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Infectious agent: Prions

Published By :

RI Technologies

Published Date : Apr 2014

Category :

Agriculture

No. of Pages : 574 Pages

This market insight report on Prions gives an insight into the global market for Prion Deactivation technologies, Post Mortem Testing for BSE and Prion Reduction Filters. The Prion related products include BSE detection test Kits, Deactivation/Inactivation technologies, Reagents and Services. The study includes estimations and predictions for the global BSE Post Mortem Testing Market. The market is also analyzed by geographic regions encompassing North America, Europe, Japan and Rest of World. Business profiles of 25 major companies are discussed in the report. The report serves as a complete guide to global Prion Detection, Reduction and Inactivation Market covering more than 120 companies that are engaged in research for development of antemortem BSE and CJD test kits, development and supply of BSE Test kits and development of prion Reduction Filters. Information related to recent product releases, product developments, partnerships, collaborations, and mergers and acquisitions is also covered in the report.

The reason that prions are gaining importance is because they cause certain neurodegenerative diseases in animals and humans, which are incurable as of date. Creutzfeldt-Jakob disease in humans and Bovine spongiform encephalopathy (mad cow disease) are two such examples. The infected person or animal dies within months or even weeks after the symptoms start surfacing. European Union has imposed very stringent measures for controlling TSE infections in domestic animals. Slaughterhouses in EU are required to test for BSE even the healthy cattle that are 30 years or more of age. From the cattle that die on the farm, those that are 24 months or more of age have to be tested for BSE. Out of the cattle being sent for rendering, those that are 24 months and above of age, are to be tested for presence of BSE infection before rendering. Apart from these, any cattle, which displays any physical symptom of BSE, has to be tested, irrespective of the age thus increasing the market for BSE testing in Europe.Only 10% of cows are tested for BSE in the US. The new US policy is a sharp contrast to the measures taken by countries such as Japan, where 100 percent of cows are tested for BSE infection at the time of slaughtering, to ensure that the meat is safe for human consumption. Japan insists that all the cattle be tested at the time of slaughter.
Table of Content

1. SCOPE AND METHODOLOGY

2. REPORT SYNOPSIS
2.1 Prions
Definition
Introduction
Exhibit 1. Mammalian Agents of Spongiform Encephalopathies, ICTVdb Code,
Disease Name, Natural Host, Prion Name and PrP Iso Form
General Definitions
Genetic Disorder
Sporadic Disease
Itarogenic Disease
History of BSE
Animal Feed
Animal Feed Regulations
Concern for Quality of Feed Ingredients with Increase in BSE around the World
Eurofins Forms Strategic Alliance with VLA in UK to Maintain Feed Safety
Plan on Ban of certain Cattle Material from Medical Products to
Protect Against BSE
New Theory Suggests the Origin of Mad Cow Disease to be from Human Beings
Role of WHO in TSE Control
Role of OIE
2.2 Prions - Global Market Analysis
Exhibit 2. Prion Deactivation Technologies - Global Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
Exhibit 3. Prion Reduction Filters - Global Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
Exhibit 4. BSE Post Mortem Testing - Global Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
Exhibit 5. List of Global Major Prions Companies

3. MARKET DYNAMICS
3.1 World Cattle Demographics
Exhibit 6. World Cattle Population (2000-2006) – By Geographic Regions for North America, Europe, Japan and Rest of World in Million Head (Graphical Representation Included)
3.2 Market Overview
3.3 Global Prion Deactivation Technologies Market
Exhibit 7. Prion Deactivation Technologies - Global Market Estimations & Predictions (2005 - 2020) by Geographic Regions for Europe, Japan, North America and Rest of World in US$ Million (Graphical Representation Included)
Exhibit 8. Prion Deactivation Technologies - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for Europe, Japan, North America and Rest of World (Graphical Representation Included)
Exhibit 9. List of Global Prion Deactivation Technologies Companies
3.4 North American Prion Deactivation Technologies Market
Exhibit 10. Prion Deactivation Technologies - North American Market Estimations & Predictions (2005 - 2020) by Geographic Region for Canada and United States in US$ Million (Graphical Representation Included)
Exhibit 11. Prion Deactivation Technologies - North American Market Shares (2010, 2015 & 2020) by Geographic Region for Canada and United States (Graphical Representation Included)
3.4 (I) United States Prion Deactivation Technologies Market
3.4 (II) Canadian Prion Deactivation Technologies Market
3.5 European Prion Deactivation Technologies Market
Exhibit 12. Prion Deactivation Technologies - European Market Estimations & Predictions (2005 - 2020) by Geographic Region for United Kingdom, France, Ireland, Portugal, Switzerland, Germany and Rest of Europe in US$ Million (Graphical Representation Included)
Exhibit 13. Prion Deactivation Technology - European Market Shares (2010, 2015 & 2020) by Geographic Region for United Kingdom, France, Ireland, Portugal, Switzerland, Germany and Rest of Europe
3.5 (I) United Kingdom Prion Deactivation Technologies Market
3.5 (II) French Prion Deactivation Technologies Market
3.5 (III) Irish Prion Deactivation Technologies Market
3.5 (IV) Portuguese Prion Deactivation Technologies Market
3.5 (V) Swiss Prion Deactivation Technologies Market
3.5 (VI) German Prion Deactivation Technologies Market
3.6 Japanese Prion Deactivation Technologies Market
Exhibit 14. Prion Deactivation Technologies - Japanese Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
3.7 Rest of World Prion Deactivation Technologies Market
Exhibit 15. Prion Deactivation Technologies – Rest of World Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
3.10 Global Prion Reduction Filters Market
Exhibit 16. Prion Reduction Filters - Global Market Estimations & Predictions (2005 - 2020) by Geographic Regions for Europe, North America, Japan and Rest of World in US$ Million (Graphical Representation Included)
Exhibit 17. Prion Reduction Filters - Global Market Shares (2010, 2015 & 2020) by Geographic Region for Europe, North America, Japan and Rest of World
Exhibit 18. List of Global Major Prion Reduction Filter Companies
3.11 North American Prion Reduction Filters Market
Exhibit 19. Prion Reduction Filters - North American Market Estimations & Predictions (2005 - 2020) by Geographic Region for Canada and United States in US$ Million (Graphical Representation Included)
Exhibit 20. Prion Reduction Filters - North American Market Shares (2010, 2015 & 2020) by Geographic Region for Canada and United States (Graphical Representation Included)
3.11 (I) United States Prion Reduction Filters Market
3.11 (II) Canadian Prion Reduction Filters Market
3.12 European Prion Reduction Filters Market
Exhibit 21. Prion Reduction Filters - European Market Estimations & Predictions (2005 - 2020) by Geographic Regions for United Kingdom, France, Ireland, Portugal, Switzerland, Germany and Rest of Europe in US$ Million
(Graphical Representation Included)
Exhibit 22. Prion Reduction Filters - European Market Shares (2010, 2015 & 2020) by Geographic Region for United Kingdom, France, Ireland, Portugal, Switzerland, Germany and Rest of Europe
3.12 (I) United Kingdom Prion Reduction Filters Market
3.12 (II) French Prion Reduction Filters Market
3.12 (III) Irish Prion Reduction Filters Market
3.12 (IV) Portuguese Prion Reduction Filters Market
3.12 (V) Swiss Prion Reduction Filters Market
3.12 (VI) German Prion Reduction Filters Market
3.13 Japanese Prion Reduction Filters Market
Exhibit 23. Prion Reduction Filters - Japanese Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
3.14 Rest of World Prion Reduction Filters Market
Exhibit 24. Prion Reduction Filters - Rest of World Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
3.15 Global BSE Post Mortem Testing Market
Exhibit 25. BSE Post Mortem Testing - Global Market Estimations & Predictions (2005 - 2020) by Geographic Regions for Europe, North America, Japan and Rest of World in US$ Million (Graphical Representation Included)
Exhibit 26. BSE Post Mortem Testing - Global Market Shares (2010, 2015 & 2020) by Geographic Region for Europe, North America, Japan and Rest of World
Exhibit 27. List of Global BSE Post Mortem Testing Companies
3.16 North American BSE Post Mortem Testing Market
Exhibit 28. BSE Post Mortem Testing - North American Market Estimations & Predictions (2005 - 2020) by Geographic Region for Canada and United States in US$ Million (Graphical Representation Included)
Exhibit 29. BSE Post Mortem Testing - North American Market Shares (2010, 2015 & 2020) by Geographic Region for Canada and United States (Graphical Representation Included)
US Allocation of Funds for Food Safety and BSE Research
Harmonization of BSE Management Policies by United States, Canada, and Mexico
3.16 (I) United States BSE Post Mortem Testing Market
3.16 (II) Canadian BSE Post Mortem Testing Market
3.17 European BSE Post Mortem Testing Market
Exhibit 30. BSE Post Mortem Testing - European Market Estimations & Predictions (2005 - 2020) by Geographic Regions for United Kingdom, France, Ireland, Portugal, Switzerland, Germany and Rest of Europe in US$ Million (Graphical Representation Included)
Exhibit 31. BSE Post Mortem Testing - European Market Shares (2010, 2015 & 2020) by Geographic Region for United Kingdom, France, Ireland, Portugal, Switzerland, Germany and Rest of Europe
Exhibit 32. Number of Confirmed BSE cases in Europe by Geographic Regions: United Kingdom, France, Ireland, Portugal, Switzerland, Germany (1987 - 2012)
3.17 (I) European Cattle Demographics
Exhibit 33. Cattle – European Population (2000-2010) by Countries for UK, France, Ireland, Portugal, Switzerland, Germany and Rest of Europe in Million Head (Graphical Representation Included)
European Policies on BSE
EU Commission’s Latest Proposal Reduces BSE Testing Costs
3.17 (II) United Kingdom BSE Post Mortem Testing Market
BSE Cases in the United Kingdom
Measures Taken by United Kingdom to Control BSE
3.17 (III) French BSE Post Mortem Testing Market
3.17 (IV) Irish BSE Post Mortem Testing Market
3.17 (V) Portuguese BSE Post Mortem Testing Market
3.17 (VI) Swiss BSE Post Mortem Testing Market
Swiss Beef Industry Awarded for Managing BSE
3.17 (VII) German BSE Post Mortem Testing Market
Germany to Modify BSE Testing Regulations
The Netherlands
New Case of Mad Cow Disease Reported in the Netherlands
Slovenia
Slovenian Authorities Confirm BSE Case Findings
Austria
August 2005, Third Case of Mad Cow Reported in Austria
3.18 Japanese BSE Post Mortem Testing Market
Exhibit 34. BSE Post Mortem Testing - Japanese Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
Exhibit 35. Number of Confirmed BSE Cases in Japan (Graphical Representation Included)
BSE Cases Reported in Japan
Health Ministry Bans Blood Donations in Japan
A New Amendment Proposed by USDA on Import of Boneless Beef from Japan
Japan Re-enforces US Beef Ban
3.19 Rest of World BSE Post Mortem Testing Market
Exhibit 36. BSE Post Mortem Testing - Rest of World Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
3.20 Major Companies in Prions Market
Abbott Laboratories (USA)
Altegen, Inc. (USA)
Beckman Coulter, Inc. (USA)
Bio-Rad Laboratories, Inc. (USA)
Chronix Biomedical GmbH (Germany)
Clinical Data, Inc. (USA)
Covance, Inc. (USA)
More………
3.21 Major Activities in Prions Industry
ASP Sterrad Technology Approved by AFSSAPS for Total Inactivation of Prions
Neogen Completes Acquisition of GeenSeek Inc.
ProMetic Signs Marketing Agreement with Abraxis BioScience
BTG plc Takes Over Protherics PLC
Gambro BCT Changes Corporate Identity to CaridianBCT
More….
3.22 Beef Market – An Overview
US Beef Consumption
Exhibit 37. Beef Consumption – United States (2002-2011) in Billion Pounds (Graphical Representation Included)
US Beef Production
Exhibit 38. Beef Production – United States Commercial Carcass Weight (2002-2011) in Billion Pounds (Graphical Representation Included)
US Beef Exports
Exhibit 39. Beef Exports – United States Commercial Carcass Weight (2002-2011) in Million Pounds (Graphical Representation Included)
Exhibit 40. Beef Exports – United States (2002-2011) in US$ Million (Graphical Representation Included)
South Korea Resumes US Beef Imports
US Packers Consider Re-entry into South Korean Beef Market
Mexico to Resume Trade with US Dairy Heifers
BSE Cases Reported in the US
Only 10 Percent of Cows to be tested for BSE in the US from August
US Lifts Ban on Aged Cattle Imports from Canada
Canadian Beef Markets
Exhibit 41. Beef Products - Canadian Exports (2002-2011) for Live Animal and Beef CAN$ Million (Graphical Representation Included)
Exhibit 42. United States Cattle – Imports from Canada and Other Countries (2002-2011) in Heads (Graphical Representation Included)
New Incidence of BSE in Canada Reignites US Import Struggle
Exhibit 43. United States Beef and Veal –Imports from Canada and Other Countries (2002-2011) in Billion Pounds (Graphical Representation Included)
Bison in Demand after BSE Crisis Confirmed BSE Cases in North America
Exhibit 44. Number of Confirmed BSE cases in United States and Canada (2003-2012)
1997 Canada Feed Ban
Prevalence of BSE in Canada
$39.8 Million to Alberta for New Feed Regulation Implementation
New Regulations for Animal Feed in Canada
Beef Industry in Canada Granted Class Action Suit of Compensation
Safer Designation for Canadian Cattle from World Organization for Animal Health
New Network of Excellence Centers to Study Prion Diseases
Control Measures to Prevent Spread of BSE
Control Measures to Prevent Transmission of BSE to Human
Canada Amends BSE Infection Control Regulations for US Imports
Exhibit 45. BSE Cases Diagnosed in North America (1993-2007)
3.23 Prions – Market Outlook

4. PRODUCT /TECHNOLOGY RESEARCH
4.1 Introduction
History
Prions Formation
Structure and Organization of Prions
Special Characteristics of Infectious Proteins
Isoforms
PrPC
PrPSc
PrP’s Role in Long-Term Memory
Hypothesis
Characteristics of Prions
Exhibit 46. Comparison of General Characteristics of Classic Virus and Prions
Prion Biosynthesis
Prions Replication
Prion Strains
Species Barrier
Diseases Caused by Prions
Exhibit 47. Diseases caused by Prions in Animals
Characteristics of Transmissible Spongiform Encephalopathy (TSE)
Treatment of TSEs
Transmission and Causes of Prion Diseases
Prion Transmission and Propagation Modes
Metallic Poisoning
Viral Possibilities
Genetics
Sterilization
Prions in Yeast and Other Fungi
Prions - Proteins that Transmit the Mad Cow Disease
Introduction
Relationship between CJD and BSE
Mechanism of the Prion Diseases
Unsolved Puzzle
Effectiveness of Quinacrine for Treating Creutzfeldt-Jakob Disease
Analysis of Pentosan Polysulphate for Treating Prion Diseases
The Difficulty Posed by Blood Brain Barrier
Risks Associated with PPS
Efficacy Evaluation of Intraventricular PPS Administration
Species Barriers for Prions
TSE
Spreading of TSE
Efforts to Control TSE Related Diseases
Effect of TSE Related Diseases on Biopharmaceutical Industry
Development of In Vitro Diagnostics Polyclonals Free from Pathogen of Scrapie and BSE
Genotype
Extensive Monitoring of Disease Pathogens
Conclusion
Transmissible Spongiform Encephalopathy (TSE)
Exhibit 48. List of Prion Diseases and Pathogenesis in Humans
Exhibit 49. List of Prion Disease and Pathogenesis in Animals
Characteristics of TSE
Genetics
Epidemiology
Possible Cure or Vaccine
Research to Treat Prion Diseases
Bovine Spongiform Encephalopathy (BSE)
Source of the Epidemic
Cause
Cases of BSE
Measures to Prevent the Spread of BSE
Prion and BSE - Mad Cow Disease
Mechanism of Conversion of PrPC to PrPSc
Reported Cases of BSE
BSE Testing
The Detection of BSE in Rodents Increases the Need for Research
Regulations
BSE/TSEs Testing Regulations Imposed by European Union
Transmissible Mink Encephalopathy (TME)
TME Related Diseases
Clinical Characteristics of TME Infected Animals
Diagnosis
Prevalence of the Disease
Scrapie
History
Introduction
Epidemiology and Transmission
Clinical Signs
Wool Manufacturing Process - An Effective Route of BSE Propagation
Research
Diagnosis of Scrapie
Immunohistochemical (IHC) Detection
Capillary Electrophoresis Immunoassay
Eradication Program
Exhibit 50. Number of Scrapie Cases Reported in Great Britain (1993-2003)
Scrapie Cases Reported
Feline Spongiform Encephalopathy (FSE)
Chronic Wasting Disease (CWD)
Kuru
Gerstmann-Sträussler-Scheinker Syndrome (GSS)
Creutzfeldt - Jakob disease
CJD-Types and Characteristics
Sporadic CJD
Variant CJD
vCJD
Genetic CJD
Iatrogenic CJD
SpCJD
vCJD
iCJD
Familial CJD
Metallothionein
Laminin Receptor Protein / Laminin
Sporadic CJD
The EEG
Exhibit 51. Number of Reported Cases of vCJD by Country
Genetic CJD
Iatrogenic CJD
Exhibit 52. Referrals of Suspect CJD, Deaths of Definite and Probable CJD in the United Kingdom
CJD Control Measures in United Kingdom and United States
About Centers for Disease Control and Prevention
Fatal Familial Insomnia (FFI)
4.2 Technologies in Detection of Prions
Immunocapillary Electrophoresis (ICE)
Immunoblot (IB)
Histopathology and Immunohistochemistry
Protein-Based PCR for Prion Diseases
Synthetic Ligands
Postmortem Prion Disease Testing
Blood Testing for the Prion Disease Agent
Immuno-PCR
Bio Markers for Detection of Prions (Surrogate Markers)
Prion Infection
Surrogate Markers
Other Assays for Diagnosis of Prion Diseases
Prion Vaccines
4.3 Prion Deactivation Technologies
Prion Inactivation and Decontamination Techniques
Exhibit 53. Ineffective or Unreliable Methods of Eradicating Prions
4.3 Prion Reduction Filters
Evaluation of the Efficacy of Prion Reduction Filters
4.5 BSE Post Mortem Testing
Post Mortem BSE Testing
IDEXX HerdChek® Bovine Spongiform Encephalopathy Antigen Test Kit EIA
Post-Mortem Tests
Enfer TSE assay
Prionics®-Check WESTE
Prionics®-Check LIA
Prionics®-Check PrioSTRIP
Ante-Mortem Tests
Post Mortetm CWD Prion Diagnosis
Prions: Antigen-Capture Enzyme-Linked Immunoassay
Prion Diseases Management Policies
Health Control Policies in UK
European Union and BSE controls
Exhibit 54. Preventive Measures against the Introduction and Spread of BSE in the EU
Japan and BSE
Preface
FDA’s Qualitative Risk Assessment
Proteins from Cattle in Cosmetics
Modes for Transmission of Prions through Cosmetics
Identification of Hazard
Dose-Response Assessment
Characterization of Risk
Inferences
Prions: Animal Bioassays and Cell Culture Assays
Mechanism of Prion Formation
Animal Bioassays
Cell Culture Bioassays
Genetic Engineering Tools
Guidance on Minimizing the Risk of Transmitting Animal Spongiform Encephalopathies
via Human and Veterinary Medicinal Products
Regulatory Compliance
Risk Assessment
Legal Aspects
Clarification of Note for Guidance
Scope of the Note for Guidance
Relevant Animal Species
Materials
Seed Lots, Cell Banks and Routine Fermentation/Production
General Considerations
Scientific Principles for Minimising Risk
Source Animals
Geographical Sourcing
Bovine Materials
European Commission Scientific Steering Committee Classification
Sheep and Goats (Small Ruminants)
BSE Negligible Risk (Closed) Bovine Herds
Parts of Animal Bodies, Body Fluids and Secretions as Starting Materials
Age of Animals
Manufacturing Process
Cleaning Process
Validation
Risk Assessment of Materials or Substances Used in the Manufacture and Preparation of a Medicinal Product in the Context of Regulatory Compliance
Risk/Benefit Evaluation
Specific Considerations
Collagen
Gelatin
Bovine Blood Derivatives
Tallow Derivatives
Animal Charcoal
Milk and Milk Derivatives
Wool Derivatives
Amino Acids
Product Trends
A New Fluorescent Molecule Effective in Diagnosing Prion Disease
New Test to Detect Bovine Spongiform Encephalopathy
Hematech - Company Develops New BSE Resistant Cow
4.6 Prions – Research Briefs

5. CORPORATE DIRECTORY

6. PATENTS INFORMATION

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