Patients 38
7.4.2 Percent Drug-Treated Patients 39
7.4.3 Drugs Included in Each Therapeutic Class 39
7.4.4 Launch and Patent Expiry Dates 40
7.4.5 General Pricing Assumptions 40
7.4.6 Individual Drug Assumptions 41
7.4.7 Generic Erosion 41
7.5 Physicians and Specialists Included in this Study 42
7.6 About the Authors 44
7.6.1 Analyst II - CVMD 44
7.6.2 Therapy Director - CVMD and Infectious Disease 44
7.6.3 Global Head of Healthcare 45
7.7 About GlobalData 46
7.8 Disclaimer 46

List of Table


Table 1: Symptoms of Type 2 Diabetes 17
Table 2: Diagnostic Tests and Typical Criteria for Type 2 Diabetes 18
Table 3: Treatment Guidelines for Type 2 Diabetes 20
Table 4: Most-Prescribed Drugs (Following Metformin and Sulfonylureas) for Type 2 Diabetes by Class in the Global Markets, 2012 23
Table 5: Leading Branded Treatments for Type 2 Diabetes, 2012 27
Table 6: Product Profile - Invokana 29
Table 7: Invokana SWOT Analysis, 2012 31
Table 8: Global Sales Forecasts ($) for Invokana, 2012-2022 32
Table 9: Key Launch Dates 40
Table 10: Key Patent Expiries 40
Table 11: Number of High-Prescribing Physicians Surveyed 43

List of Chart


Figure 1: ADA/EASD General Recommendations for Antihyperglycemic Therapy 22

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