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Intermittent Claudication - Pipeline Review, H1 2015

Published By :

Global Markets Direct

Published Date : Jan 2015

Category :

Diseases & Conditions

No. of Pages : 74 Pages


Global Markets Directs, Intermittent Claudication Pipeline Review, H1 2015, provides an overview of the Intermittent Claudications therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Intermittent Claudication, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Intermittent Claudication and special features on late-stage and discontinued projects.

Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Scope

  • The report provides a snapshot of the global therapeutic landscape of Intermittent Claudication
  • The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in the therapeutics development for Intermittent Claudication and enlists all their major and minor projects
  • The report summarizes all the dormant and discontinued pipeline projects 
  • A review of the Intermittent Claudication products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • A detailed assessment of monotherapy and combination therapy pipeline projects
  • Coverage of the Intermittent Claudication pipeline on the basis of target, MoA, route of administration and molecule type
  • Latest news and deals relating related to pipeline products

Reasons to buy

  • Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Identify and understand important and diverse types of therapeutics under development for Intermittent Claudication
  • Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline
  • Devise corrective measures for pipeline projects by understanding Intermittent Claudication pipeline depth and focus of Indication therapeutics
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
  • Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents 2
List of Tables 4
List of Figures 5

Introduction 6
Global Markets Direct Report Coverage 6
Intermittent Claudication Overview 7
Therapeutics Development 8
Pipeline Products for Intermittent Claudication - Overview 8
Pipeline Products for Intermittent Claudication - Comparative Analysis 9
Intermittent Claudication - Therapeutics under Development by Companies 10
Intermittent Claudication - Pipeline Products Glance 11
Clinical Stage Products 11
Early Stage Products 12
Intermittent Claudication - Products under Development by Companies 13
Intermittent Claudication - Companies Involved in Therapeutics Development 14
Cytokinetics, Inc. 14
DNAVEC Corporation 15
Genovate Biotechnology Co., LTD. 16
Kowa Company, Ltd. 17
LTT Bio-Pharma Co., Ltd. 18
Nuo Therapeutics, Inc. 19
Pluristem Therapeutics Inc. 20
Rigel Pharmaceuticals, Inc. 21
Taisho Toyama Pharmaceutical Co., Ltd. 22
Intermittent Claudication - Therapeutics Assessment 23
Assessment by Monotherapy Products 23
Assessment by Target 24
Assessment by Mechanism of Action 26
Assessment by Route of Administration 28
Assessment by Molecule Type 30
Drug Profiles 32
ALD-301 - Drug Profile 32
Product Description 32
Mechanism of Action 32
R&D Progress 32
alprostadil - Drug Profile 34
Product Description 34
Mechanism of Action 34
R&D Progress 34
cilostazol CR - Drug Profile 35
Product Description 35
Mechanism of Action 35
R&D Progress 35
CK-2066260 - Drug Profile 36
Product Description 36
Mechanism of Action 36
R&D Progress 36
DVC1-0101 - Drug Profile 38
Product Description 38
Mechanism of Action 38
R&D Progress 38
ecraprost - Drug Profile 39
Product Description 39
Mechanism of Action 39
R&D Progress 39
K-134 - Drug Profile 41
Product Description 41
Mechanism of Action 41
R&D Progress 41
LT-0101 - Drug Profile 42
Product Description 42
Mechanism of Action 42
R&D Progress 42
R-118 - Drug Profile 43
Product Description 43
Mechanism of Action 43
R&D Progress 43
Stem Cell Therapy for Cardiovascular Diseases - Drug Profile 44
Product Description 44
Mechanism of Action 44
R&D Progress 44
tirasemtiv - Drug Profile 46
Product Description 46
Mechanism of Action 46
R&D Progress 46
Intermittent Claudication - Recent Pipeline Updates 53
Intermittent Claudication - Dormant Projects 65
Intermittent Claudication - Discontinued Products 66
Intermittent Claudication - Product Development Milestones 67
Featured News & Press Releases 67
Mar 06, 2014: Rigel Announces Publication of R118 AMPK Activator Research 67
Nov 13, 2013: Pluristem Receives Regulatory Approval to Extend Its Phase II Study of PLX-PAD Cells in the Treatment of Intermittent Claudication to South Korea 68
Oct 02, 2013: Pluristem Receives Israeli Ministry of Health Approval to Expand Its Phase II Clinical Trial in Intermittent Claudication to Israel 68
Sep 16, 2013: FDA Lifts Clinical Hold of Pluristem's Phase II Intermittent Claudication Study 69
Jul 08, 2013: Pluristem's South Korean Partner Files IND With Korean FDA for PLX Cells 69
Jun 04, 2013: Pluristem To Receive Clinical-hold Notice From FDA For US Phase II Intermittent Claudication Study 69
Jan 15, 2013: Pluristem Receives Approval To Expand Phase II Clinical Trial In Intermittent Claudication To Germany 70
Aug 23, 2012: Pluristem Commences Phase II Clinical Trial For Intermittent Claudication Using PLX Cells 70
Aug 13, 2012: Pluristem Moves Intermittent Claudication Indication Forward in Germany Through Collaboration With Cato Research 71
Jul 18, 2012: Pluristem Partners With CPC Clinical Research For Peripheral Artery Disease Study 71

Appendix 73
Methodology 73
Coverage 73
Secondary Research 73
Primary Research 73
Expert Panel Validation 73
Contact Us 74
Disclaimer 74

List of Table


Number of Products under Development for Intermittent Claudication, H1 2015 8
Number of Products under Development for Intermittent Claudication - Comparative Analysis, H1 2015 9
Number of Products under Development by Companies, H1 2015 10
Comparative Analysis by Clinical Stage Development, H1 2015 11
Comparative Analysis by Early Stage Development, H1 2015 12
Products under Development by Companies, H1 2015 13
Intermittent Claudication - Pipeline by Cytokinetics, Inc., H1 2015 14
Intermittent Claudication - Pipeline by DNAVEC Corporation, H1 2015 15
Intermittent Claudication - Pipeline by Genovate Biotechnology Co., LTD., H1 2015 16
Intermittent Claudication - Pipeline by Kowa Company, Ltd., H1 2015 17
Intermittent Claudication - Pipeline by LTT Bio-Pharma Co., Ltd., H1 2015 18
Intermittent Claudication - Pipeline by Nuo Therapeutics, Inc., H1 2015 19
Intermittent Claudication - Pipeline by Pluristem Therapeutics Inc., H1 2015 20
Intermittent Claudication - Pipeline by Rigel Pharmaceuticals, Inc., H1 2015 21
Intermittent Claudication - Pipeline by Taisho Toyama Pharmaceutical Co., Ltd., H1 2015 22
Assessment by Monotherapy Products, H1 2015 23
Number of Products by Stage and Target, H1 2015 25
Number of Products by Stage and Mechanism of Action, H1 2015 27
Number of Products by Stage and Route of Administration, H1 2015 29
Number of Products by Stage and Molecule Type, H1 2015 31
Intermittent Claudication Therapeutics - Recent Pipeline Updates, H1 2015 53
Intermittent Claudication - Dormant Projects, H1 2015 65
Intermittent Claudication - Discontinued Products, H1 2015 66

List of Chart


Number of Products under Development for Intermittent Claudication, H1 2015 8
Number of Products under Development for Intermittent Claudication - Comparative Analysis, H1 2015 9
Number of Products under Development by Companies, H1 2015 10
Comparative Analysis by Clinical Stage Development, H1 2015 11
Comparative Analysis by Early Stage Products, H1 2015 12
Assessment by Monotherapy Products, H1 2015 23
Number of Products by Top 10 Targets, H1 2015 24
Number of Products by Stage and Top 10 Targets, H1 2015 25
Number of Products by Top 10 Mechanism of Actions, H1 2015 26
Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 27
Number of Products by Top 10 Routes of Administration, H1 2015 28
Number of Products by Stage and Top 10 Routes of Administration, H1 2015 29
Number of Products by Top 10 Molecule Types, H1 2015 30
Number of Products by Stage and Top 10 Molecule Types, H1 2015 31

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